发明授权
US5066490A Protein crosslinking reagents cleavable within acidified intracellular
vesicles
失效
蛋白质交联试剂在酸化的细胞内可溶性蛋白
- 专利标题： Protein crosslinking reagents cleavable within acidified intracellular vesicles
- 专利标题（中）： 蛋白质交联试剂在酸化的细胞内可溶性蛋白
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申请号： US204163申请日： 1988-06-01
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公开(公告)号： US5066490A公开(公告)日： 1991-11-19
- 发明人: David M. Neville, Jr. , Kasturi Srinivasachar
- 申请人： David M. Neville, Jr. , Kasturi Srinivasachar
- 申请人地址： DC Washington
- 专利权人： The United States of America as represented by the Secretary of the Department of Health & Human Services
- 当前专利权人： The United States of America as represented by the Secretary of the Department of Health & Human Services
- 当前专利权人地址： DC Washington
- 主分类号： A61K31/70
- IPC分类号： A61K31/70 ; A61K31/785 ; A61K39/395 ; A61K45/00 ; A61K47/48 ; A61P31/12 ; C07D207/44 ; C07D207/452 ; C07D207/456 ; C07D493/10 ; C07K1/00 ; C07K14/00 ; C07K14/575 ; C07K14/62 ; C07K16/00
摘要：
Crosslinking reagents for amino group-containing compounds are provided, which crosslinkers can be cleaved under mildly acidic conditions. The crosslinkers can be used to crosslink biologically active substances to be delivered to the cells, wherein the crosslinker will be cleaved in the mildly acidic conditions within the cell.
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