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1.发明授权Metabolic pathway engineering to increase production of ascorbic acid intermediates 失效代谢途径工程增加抗坏血酸中间体的生产
公开(公告)号：US5032514A
公开(公告)日：1991-07-16
申请号：US229598
申请日：1988-08-08
CPC分类号： C12N9/0006 , C12P7/60
摘要： In recombinant microorganisms which were rendered capable of converting 2,5-diketo-D-gluconic acid (2,5-DKG) to 2-keto-L-gulonic acid (2-KLG) by transfer of genetic material, the secondary metabolites and metabolic pathways leading to the metabolic diversion of 2-KLG and 2,5-DKG were determined, and the diversion of 2-KLG to L-iodonic acid (IA) or of 2,5-DKG to 5-keto-D-gluconate (5-KDH) was blocked.
摘要翻译： 在通过遗传物质转移能够将2,5-二酮-D-葡糖酸（2,5-DKG）转化为2-酮-L-古洛糖酸（2-KLG）的重组微生物中，次级代谢物和 确定导致2-KLG和2,5-DKG代谢转移的代谢途径，并且将2-KLG转移到L-碘酸（IA）或2,5-DKG转化为5-酮-D-葡萄糖酸盐 （5-KDH）。
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公开(公告)号：US07256027B1
公开(公告)日：2007-08-14
申请号：US09332886
申请日：1999-06-15
CPC分类号： C12P7/60 , C12N9/0006
摘要： Mutants of 2,5-diketo-D-gluconic acid reductase A, an enzyme used to produce 2-keto-L-gulonic acid, a precursor of ascorbic acid (vitamin C) are prepared by site-directed mutagenesis. These mutants have increased catalytic activity, increased expression levels, and/or enhanced temperature stability.
摘要翻译： 通过定点诱变制备2,5-二酮-D-葡糖酸还原酶A的突变体，A是用于产生2-酮-L-古洛糖酸的酶，抗坏血酸（维生素C）的前体。 这些突变体具有增加的催化活性，增加的表达水平和/或增强的温度稳定性。
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公开(公告)号：US5583025A
公开(公告)日：1996-12-10
申请号：US249377
申请日：1994-05-24
IPC分类号： C12N15/09 , C12N1/21 , C12N9/04 , C12N15/53 , C12N15/74 , C12P7/60 , C12R1/01 , C12R1/02 , C12R1/18
CPC分类号： C12N9/0006 , C12N15/74 , C12P7/60
摘要： Mutants of 2,5-diketo-D-gluconic acid reductase A, an enzyme used to produce 2-keto-L-gulonic acid, a precursor of ascorbic acid (vitamin C) are prepared by site-directed mutagenesis. These mutants have increased catalytic activity, increased expression levels, and/or enhanced temperature stability.
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公开(公告)号：US5912161A
公开(公告)日：1999-06-15
申请号：US749337
申请日：1996-11-14
IPC分类号： C12N15/09 , C12N1/21 , C12N9/04 , C12N15/53 , C12N15/74 , C12P7/60 , C12R1/01 , C12R1/02 , C12R1/18 , C07H21/04
CPC分类号： C12N9/0006 , C12N15/74 , C12P7/60
摘要： Mutants of 2,5-diketo-D-gluconic acid reductase A, an enzyme used to produce 2-keto-L-gulonic acid, a precursor of ascorbic acid (vitamin C) are prepared by site-directed mutagenesis. These mutants have increased catalytic activity, increased expression levels, and/or enhanced temperature stability.
摘要翻译： 通过定点诱变制备2,5-二酮-D-葡糖酸还原酶A的突变体，A是用于产生2-酮-L-古洛糖酸的酶，抗坏血酸（维生素C）的前体。 这些突变体具有增加的催化活性，增加的表达水平和/或增强的温度稳定性。
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公开(公告)号：US5376544A
公开(公告)日：1994-12-27
申请号：US941414
申请日：1992-09-08
IPC分类号： C12N15/09 , C12N1/21 , C12N9/04 , C12N15/53 , C12N15/74 , C12P7/60 , C12R1/01 , C12R1/02 , C12R1/18
CPC分类号： C12N9/0006 , C12N15/74 , C12P7/60
摘要： Mutants of 2,5-diketo-D-gluconic acid reductase A, an enzyme used to produce 2-keto-L-gulonic acid, a precursor of ascorbic acid (vitamin C) are prepared by site-directed mutagenesis. These mutants have increased catalytic activity, increased expression levels, and/or enhanced temperature stability.
摘要翻译： 通过定点诱变制备2,5-二酮-D-葡糖酸还原酶A的突变体，A是用于产生2-酮-L-古洛糖酸的酶，抗坏血酸（维生素C）的前体。 这些突变体具有增加的催化活性，增加的表达水平和/或增强的温度稳定性。
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公开(公告)号：US09329017B2
公开(公告)日：2016-05-03
申请号：US14382636
申请日：2012-03-20
申请人： Michael Spomer , Stephen Anderson
发明人： Michael Spomer , Stephen Anderson
CPC分类号： G01B5/25 , G01B5/0007 , G01F1/8409 , G01F1/8413 , G01F1/8477 , G02B7/004
摘要： An alignment tool assembly (200) is provided. The alignment tool assembly (200) includes a base (201) and a mounting plate (202) coupled to the base (201). The alignment tool assembly (200) further includes one or more alignment blocks (204, 205, 205′) movable with respect to the mounting plate (202). One or more gauge apertures (250) are formed in the mounting plate (202) proximate an alignment block (204, 205, 205′) of the one or more alignment blocks (204, 205, 205′) sized and positioned to receive a portion of an alignment gauge (300).
摘要翻译： 提供了一种对准工具组件（200）。 对准工具组件（200）包括底座（201）和联接到基座（201）的安装板（202）。 对准工具组件（200）还包括可相对于安装板（202）移动的一个或多个对准块（204,205,205'）。 靠近所述一个或多个对准块（204,205,205'）的对准块（204,205,205'）形成在所述安装板（202）中的一个或多个标尺孔（250），所述对准块（204,205,205'）的尺寸和位置被接收 对准计量器（300）的一部分。
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公开(公告)号：US20120036880A1
公开(公告)日：2012-02-16
申请号：US12856213
申请日：2010-08-13
申请人： Stephen Anderson
发明人： Stephen Anderson
CPC分类号： F25D3/08 , F24F5/0017 , F24F2005/0067 , F24F2221/12 , Y02E60/147 , Y02E70/30
摘要： A portable air cooling system having a housing having an air inlet, an air outlet, an exterior surface and an interior cavity. A fan is axially disposed within the interior cavity for generating an air flow drawn from the air inlet, through the interior cavity and discharged through the air outlet. A photovoltaic panel is electrically coupled to the fan and provides sufficient electrical generating capacity to at least power the fan during daylight hours. A hydrating element is disposed intermediate the air inlet and air outlet for providing evaporative cooling. A cooling element is disposed intermediate the air inlet and air outlet and provides convective cooling by thermal transfer with a cold active cooling media such as water ice, dry ice or Gel Pack.
摘要翻译： 一种便携式空气冷却系统，具有具有空气入口，空气出口，外表面和内部空腔的壳体。 风扇轴向设置在内部空腔内，用于产生从空气入口抽出的空气流，穿过内部空腔并通过空气出口排出。 光伏面板电耦合到风扇并且提供足够的发电能力以在白天小时期间至少为风扇供电。 在空气入口和空气出口之间设置水合元件以提供蒸发冷却。 冷却元件设置在空气入口和空气出口之间，并通过热活性冷却介质（如水冰，干冰或凝胶组件）进行热传递提供对流冷却。
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公开(公告)号：US20100314485A1
公开(公告)日：2010-12-16
申请号：US12868582
申请日：2010-08-25
申请人： Stephen Anderson
发明人： Stephen Anderson
CPC分类号： A47K10/3818 , A47K2010/3206 , A47K2010/3246 , A47K2010/3266
摘要： According to one exemplary embodiment of the present invention, a center-pull bottom feed dispenser includes a housing defining a compartment and including a center-pull bottom feed arrangement for dispensing a sheet material that is in the form of a roll of the sheet material. The sheet material can be a pre-moistened airlaid web. The dispenser also includes a tray that supports the airlaid web roll and includes an outlet opening through which the airlaid web is fed to be accessible to a user. The tray includes a moisture retaining feature that directs fluid from the pre-moistened air-laid web away from the outlet opening and toward an outer peripheral edge of the roll.
摘要翻译： 根据本发明的一个示例性实施例，中心拉底部进料分配器包括限定隔室的壳体，并且包括用于分配片材材料卷的形式的片材的中心拉下底部进料装置。 片材可以是预湿润的成网织物。 分配器还包括支撑气流成网的卷筒纸的托盘，并且包括出口开口，送风卷筒纸通过该出口开口供用户使用。 托盘包括湿气保持特征，其将预先润湿的气流成网幅材的流体远离出口开口并朝向辊的外周边缘引导。
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公开(公告)号：US20080015582A1
公开(公告)日：2008-01-17
申请号：US11760569
申请日：2007-06-08
申请人： Gene DiPoto , Stephen Anderson
发明人： Gene DiPoto , Stephen Anderson
IPC分类号： A61F2/30
CPC分类号： A61B17/02 , A61B17/0218 , A61B17/0482 , A61B17/0483 , A61B17/06109 , A61B17/3421 , A61B17/3439 , A61B17/7002 , A61B17/7032 , A61B17/7035 , A61B17/708 , A61B17/7082 , A61B17/7083 , A61B17/7085 , A61B17/7091 , A61B17/8863 , A61B2017/0256 , A61B2017/3443
摘要： Systems, devices, and methods suitable for use with procedures performed at least partially percutaneously are provided. In some procedures, two or more access devices for providing access to adjacent surgical locations within a patient are used. Certain embodiments of the access device comprise an elongate body having a distal end with one or more cutouts. The cutouts on adjacent access devices are generally aligned with each other to permit passage of a portion of a fixation element from one access device to the other access device. A fastener with an elongated removable head may be delivered to the surgical site through the access device. After a distal end of the fastener is secured to the surgical site, a portion of the elongated housing is detached from the remainder of the fastener and removed from the patient.
摘要翻译： 提供了适用于至少部分经皮进行的程序的系统，装置和方法。 在一些程序中，使用用于提供对患者内的相邻手术位置的访问的两个或多个访问装置。 进入装置的某些实施例包括具有一个或多个切口的远端的细长主体。 相邻进入装置上的切口通常彼此对准，以允许固定元件的一部分从一个进入装置通过到另一个进入装置。 具有细长可拆卸头部的紧固件可以通过接入装置被输送到手术部位。 在紧固件的远端固定到手术部位之后，细长壳体的一部分与紧固件的其余部分分离并从患者身上移除。
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公开(公告)号：US20070290094A1
公开(公告)日：2007-12-20
申请号：US11746452
申请日：2007-05-09
申请人： Stephen Anderson
发明人： Stephen Anderson
IPC分类号： B65H16/02
CPC分类号： A47K10/3836 , A47K2010/3233 , A47K2010/3246 , A47K2010/3253
摘要： A tissue dispenser is provided by which a user may access one or more rolls of tissue. The dispenser generally includes a base and a cover. The dispenser includes at least one spindle, and preferably left and right spindles, with each spindle being supported by and extending from the base. The dispenser also has a plurality of sleeves interchangeably disposed on the shafts of the spindles. Each sleeve has an inner diameter dimensioned to receive a corresponding spindle, and an outer diameter. A plurality of fins is radially disposed on the outer diameter of the sleeve to circumferentially support the inner diameter of a core of a tissue roll. Different sleeves having different outer diameters to accommodate tissue rolls having different core sizes are provided. The dispenser may also include a door assembly configured to selectively cover a tissue roll on either the left or the right side of the base. A plurality of snap fittings configured to releasably attach to the door assembly may be provided. Each snap fitting has a different height to prevent the premature movement of the door assembly by the user from one side of the tissue dispenser to the other, depending upon the diameter of the core of the tissue rolls used.
摘要翻译： 提供了组织分配器，用户可以通过该分配器访问一个或多个组织卷。 分配器通常包括基座和盖子。 分配器包括至少一个主轴，优选的是左右主轴，每个主轴由底座支撑并从底座延伸。 分配器还具有可互换地设置在心轴的轴上的多个套筒。 每个套筒具有内径，其尺寸设计成可容纳相应的心轴和外径。 多个翅片径向设置在套筒的外径上以周向地支撑组织卷芯的内径。 提供具有不同外径的不同套筒以适应具有不同芯尺寸的组织辊。 分配器还可以包括构造为选择性地覆盖基部的左侧或右侧上的组织辊的门组件。 可以提供构造成可拆卸地附接到门组件的多个卡扣配件。 每个卡扣配件具有不同的高度，以防止使用者从组织分配器的一侧到另一侧的门组件的过早运动，这取决于所使用的组织辊的芯的直径。
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