公开(公告)号：US07939081B2

公开(公告)日：2011-05-10

申请号：US11997112

申请日：2006-08-08

Applicant: Tsuyoshi Hosoya ,  Jun Ohsumi ,  Kiyoshi Hamano ,  Yasunori Ono ,  Masami Miura

Inventor： Tsuyoshi Hosoya ,  Jun Ohsumi ,  Kiyoshi Hamano ,  Yasunori Ono ,  Masami Miura

IPC: A61K36/84 ,  C12P21/04 ,  A01N63/04

CPC classification number: C07D307/91 ,  C12P17/04 ,  C12R1/645

Abstract: The present invention provides a process for producing cercosporamide comprising culturing a fungus belonging to the genus Lachnum and/or fungus belonging to the genus Pseudaegerita and recovering cercosporamide from the culture thereof. In addition, the present invention provides cercosporamide acquired according to this production process. Further, the present invention provides novel microorganisms consisting of Lachnum fuscescens SANK 19096, Lachnum calycioides SANK 12497, Lachnum caesaliatum SANK 10906, and Pseudaegerita websteri SANK 11006.

Abstract translation: 本发明提供了一种生产铈孢子酰胺的方法，其包括培养属于属于假单胞菌属的Lachnum属和/或真菌的真菌并从其培养物中回收孢子虫酰胺。 此外，本发明提供根据该制造方法获得的孢霉素。 此外，本发明提供了由Lachnum fuscescens SANK 19096，Lachnum calycioides SANK 12497，Lachnum caesaliatum SANK 10906和Pseudaegerita websterica SANK 11006组成的新型微生物。

公开(公告)号：US5827855A

公开(公告)日：1998-10-27

申请号：US579840

申请日：1995-12-28

Applicant: Hiroshi Kogen ,  Sadao Ishihara ,  Teiichiro Koga ,  Eiichi Kitazawa ,  Nobufusa Serizawa ,  Kiyoshi Hamano

Inventor： Hiroshi Kogen ,  Sadao Ishihara ,  Teiichiro Koga ,  Eiichi Kitazawa ,  Nobufusa Serizawa ,  Kiyoshi Hamano

IPC: A61K31/22 ,  A61K31/35 ,  A61K31/365 ,  A61K31/366 ,  A61P3/06 ,  C07C69/03 ,  C07C69/24 ,  C07C69/33 ,  C07C69/67 ,  C07C69/675 ,  C07C69/732 ,  C07C69/734 ,  C07D309/30 ,  C12N9/02 ,  C12P7/62 ,  C12P17/06 ,  C12R1/01 ,  C12R1/465 ,  C12R1/785 ,  A01N43/42 ,  C07C67/74

CPC classification number: C07C69/33 ,  C07C69/675 ,  C07C69/732 ,  C07D309/30 ,  C12N9/0093 ,  C12P17/06 ,  C12P7/62 ,  Y02P20/55

Abstract: Compounds of formula (I): ##STR1## wherein R.sup.1 represents a group of formula (II) or (III): ##STR2## R.sup.2 is alkyl, alkenyl or alkynyl; R.sup.3 and R.sup.4 are each hydrogen, alkyl, alkenyl or alkynyl; R.sup.5 is hydrogen or a carboxy-protecting group; R.sup.a is a group of formula --OR.sup.6 ; R.sup.6 is hydrogen; R.sup.6a and R.sup.6b are each hydrogen, a hydroxy-protecting group, alkyl, alkanesulfonyl, halogenated alkanesulfonyl or arysulfonyl, and their salts and esters. Such compounds inhibit the synthesis of cholesterol, and can be used for the treatment and prophylaxis of hypercholesterolemia and of various cardiac disorders.

Abstract translation: （I）的化合物：其中R 1表示式（II）或（III）的基团：其中R 2是烷基，烯基或炔基; R3和R4各自为氢，烷基，烯基或炔基; R5是氢或羧基保护基; Ra是式-OR6的一组; R6是氢; R6a和R6b各自为氢，羟基保护基，烷基，烷磺酰基，卤代烷磺酰基或芳磺酰基，以及它们的盐和酯。 这些化合物抑制胆固醇的合成，并可用于治疗和预防高胆固醇血症和各种心脏疾病。

公开(公告)号：US4438277A

公开(公告)日：1984-03-20

申请号：US368673

申请日：1982-04-15

Applicant: Akira Terahara ,  Kiyoshi Hamano ,  Yoshio Tsujita ,  Minoru Tanaka

Inventor： Akira Terahara ,  Kiyoshi Hamano ,  Yoshio Tsujita ,  Minoru Tanaka

IPC: C07C69/013 ,  A61K31/19 ,  A61K31/215 ,  A61K31/365 ,  A61K31/366 ,  A61P3/06 ,  C07C51/00 ,  C07C59/11 ,  C07C59/13 ,  C07C59/215 ,  C07C59/46 ,  C07C59/62 ,  C07C59/76 ,  C07C59/84 ,  C07C59/90 ,  C07C67/00 ,  C07C69/18 ,  C07C69/21 ,  C07C69/30 ,  C07C69/33 ,  C07C69/67 ,  C07C69/675 ,  C07C69/716 ,  C07C69/73 ,  C07C69/732 ,  C07C69/738 ,  C07C407/00 ,  C07C409/14 ,  C07D309/30 ,  C07C69/03 ,  C07C69/734

CPC classification number: C07D309/30 ,  C07C59/11 ,  C07C59/46 ,  C07C59/76 ,  C07C59/84

Abstract: Compounds of formula (I): ##STR1## (in which: Z represents a group of formula ##STR2## A represents a group of formula ##STR3## B represents a group of formula ##STR4## R.sup.1 represents a hydrogen atom or a methyl group; R.sup.2, R.sup.3, R.sup.4 and R.sup.6 are the same or different and each represents a hydrogen atom or an acyl group;R.sup.5 represents a carboxy group;R.sup.7 represents a hydrogen atom, an alkyl group or an acyl group;X represents a halogen atom; andthe bond represents a double bond)and salts and esters of the carboxy group represented by R.sup.5 have useful anti-hypercholesteraemic activity and may be prepared from certain natural products obtainable by cultivation of microorganisms of the genera Penicillium or Monascus.

Abstract translation: 式（I）的化合物：其中：Z表示式的基团A表示式的基团：B表示式的基团R 1表示氢原子或 甲基; R2，R3，R4和R6相同或不同，各自表示氢原子或酰基; R5表示羧基; R7表示氢原子，烷基或酰基; X表示 卤素原子;键表示双键），由R5表示的羧基的盐和酯具有有效的抗高胆固醇血症活性，并且可以由通过培养青霉属或红曲霉属的微生物获得的某些天然产物制备。

公开(公告)号：US5839567A

公开(公告)日：1998-11-24

申请号：US584319

申请日：1996-01-16

Applicant: Hisashi Kyotani ,  Takashi Okamura ,  Kiyoshi Hamano

Inventor： Hisashi Kyotani ,  Takashi Okamura ,  Kiyoshi Hamano

IPC: B61B10/02 ,  B61B13/12 ,  B62D65/18 ,  B65G35/06 ,  B65G17/32

CPC classification number: B61B13/127 ,  B61B10/025 ,  B62D65/18 ,  B65G35/06

Abstract: The present invention relates to a conveying system such as in an assembly line, more particularly to a plurality of transport cars without motor that are driven in close contact with each other on an endless path on guide rails having curved sections, and a friction feeder for moving the transport cars. The cars have a main body and a support for objects to be conveyed. The main body has a plurality of movable bodies and means for coupling the movable bodies to allow a relative yielding motion between the movable bodies at the curved sections in the conveying paths. Driven faces are formed on the movable bodies parallel to the running direction, and a feeder along the conveying path and having a motor driven feed roller that acts on the driven faces of the movable bodies.

Abstract translation: 本发明涉及一种诸如装配线的输送系统，更具体地说，涉及在具有弯曲部分的导轨上的循环路径上彼此紧密接触的多个无马达的运输车辆，以及用于 移动运输车。 汽车具有主体和支撑物体被输送。 主体具有多个可移动体和用于联接可移动体以允许可移动体在输送路径中的弯曲部分处的相对屈服运动的装置。 驱动面形成在平行于运行方向的可移动体上，沿着传送路径形成有进给器，并且具有作用在可移动体的从动面上的马达驱动进给辊。

公开(公告)号：US5272174A

公开(公告)日：1993-12-21

申请号：US919154

申请日：1992-07-23

Applicant: Kouhei Furuya ,  Takao Okazaki ,  Yoshio Tsujita ,  Seigo Iwado ,  Kiyoshi Hamano ,  Masao Kuroda ,  Jun Yoshikawa ,  Toshiaki Iwai ,  Kunio Nakano

Inventor： Kouhei Furuya ,  Takao Okazaki ,  Yoshio Tsujita ,  Seigo Iwado ,  Kiyoshi Hamano ,  Masao Kuroda ,  Jun Yoshikawa ,  Toshiaki Iwai ,  Kunio Nakano

IPC: C07D309/10 ,  C12P7/62 ,  C12P17/06 ,  A61K31/365 ,  A61K31/215

CPC classification number: C12R1/645 ,  C07D309/10 ,  C12P17/06 ,  C12P7/62 ,  C12R1/365 ,  Y10S514/824

Abstract: Derivatives of ML-236B carboxylic acid, its salts and esters and corresponding lactone have a hydroxy group at the 3"-position and optionally also at the 6'-position. These derivatives may be prepared by the enzymatic hydroxylation of a corresponding ML-236B compound employing an enzyme produced by a microorganism of the genus Streptomyces or Amycolata, especially Streptomyces sp. SANK 62285, Streptomyces sp. SANK 62385, Streptomyces sp. SANK 62485, Streptomyces sp. SANK 62585, Amycolata autotrophica SANK 62781. Amycolata autotrophica subsp. canberrica SANK 62882 or Amycolata autotrophica subsp. amethystina SANK 62981. These derivatives have the ability to inhibit cholesterol biosynthesis.

Abstract translation: ML-236B羧酸的衍生物，其盐和酯和相应的内酯在3“位和任选也在6'位具有羟基。 这些衍生物可以通过使用由链霉菌属或Amycolata属的微生物，特别是链霉菌属（Streptomyces sp。）产生的酶的相应的ML-236B化合物的酶促羟基化来制备。 SANK 62285，Streptomyces sp。 SANK 62385，Streptomyces sp。 SANK 62485，Streptomyces sp。 SANK 62585，Amycolata autotrophica SANK 62781. Amycolata autotrophica subsp。 canberrica SANK 62882或Amycolata autotrophica subsp。 紫杉醇SANK 62981.这些衍生物具有抑制胆固醇生物合成的能力。

公开(公告)号：US5451688A

公开(公告)日：1995-09-19

申请号：US174661

申请日：1993-12-28

Applicant: Hiroshi Kogen ,  Sadao Ishihara ,  Teiichiro Koga ,  Eiichi Kitazawa ,  Nobufusa Serizawa ,  Kiyoshi Hamano

Inventor： Hiroshi Kogen ,  Sadao Ishihara ,  Teiichiro Koga ,  Eiichi Kitazawa ,  Nobufusa Serizawa ,  Kiyoshi Hamano

IPC: A61K31/22 ,  A61K31/35 ,  A61K31/365 ,  A61K31/366 ,  A61P3/06 ,  C07C69/03 ,  C07C69/24 ,  C07C69/33 ,  C07C69/67 ,  C07C69/675 ,  C07C69/732 ,  C07C69/734 ,  C07D309/30 ,  C12N9/02 ,  C12P7/62 ,  C12P17/06 ,  C12R1/01 ,  C12R1/465 ,  C12R1/785 ,  C07C69/74

CPC classification number: C07C69/33 ,  C07C69/675 ,  C07C69/732 ,  C07D309/30 ,  C12N9/0093 ,  C12P17/06 ,  C12P7/62 ,  Y02P20/55

Abstract: Compounds of formula (I): ##STR1## [wherein R.sup.1 represents a group of formula (II) or (III): ##STR2## R.sup.2 is alkyl, alkenyl or alkynyl; R.sup.3 and R.sup.4 are each hydrogen, alkyl, alkenyl or alkynyl; R.sup.5 is hydrogen or a carboxy-protecting group; R.sup.a is hydrogen or a group of formula and --OR.sup.6 ; R.sup.6, R.sup.6a and R.sup.6b are each hydrogen, a hydroxy-protecting group, alkyl, alkanesulfonyl, halogenated alkanesulfonyl or arylsulfonyl] and their salts and esters have the ability to inhibit the synthesis of cholesterol, and can thus be used for the treatment and prophylaxis of hypercholesterolemia and of various cardiac disorders.

Abstract translation: 式（I）化合物：其中R 1表示式（II）或（III）的基团：烯基或炔基; R3和R4各自为氢，烷基，烯基或炔基; R5是氢或羧基保护基; R a是氢或式-OR 6基团; R6，R6a和R6b各自为氢，羟基保护基，烷基，烷基磺酰基，卤代烷磺酰基或芳基磺酰基），其盐和酯具有抑制胆固醇合成的能力，因此可用于治疗和预防 高胆固醇血症和各种心脏疾病。

公开(公告)号：US4361515A

公开(公告)日：1982-11-30

申请号：US256243

申请日：1981-04-21

Applicant: Akira Terahara ,  Kiyoshi Hamano ,  Yoshio Tsujita ,  Minoru Tanaka

Inventor： Akira Terahara ,  Kiyoshi Hamano ,  Yoshio Tsujita ,  Minoru Tanaka

IPC: C07C69/013 ,  A61K31/19 ,  A61K31/215 ,  A61K31/365 ,  A61K31/366 ,  A61P3/06 ,  C07C51/00 ,  C07C59/11 ,  C07C59/13 ,  C07C59/215 ,  C07C59/46 ,  C07C59/62 ,  C07C59/76 ,  C07C59/84 ,  C07C59/90 ,  C07C67/00 ,  C07C69/18 ,  C07C69/21 ,  C07C69/30 ,  C07C69/33 ,  C07C69/67 ,  C07C69/675 ,  C07C69/716 ,  C07C69/73 ,  C07C69/732 ,  C07C69/738 ,  C07C407/00 ,  C07C409/14 ,  C07D309/30

CPC classification number: C07D309/30 ,  C07C59/11 ,  C07C59/46 ,  C07C59/76 ,  C07C59/84

Abstract: Compounds of formula (I): ##STR1## (in which: Z represents a group of formula ##STR2## A represents a group of formula ##STR3## B represents a group of formula ##STR4## R.sup.1 represents a hydrogen atom or a methyl group; R.sup.2, R.sup.3, R.sup.4 and R.sup.6 are the same or different and each represents a hydrogen atom or an acyl group;R.sup.5 represents a carboxy group;R.sup.7 represents a hydrogen atom, an alkyl group or an acyl group;X represents a halogen atom; andthe bond represents a double bond)and salts and esters of the carboxy group represented by R.sup.5 and compounds of formula (II): ##STR5## (in which R.sup.1, is as defined above and R.sup.2 represents an .alpha.-methylbutyryl group; and R.sup.4 represents a hydrogen atom) have useful anti-hypercholesteraemic activity and may be prepared from certain natural products obtainable by cultivation of microorganisms of the genera Penicillium or Monascus.

Abstract translation: 式（I）的化合物：其中：Z表示式的基团A表示式的基团：B表示式的基团R 1表示氢原子或 甲基; R2，R3，R4和R6相同或不同，各自表示氢原子或酰基; R5表示羧基; R7表示氢原子，烷基或酰基; X表示 卤素原子;键表示双键）和由R5表示的羧基和式（II）化合物的盐和酯：其中R 1如上所定义，R 2表示α - 甲基丁酰基; R4表示氢原子）具有有效的抗高胆固醇血症活性，并且可以通过培养青霉属或红曲霉属的微生物获得的某些天然产物制备。

公开(公告)号：US5153124A

公开(公告)日：1992-10-06

申请号：US393001

申请日：1989-08-11

Applicant: Kouhei Furuya ,  Takao Okazaki ,  Yoshio Tsujita ,  Seigo Iwado ,  Kiyoshi Hamano ,  Masao Kuroda ,  Jun Yoshikawa ,  Toshiaki Iwai ,  Kunio Nakano

Inventor： Kouhei Furuya ,  Takao Okazaki ,  Yoshio Tsujita ,  Seigo Iwado ,  Kiyoshi Hamano ,  Masao Kuroda ,  Jun Yoshikawa ,  Toshiaki Iwai ,  Kunio Nakano

IPC: A61K31/225 ,  C07C67/31 ,  C07C69/675 ,  C07D309/10 ,  C07D309/30 ,  C12P7/62 ,  C12P17/06

CPC classification number: C12R1/645 ,  C07D309/10 ,  C12P17/06 ,  C12P7/62 ,  C12R1/365

Abstract: Derivatives of ML-236B carboxylic acid, its salts and esters and corresponding lactone have a hydroxy group at the 3"-position and optionally also at the 6'-position. These derivatives may be prepared by the enzymatic hydroxylation of a corresponding ML-236B compound employing an enzyme produced by a microorganism of the genus Streptomyces or Amycolata, especially Streptomyces sp. SANK 62285, Streptomyces sp. SANK 62385, Streptomyces sp. SANK 62485, Streptomyces sp. SANK 62585, Amycolata autotrophica SANK 62781, Amycolata autotrophica subsp. canberrica SANK 62882 or Amycolata autotrophica subsp. amethystina SANK 62981. These derivatives have the ability to inhibit cholesterol biosynthesis.

Abstract translation: ML-236B羧酸的衍生物，其盐和酯和相应的内酯在3“位和任选也在6'位具有羟基。 这些衍生物可以通过使用由链霉菌属或Amycolata属的微生物，特别是链霉菌属（Streptomyces sp。）产生的酶的相应的ML-236B化合物的酶促羟基化来制备。 SANK 62285，Streptomyces sp。 SANK 62385，Streptomyces sp。 SANK 62485，Streptomyces sp。 SANK 62585，Amycolata autotrophica SANK 62781，Amycolata autotrophica subsp。 canberrica SANK 62882或Amycolata autotrophica subsp。 紫杉醇SANK 62981.这些衍生物具有抑制胆固醇生物合成的能力。

公开(公告)号：US20100152467A1

公开(公告)日：2010-06-17

申请号：US11997112

申请日：2006-08-08

Applicant: Tsuyoshi Hosoya ,  Jun Ohsumi ,  Kiyoshi Hamano ,  Yasunori Ono ,  Masami Miura

Inventor： Tsuyoshi Hosoya ,  Jun Ohsumi ,  Kiyoshi Hamano ,  Yasunori Ono ,  Masami Miura

IPC: C07D307/77 ,  C12P17/04 ,  C12N1/14

CPC classification number: C07D307/91 ,  C12P17/04 ,  C12R1/645

Abstract: The present invention provides a process for producing cercosporamide comprising culturing a fungus belonging to the genus Lachnum and/or fungus belonging to the genus Pseudaegerita and recovering cercosporamide from the culture thereof. In addition, the present invention provides cercosporamide acquired according to this production process. Further, the present invention provides novel microorganisms consisting of Lachnum fuscescens SANK 19096, Lachnum calycioides SANK 12497, Lachnum caesaliatum SANK 10906, and Pseudaegerita websteri SANK 11006.

Abstract translation: 本发明提供了一种生产铈孢子酰胺的方法，其包括培养属于属于假单胞菌属的Lachnum属和/或真菌的真菌并从其培养物中回收孢子虫酰胺。 此外，本发明提供根据该制造方法获得的孢霉素。 此外，本发明提供了由Lachnum fuscescens SANK 19096，Lachnum calycioides SANK 12497，Lachnum caesaliatum SANK 10906和Pseudaegerita websterica SANK 11006组成的新型微生物。

公开(公告)号：US5260447A

公开(公告)日：1993-11-09

申请号：US835185

申请日：1992-02-13

Applicant: Mutsuo Nakajima ,  Osamu Ando ,  Kiyoshi Hamano ,  Shuji Takahashi ,  Takeshi Kinoshita ,  Hideyuki Haruyama ,  Akira Sato ,  Yasuyuki Takamatsu ,  Ryuzo Enokita

Inventor： Mutsuo Nakajima ,  Osamu Ando ,  Kiyoshi Hamano ,  Shuji Takahashi ,  Takeshi Kinoshita ,  Hideyuki Haruyama ,  Akira Sato ,  Yasuyuki Takamatsu ,  Ryuzo Enokita

IPC: C07C215/42 ,  A61K20060101 ,  A61K31/13 ,  C07C20060101 ,  C07C215/44 ,  C07D263/52 ,  C07D413/12 ,  C12P7/38 ,  C12P17/14 ,  C07D261/20 ,  C07C211/00

CPC classification number: C07D263/52 ,  C07C215/44 ,  C07D413/10 ,  C12P17/14 ,  C07C2101/06

Abstract: 5-Amino-1-(hydroxymethyl)cyclopentane-1,2,3,4-tetraol and 2-amino-4-(hydroxymethyl)-3a,5,6,6a-tetrahydro-4H-cyclopent[d]oxazole-4,5,6-triol, which have the ability to inhibit the activity of sugar hydrolases, especially .beta.-glucosidase and sucrase and can thus be used for the treatment and prophylaxis of tumorous conditions, AIDS, diabetes and obesity, can be prepared by hydrolysis of trehazolin. 2-Amino-4-(hydroxymethyl)-3a,5,6,6a-tetrahydro-4H-cyclopent[d]oxazole-4,5,6-triol can also be prepared by fermentation using newly isolated strains Micromonospora sp. SANK 62390, FERM BP-3521 and Amycolatopsis sp. SANK 60791, FERM BP-3513.

Abstract translation: 5-氨基-1-（羟甲基）环戊烷-1,2,3,4-四醇和2-氨基-4-（羟甲基）-3a，5,6,6a-四氢-4H-环戊二烯并[d]恶唑-4 具有抑制糖水解酶，特别是β-葡糖苷酶和蔗糖酶的活性，因此可用于治疗和预防肿瘤病症，AIDS，糖尿病和肥胖症的能力的5,6-三醇可以通过水解制备 的trehazolin。 2-氨基-4-（羟甲基）-3a，5,6,6a-四氢-4H-环戊[d]恶唑-4,5,6-三醇也可以通过使用新分离的小单孢菌属 SANK 62390，FERM BP-3521和Amycolatopsis sp。 SANK 60791，FERM BP-3513。