发明授权
- 专利标题： Metabolic pathway engineering to increase production of ascorbic acid intermediates
- 专利标题（中）： 代谢途径工程增加抗坏血酸中间体的生产
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申请号： US229598申请日： 1988-08-08
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公开(公告)号： US5032514A公开(公告)日： 1991-07-16
- 发明人: Stephen Anderson , Robert A. Lazarus , Harvey I. Miller , R. Kevin Stafford
- 申请人： Stephen Anderson , Robert A. Lazarus , Harvey I. Miller , R. Kevin Stafford
- 申请人地址： CA San Francisco
- 专利权人： Genentech, Inc.
- 当前专利权人： Genentech, Inc.
- 当前专利权人地址： CA San Francisco
- 主分类号： C12N9/04
- IPC分类号： C12N9/04 ; C12P7/60
摘要：
In recombinant microorganisms which were rendered capable of converting 2,5-diketo-D-gluconic acid (2,5-DKG) to 2-keto-L-gulonic acid (2-KLG) by transfer of genetic material, the secondary metabolites and metabolic pathways leading to the metabolic diversion of 2-KLG and 2,5-DKG were determined, and the diversion of 2-KLG to L-iodonic acid (IA) or of 2,5-DKG to 5-keto-D-gluconate (5-KDH) was blocked.
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