发明授权
- 专利标题： Peptide and gene coding for same
- 专利标题（中）： 肽和基因编码相同
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申请号： US023818申请日： 1987-03-09
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公开(公告)号： US5118615A公开(公告)日： 1992-06-02
- 发明人: Hisayuki Matsuo , Kenji Kangawa , Yujiro Hayashi , Shinzo Oikawa , Takehiro Oshima , Shoji Tanaka , Hiroshi Nakazato , Yasunori Tawaragi
- 申请人： Hisayuki Matsuo , Kenji Kangawa , Yujiro Hayashi , Shinzo Oikawa , Takehiro Oshima , Shoji Tanaka , Hiroshi Nakazato , Yasunori Tawaragi
- 申请人地址： JPX Osaka
- 专利权人： Suntory Limited
- 当前专利权人： Suntory Limited
- 当前专利权人地址： JPX Osaka
- 优先权： JPX59-116605 19840608; JPX59-116606 19840608
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; C07K14/58 ; C12N15/12 ; C12N15/70
摘要：
Disclosed is a DNA fragment comprising a base sequence coding for a peptide occurring in human atrium cordis and having diuretic action or a precursor of the peptide, plasmids containing the DNA fragment, microorganisms transformed with the plasmid, and a process for production of the peptide using the transformant.Also disclosed is a new peptide consisting of 126 amino acids occurring in human atrium cordis and a precursor thereof. The peptide has notable diuretic action and hypotensive or antihypertensive actions.