发明授权
US5252732A D-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and
O-alkynylheteroarylmacrolides having immunosuppressive activity
失效
具有免疫抑制活性的D-杂芳基，O-烷基杂芳基，O-烯基杂芳基和O-炔基杂芳基大环内酯
- 专利标题： D-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides having immunosuppressive activity
- 专利标题（中）： 具有免疫抑制活性的D-杂芳基，O-烷基杂芳基，O-烯基杂芳基和O-炔基杂芳基大环内酯
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申请号： US921851申请日： 1992-08-05
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公开(公告)号： US5252732A公开(公告)日： 1993-10-12
- 发明人: Peter J. Sinclair , Joung Goulet , Frederick Wong , Mark Goulet , William H. Parsons , Matthew J. Wyvratt
- 申请人： Peter J. Sinclair , Joung Goulet , Frederick Wong , Mark Goulet , William H. Parsons , Matthew J. Wyvratt
- 申请人地址： NJ Rahway
- 专利权人： Merck & Co., Inc.
- 当前专利权人： Merck & Co., Inc.
- 当前专利权人地址： NJ Rahway
- 主分类号： A61K31/40
- IPC分类号： A61K31/40 ; A61K31/445 ; A61K31/495 ; A61K31/70 ; A61P37/06 ; C07D498/18 ; C07H19/01 ; A61K31/395 ; C07D491/16
摘要：
O-Heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides of the general structural Formula I: ##STR1## have been prepared from suitable precursors by alkylation and/or arylation at C-3" and/or C-4" of the cyclohexyl ring. These macrolide immunosuppressants are useful in a mammalian host for the treatment of autoimmune diseases, infectious diseases, the prevention of rejection of foreign organ transplants and/or related afflictions, diseases and illnesses.
公开/授权文献
- US4747139A Software security method and systems 公开/授权日：1988-05-24
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