发明授权
US5037984A 3-[4-(1-substituted-4-piperazinyl)butyl]-4-thiazolidinone compounds
失效
3- [4-(1-取代-4-哌嗪基)丁基] -4-噻唑烷酮化合物
- 专利标题: 3-[4-(1-substituted-4-piperazinyl)butyl]-4-thiazolidinone compounds
- 专利标题(中): 3- [4-(1-取代-4-哌嗪基)丁基] -4-噻唑烷酮化合物
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申请号: US487328申请日: 1990-03-02
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公开(公告)号: US5037984A公开(公告)日: 1991-08-06
- 发明人: Nicholas J. Hrib , John G. Jurcak
- 申请人: Nicholas J. Hrib , John G. Jurcak
- 申请人地址: NJ Somerville
- 专利权人: Hoechst-Roussel Pharmaceuticals Inc.
- 当前专利权人: Hoechst-Roussel Pharmaceuticals Inc.
- 当前专利权人地址: NJ Somerville
- 主分类号: A61K31/425
- IPC分类号: A61K31/425 ; A61K31/44 ; A61K31/47 ; A61K31/495 ; A61K31/505 ; A61P25/04 ; A61P25/08 ; A61P25/18 ; A61P25/20 ; A61P25/24 ; A61P25/26 ; C07D277/14 ; C07D277/60 ; C07D277/82 ; C07D417/12 ; C07D417/14 ; C07D513/10
摘要:
There are disclosed compounds of the formula ##STR1## where n is 0 or 1; A is ##STR2## where X in each occurrence is independently hydrogen, halogen, loweralkyl hydroxy, nitro, loweralkoxy, amino, cyano, trifluoromethyl or methylthio; Y in each occurrence is independently hydrogen, halogen, loweralkyl, hydroxy, nitro, loweralkoxy, amino, cyano, trifluoromethyl or methylthio; m is 1 or 2; k is 1 or 2; R.sub.1 and R.sub.2 are independently hydrogen, loweralkyl, ##STR3## or aryl except that when R.sub.1 is ##STR4## or aryl, R.sub.2 is hydrogen, or alternatively R.sub.1 +R.sub.2 taken together with the carbon atom to which they are attached form a cyclopentane, cyclohexane, cycloheptane, pyran, thiopyran, indan or piperidine ring; R.sub.3 and R.sub.4 are independently hydrogen or loweralkyl, or alternatively R.sub.3 +R.sub.4 taken together with the carbon atom to which they are attached form a cyclopentane, cyclohexane, cycloheptane, pyran, thiopyran, pyrrolidine or piperidine ring, the term aryl signifying an unsubstituted phenyl group or a phenyl group substituted with 1, 2 or 3 substituents each of which being independently loweralkyl, loweralkoxy, hydroxy, halogen, loweralkythio, cyano, amino or trifluoromethyl, which are useful as antipsychotic, analgesic, anticonvulsant and anxiolytic agents.