发明授权
US5260447A Polyhydroxycyclopentane derivatives, their preparation and their
therapeutic use
失效
多羟基环戊烷衍生物，其制备及其治疗用途
- 专利标题： Polyhydroxycyclopentane derivatives, their preparation and their therapeutic use
- 专利标题（中）： 多羟基环戊烷衍生物，其制备及其治疗用途
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申请号： US835185申请日： 1992-02-13
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公开(公告)号： US5260447A公开(公告)日： 1993-11-09
- 发明人: Mutsuo Nakajima , Osamu Ando , Kiyoshi Hamano , Shuji Takahashi , Takeshi Kinoshita , Hideyuki Haruyama , Akira Sato , Yasuyuki Takamatsu , Ryuzo Enokita
- 申请人： Mutsuo Nakajima , Osamu Ando , Kiyoshi Hamano , Shuji Takahashi , Takeshi Kinoshita , Hideyuki Haruyama , Akira Sato , Yasuyuki Takamatsu , Ryuzo Enokita
- 申请人地址： JPX Tokyo
- 专利权人： Sankyo Company, Limited
- 当前专利权人： Sankyo Company, Limited
- 当前专利权人地址： JPX Tokyo
- 主分类号： C07C215/42
- IPC分类号： C07C215/42 ; A61K20060101 ; A61K31/13 ; C07C20060101 ; C07C215/44 ; C07D263/52 ; C07D413/12 ; C12P7/38 ; C12P17/14 ; C07D261/20 ; C07C211/00
摘要：
5-Amino-1-(hydroxymethyl)cyclopentane-1,2,3,4-tetraol and 2-amino-4-(hydroxymethyl)-3a,5,6,6a-tetrahydro-4H-cyclopent[d]oxazole-4,5,6-triol, which have the ability to inhibit the activity of sugar hydrolases, especially .beta.-glucosidase and sucrase and can thus be used for the treatment and prophylaxis of tumorous conditions, AIDS, diabetes and obesity, can be prepared by hydrolysis of trehazolin. 2-Amino-4-(hydroxymethyl)-3a,5,6,6a-tetrahydro-4H-cyclopent[d]oxazole-4,5,6-triol can also be prepared by fermentation using newly isolated strains Micromonospora sp. SANK 62390, FERM BP-3521 and Amycolatopsis sp. SANK 60791, FERM BP-3513.
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