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公开(公告)号：US6153595A
公开(公告)日：2000-11-28
申请号：US838715
申请日：1997-04-09
IPC分类号： C12N15/09 , A61K31/712 , A61K38/00 , A61K48/00 , A61P31/22 , C07H21/00 , C07H21/04 , C07K14/045 , C12N9/12 , C12N15/113 , C12Q1/70 , C12Q1/68
CPC分类号： C12N15/1133 , A61K31/70 , A61K31/711 , C07H21/00 , C07K14/005 , C12N9/1252 , C12Q1/705 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/334 , C12N2310/346 , C12N2310/3521 , C12N2310/3525 , C12N2710/16122
摘要： This invention concerns compositions and methods for the treatment of CMV infections. Antisense oligonucleotides are provided which are effective antiviral agents. In preferred embodiments, the oligonucleotides contain at least one 2'-methoxyethoxy modification and may be chimeric oligonucleotides.
摘要翻译： 本发明涉及用于治疗CMV感染的组合物和方法。 提供反义寡核苷酸是有效的抗病毒剂。 在优选实施方案中，寡核苷酸含有至少一个2'-甲氧基乙氧基修饰，并且可以是嵌合寡核苷酸。
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公开(公告)号：US06017756A
公开(公告)日：2000-01-25
申请号：US193627
申请日：1994-02-07
申请人： Kenneth G. Draper
发明人： Kenneth G. Draper
CPC分类号： C12N15/1131 , C12Q1/6876 , A61K38/00 , C12N2310/121
摘要： An enzymatic RNA molecule which specifically cleaves RNA of a hepatitis B virus.
摘要翻译： 一种特异性切割乙型肝炎病毒RNA的酶RNA分子。
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公开(公告)号：US5795778A
公开(公告)日：1998-08-18
申请号：US623891
申请日：1996-03-25
申请人： Kenneth G. Draper
发明人： Kenneth G. Draper
IPC分类号： C12N15/09 , A61K31/70 , A61K38/00 , A61K38/43 , A61K39/125 , A61K39/13 , A61K39/135 , A61K39/145 , A61K39/21 , A61K39/23 , A61K39/245 , A61K39/29 , A61K48/00 , A61P1/16 , A61P31/12 , A61P31/14 , A61P31/16 , A61P31/18 , A61P31/22 , A61P35/02 , C07H19/06 , C07H21/02 , C07K14/08 , C12N5/10 , C12N7/00 , C12N9/00 , C12N9/22 , C12N15/10 , C12N15/113 , C12N15/85 , C12N15/86 , C12Q1/68 , C12Q1/70 , C12R1/91 , C12R1/93 , G01N33/569 , C07H19/10
CPC分类号： C12N15/86 , C07H19/06 , C07K14/005 , C12N15/1003 , C12N15/113 , C12N15/1131 , C12N15/85 , C12Q1/706 , A61K38/00 , C12N2310/111 , C12N2310/12 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3521 , C12N2310/3531 , C12N2310/3533 , C12N2310/3535 , C12N2310/53 , C12N2710/16622 , C12N2740/14043
摘要： An enzymatic RNA molecule which specifically cleaves a herpes simplex virus mRNA molecule.
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4.发明授权Method and reagent for treatment of diseases caused by expression of the bcl-2 gene 失效用于治疗由bcl-2基因表达引起的疾病的方法和试剂
公开(公告)号：US5750390A
公开(公告)日：1998-05-12
申请号：US936421
申请日：1992-08-26
IPC分类号： C12N15/113 , C12N15/10
CPC分类号： C12N15/113 , C12N15/1135 , C12N15/1138 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/124 , C12N2310/126
摘要： An enzymatic RNA molecule which cleaves bcl.2 mRNA associated with development or maintenance of follicular lymphoma.
摘要翻译： 裂解与发育或维持滤泡淋巴瘤相关的bcl.2 mRNA的酶促RNA分子。
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公开(公告)号：US5616490A
公开(公告)日：1997-04-01
申请号：US434503
申请日：1995-05-04
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C12N9/64 , C12N15/10 , C12N15/113 , C07H21/04 , C12N15/85
CPC分类号： C12N15/113 , C07K14/4702 , C12N15/101 , C12N15/1131 , C12N15/1135 , C12N15/1136 , C12N15/1137 , C12N15/1138 , C12N9/6491 , A61K38/00 , A61K48/00 , C12N2310/111 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/1241 , C12N2310/126 , C12N2310/127 , C12N2310/32 , C12N2310/322 , C12N2310/333 , C12N2310/334 , C12N2310/335 , C12N2310/336 , C12N2310/3513 , C12N2310/3523 , C12N2310/3527 , C12N2310/3533 , C12N2310/3535
摘要： An enzymatic RNA molecule which cleaves mRNA associated with development or maintenance of an inflammatory disease.
摘要翻译： 切割与发炎或维持炎性疾病相关的mRNA的酶RNA分子。
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公开(公告)号：US5612215A
公开(公告)日：1997-03-18
申请号：US390850
申请日：1995-02-17
IPC分类号： A61K38/00 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07K14/47 , C12N9/64 , C12N15/113 , C12N15/85 , A61K48/00 , C12Q1/68
CPC分类号： C12N15/113 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07K14/4702 , C12N15/1135 , C12N15/1136 , C12N15/1137 , C12N15/1138 , C12N9/6491 , C12Y304/24017 , A61K38/00 , C12N2310/111 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/126 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/332 , C12N2310/346
摘要： An enzymatic RNA molecule which cleaves mRNA associated with development or maintenance of an arthritic condition.
摘要翻译： 一种酶切RNA分子，其切割与发育或维持关节炎病症相关的mRNA。
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公开(公告)号：US5610054A
公开(公告)日：1997-03-11
申请号：US182968
申请日：1994-01-13
申请人： Kenneth G. Draper
发明人： Kenneth G. Draper
IPC分类号： C12N15/09 , A61K35/12 , A61K38/00 , A61K39/29 , A61K48/00 , A61P1/16 , A61P31/12 , C07H21/02 , C07K14/08 , C12N5/10 , C12N7/00 , C12N9/00 , C12N15/113 , C12N15/51 , C12N15/85 , C12N15/86 , C12Q1/70 , C12Q1/68
CPC分类号： C12N15/1131 , C07K14/005 , C12N15/85 , C12N15/86 , C12Q1/701 , C12Q1/707 , A61K38/00 , C12N2310/111 , C12N2310/12 , C12N2310/121 , C12N2310/122 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3521 , C12N2310/3531 , C12N2310/3533 , C12N2310/3535 , C12N2770/24222 , C12N2770/24243
摘要： An enzymatic RNA molecule which specifically cleaves RNA of a hepatitis C virus.
摘要翻译： 一种特异性切割丙型肝炎病毒RNA的酶RNA分子。
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8.发明授权Method and reagent for treatment of lung cancer and other malignancies caused by the deregulation of L-MYC gene expression 失效用于治疗由L-MYC基因表达失调引起的肺癌和其他恶性肿瘤的方法和试剂公开(公告)号：US06492512B1
公开(公告)日：2002-12-10
申请号：US07936532
申请日：1992-08-26
IPC分类号： C07H2102
CPC分类号： C12N15/113 , C12N15/1135 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/124 , C12N2310/126
摘要： An enzymatic RNA molecule which cleaves mRNA associated with development or maintenance of lung cancer.
摘要翻译： 切割与肺癌发展或维持相关的mRNA的酶RNA分子。
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公开(公告)号：US06440719B1
公开(公告)日：2002-08-27
申请号：US09634262
申请日：2000-08-08
申请人： Kenneth G. Draper
发明人： Kenneth G. Draper
IPC分类号： C12N704
CPC分类号： C12N15/113 , A61K38/00 , C07K14/005 , C12N15/85 , C12N15/86 , C12N2310/12 , C12N2310/121 , C12N2310/122 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3521 , C12N2310/3531 , C12N2310/3533 , C12N2310/3535 , C12N2710/16622 , C12Q1/701 , C12Q1/705
摘要： An enzymatic RNA molecule which specifically cleaves a herpes simplex virus mRNA molecule.
摘要翻译： 一种特异性切割单纯疱疹病毒mRNA分子的酶RNA分子
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10.发明授权Ribozyme treatment of diseases or conditions related to levels of NF-&kgr;B 失效与NF-κB水平相关的疾病或病症的核酶治疗公开(公告)号：US06410224B1
公开(公告)日：2002-06-25
申请号：US08777916
申请日：1996-12-23
IPC分类号： C07H2104
CPC分类号： C12N15/101 , A61K38/00 , A61K48/00 , C07K14/4702 , C12N9/6491 , C12N15/113 , C12N15/1131 , C12N15/1135 , C12N15/1136 , C12N15/1137 , C12N15/1138 , C12N2310/111 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/1241 , C12N2310/126 , C12N2310/127 , C12N2310/315 , C12N2310/317 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/332 , C12N2310/333 , C12N2310/334 , C12N2310/335 , C12N2310/336 , C12N2310/3513 , C12N2310/3517 , C12N2310/3523 , C12N2310/3527 , C12N2310/3533 , C12N2310/3535 , C12N2310/3521
摘要： Enzymatic RNA molecules which cleave rel A mRNA.
摘要翻译： 分解相关A mRNA的酶RNA分子
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