发明授权
- 专利标题： Antisense oligonucleotides for inhibiting herpesviruses
- 专利标题（中）： 用于抑制HERPESVIRUSES的抗体寡核苷酸
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申请号： US485297申请日： 1990-02-26
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公开(公告)号： US5248670A公开(公告)日： 1993-09-28
- 发明人: Kenneth G. Draper , David J. Ecker , Christopher K. Mirabelli , Stanley T. Crooke
- 申请人： Kenneth G. Draper , David J. Ecker , Christopher K. Mirabelli , Stanley T. Crooke
- 申请人地址： CA Carlsbad
- 专利权人： ISIS Pharmaceuticals, Inc.
- 当前专利权人： ISIS Pharmaceuticals, Inc.
- 当前专利权人地址： CA Carlsbad
- 主分类号： A61K31/70
- IPC分类号： A61K31/70 ; A61K38/00 ; A61K48/00 ; A61P31/12 ; A61P31/22 ; C07H21/00 ; C07K14/03 ; C12N7/04 ; C12N15/09 ; C12N15/113 ; C12Q1/68
摘要：
Antisense oligonucleotides are disclosed having a length of 15-30 nucleotides containing the CAT sequence and hybridizable to herpes simplex virus type I gene UL13, UL39, or UL40. These antisense oligomers inhibit the replication of the virus at least three-fold. Pharmaceutical compositions containing these oligonucleotides as the active ingredients are also disclosed.
公开/授权文献
- US5669436A Method of continuously casting composite strip 公开/授权日：1997-09-23
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