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    Thieno [2,3-c] and [3,2-c] pyridines
    3.
    发明授权
    Thieno [2,3-c] and [3,2-c] pyridines 失效
    噻吩并[b 2,3-c {9 {0和{8,2-c {9 {

    公开(公告)号：US4104390A

    公开(公告)日：1978-08-01

    申请号：US808694

    申请日：1977-06-21

    Applicant: Gerard Ferrand ,  Daniel Frehel ,  Jean-Pierre Maffrand

    Inventor： Gerard Ferrand ,  Daniel Frehel ,  Jean-Pierre Maffrand

    IPC: A61K31/435 ,  A61K31/4365 ,  A61P7/02 ,  A61P29/00 ,  C07D333/20 ,  C07D333/36 ,  C07D495/04 ,  C07D513/04 ,  A61K31/38

    CPC classification number: C07D495/04 ,  C07D333/20

    Abstract: This invention relates to pyridine derivatives of the formulae: ##STR1## in which R.sup.1 is hydrogen, lower alkyl, aralkyl optionally substituted on the aromatic nucleus with at least a halogen atom or a hydroxy, nitro, amino, cyano, carboxy, alkoxycarbonyl, lower alkyl, lower alkoxy or trifluoromethyl group; R.sup.2 is hydrogen or lower alkyl; and R.sup.3 is hydrogen or at least a substituent selected from a halogen atom, a hydroxy, lower alkyl and lower alkoxy group, and their pharmaceutically acceptable inorganic or organic acid addition salts.Said compounds have particularly an anti-inflammatory and blood-platelet aggregation inhibiting activity.

    Abstract translation: 本发明涉及以下结构式的吡啶衍生物：其中R 1为氢，低级烷基，任选在芳核上被至少具有卤素原子取代的芳烷基或羟基，硝基，氨基，氰基，羧基，烷氧基羰基，低级 烷基，低级烷氧基或三氟甲基; R2是氢或低级烷基; 和R3是氢或至少一个选自卤素原子，羟基，低级烷基和低级烷氧基的取代基，以及它们的药学上可接受的无机酸或有机酸加成盐。

    4(3H)-pteridinones, preparation processes and drugs containing them
    7.
    发明授权
    4(3H)-pteridinones, preparation processes and drugs containing them 失效
    4（3H） - 哌啶酮，制备方法和含有它们的药物

    公开(公告)号：US5167949A

    公开(公告)日：1992-12-01

    申请号：US501104

    申请日：1990-03-29

    Applicant: Gerard Ferrand ,  Herve Dumas ,  Jean-Claude Depin ,  Yvette Quentin

    Inventor： Gerard Ferrand ,  Herve Dumas ,  Jean-Claude Depin ,  Yvette Quentin

    IPC: C07D239/48 ,  A61K31/495 ,  A61K31/505 ,  A61K31/519 ,  A61P11/08 ,  A61P37/08 ,  C07D475/02 ,  C07D475/06

    CPC classification number: C07D475/02

    Abstract: The present invention relates to 4(3H)-pteridinones represented by the formula: ##STR1## in which X is an oxygen atom or a sulphur atom, Y is a hydrogen atom, a lower alkyl radical, especially a methyl radical, at the 6-position or a hydroxyl group at the 7-position, R.sub.1 is a hydrogen atom, a lower alkyl radical, a substituted or unsubstituted phenyl radical, a benzyl radical, a methoxymethyl group, an acetyl group, a 2-acetoxyethyl group or a 2,2,2-trifluoroethyl group and R.sub.2 is a hydrogen atom or a lower alkyl radical, especially a methyl radical. Application of these compounds as anti-allergic drugs.

    Abstract translation: 本发明涉及由下式表示的4（3H） - 蝶啶酮：其中X是氧原子或硫原子，Y是氢原子，低级烷基，特别是甲基，在6 位置或羟基，R1是氢原子，低级烷基，取代或未取代的苯基，苄基，甲氧基甲基，乙酰基，2-乙酰氧基乙基或2 ，2,2-三氟乙基，R 2为氢原子或低级烷基，特别是甲基。 这些化合物作为抗过敏药物的应用。

    2-Amino-5-phenyl-1,3-benzodiazepines
    8.
    发明授权
    2-Amino-5-phenyl-1,3-benzodiazepines 失效
    2-氨基-5-苯基-1,3-苯并二氮杂卓

    公开(公告)号：US4554273A

    公开(公告)日：1985-11-19

    申请号：US578046

    申请日：1984-02-07

    Applicant: Michel Bayssat ,  Gerard Ferrand ,  Jean-Claude Depin

    Inventor： Michel Bayssat ,  Gerard Ferrand ,  Jean-Claude Depin

    IPC: A61K31/55 ,  A61P25/24 ,  A61P25/26 ,  C07D243/04 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D403/04

    CPC classification number: C07D401/12 ,  C07D243/04 ,  C07D403/12 ,  C07D405/12

    Abstract: Disclosed are 2-amino-5-phenyl-1,3-benzodiazepines of the formula ##STR1## wherein R.sub.1 and R.sub.2 are hydrogen, halogen, alkyl, or alkoxy; R.sub.2 being able to occupy any of the possible positions on the aromatic ring; R.sub.3 is hydrogen or alkyl; and R.sub.4 is hydrogen, alkyl, cycloalkyl, arylalkyl, heteroarylalkyl, dialkylaminoethyl, dialkylaminopropyl, (1-ethyl-2-pyrrolidino) methyl, dialkylamino, alkoxycarbonyl or cyano; or R.sub.3 and R.sub.4 form, with the adjacent nitrogen atom, a heterocycle having 5 to 7 side chains, optionally containing another heteroatom selected from oxygen, sulfur or nitrogen, this latter being able to be substituted by an alkyl group. The majority of the compounds are obtained by condensation of the corresponding 2-methylthio benzodiazepine hydroiodide with an appropriate amine. The compounds are useful as antidepressants.

    Abstract translation: 公开了下式的2-氨基-5-苯基-1,3-苯并二氮杂其中R 1和R 2是氢，卤素，烷基或烷氧基; R2能够占据芳香环上任何可能的位置; R3是氢或烷基; 并且R 4是氢，烷基，环烷基，芳基烷基，杂芳基烷基，二烷基氨基乙基，二烷基氨基丙基，（1-乙基-2-吡咯烷子基）甲基，二烷基氨基，烷氧基羰基或氰基; 或R3和R4与相邻的氮原子形成具有5至7个侧链的杂环，任选地含有选自氧，硫或氮的另外的杂原子，后者可被烷基取代。 大部分化合物通过相应的2-甲硫基苯并二氮杂环丁烷与合适的胺的缩合得到。 这些化合物可用作抗抑郁药。

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