The present invention provides a filler-containing thermoplastic resin composition which is well balanced in dimensinoal stability, rigidity, heat resistance and impact strength. This composition comprises: (I) 100 parts by weight of a resin comprising 5-95% by weight of a polyphenylene ether resin, a mixture of a polyphenylene ether resin and a styrene resin or a graft polymer of a polyphenylene ether resin and styrene and 95-5% by weight of polyamide resin, (II) 0-50 parts by weight of a rubber-like material, (III) 2.0-50 parts by weight of an inorganic filler having an average particle size of 5.0.mu. or less and/or a glass fiber and (IV) 0.01-10 parts by weight of at least one compatibilizing agent which improves compatibility between the polyphenylene resin and the polyamide resin. Talc is preferred as the inorganic filler.