公开(公告)号：US20090233952A1

公开(公告)日：2009-09-17

申请号：US12066813

申请日：2006-09-13

申请人： Tomio Kimura ,  Nobuyuki Ohkawa ,  Takayoshi Nagasaki ,  Atsuhiro Sugidachi ,  Osamu Ando

发明人： Tomio Kimura ,  Nobuyuki Ohkawa ,  Takayoshi Nagasaki ,  Atsuhiro Sugidachi ,  Osamu Ando

IPC分类号： A61K31/443 ,  C07D317/72 ,  A61K31/357 ,  C07D405/08 ,  A61K31/4025 ,  C07D319/04 ,  C07D405/10

CPC分类号： C07C311/14 ,  C07C2601/16 ,  C07C2602/50 ,  C07D303/38 ,  C07D307/94 ,  C07D317/72 ,  C07D319/08 ,  C07D321/10 ,  C07D327/04 ,  C07D339/06 ,  C07D339/08 ,  C07D493/04 ,  C07D493/10

摘要： [Object] To provide a substituted cycloalkene derivative having an action to suppress intracellular signal transduction or cell activation induced by endotoxin and to suppress cell responses due to the intracellular signal transduction and cell activation such as an excess generation of inflammatory mediators such as TNF-α, pharmacologically acceptable salts therefor, a medicament containing them as an active ingredient, a preparation method therefor, and a medicament containing the aforementioned substituted cycloalkene derivative as an active ingredient which is superior in prophylaxis and/or treatment of diseases such as sepsis (septic shock, disseminated intravascular coagulation, multiple organ failure and the like), that are associated with intracellular signal transduction or cell activation induced by endotoxin and to cell responses to the intracellular signal transduction and cell activation.[Solution] A compound represented by the general formula (I): {whereinX and Y represent a group in which X and Y together with a carbon atom to which they are bound form ring A (the ring is 3- to 7-membered heterocyclyl ring or 3- to 7-membered cycloalkyl ring), each represents a hydrogen atom, or X and Y together represent a substituent of ring B. l and m, independently from each other, represent an integer of 0 to 3, and l+m is 1 to 3. R1 is an aliphatic hydrocarbon group and the like which may be substituted with a group selected from Substituent group β and Substituent group γ. n represents an integer of 0 to 3. R2 is a C1-C6 alkyl group and the like which may be substituted with a group selected from a hydrogen atom and Substituent group β. R3 is a phenyl group, 5- to 6-membered heteroaryl group and the like which may be substituted with a group selected from Substituent group ε. R5 is a C1-C6 alkyl group and the like which may be substituted with a group selected from a hydrogen atom and Substituent group β. Provided that in the case where R3 is a phenyl group which may be substituted with a group selected from Substituent group ε, X and Y represent a group in which X and Y together with a carbon atom to which they are bound form ring A, or X and Y together represent a substituent of ring B.

公开(公告)号：US20090151146A1

公开(公告)日：2009-06-18

申请号：US12192439

申请日：2008-08-15

申请人： Kousuke Nagai ,  Osamu Ando ,  Kouhei Jiuchi

发明人： Kousuke Nagai ,  Osamu Ando ,  Kouhei Jiuchi

IPC分类号： B23P11/00 ,  B21D39/03

CPC分类号： B21D39/032 ,  B21K25/00 ,  F16B5/045 ,  Y10T29/49938 ,  Y10T29/53996

摘要： A method for joining a holed member, including a through-hole, and an unholed member together, the method includes deforming the unholed member against the through-hole of the holed member so that a flat portion of the holed member around the through-hole is deformed into the shape of a truncated conical projection and so that the unholed member is deformed along the truncated conical projection to partly project from the through-hole, and deforming a portion of the unholed member which projects from the through-hole to come into intimate contact with a wall surface of the through-hole of the holed member.

摘要翻译： 一种用于将包括通孔和不合缝构件的孔构件接合在一起的方法包括使不通孔构件抵靠孔构件的通孔变形，使得孔构件在通孔周围的平坦部分 变形为截头圆锥形突起的形状，使得未开孔的构件沿着截头圆锥形突起变形，以从通孔部分地突出，并使从通孔突出的未凹陷构件的一部分变形 与孔洞构件的通孔的壁面紧密接触。

公开(公告)号：US20070117773A1

公开(公告)日：2007-05-24

申请号：US11604630

申请日：2006-11-27

申请人： Makoto Koizumi ,  Osamu Ando

发明人： Makoto Koizumi ,  Osamu Ando

IPC分类号： A61K48/00 ,  C07H21/04

CPC分类号： C12N15/1137 ,  A61K31/7125 ,  C07H21/00 ,  C12N2310/11 ,  C12N2310/3231 ,  C12Y207/07049

摘要： A telomerase-inhibiting ENA oligonucleotide compound represented by a formula: E1-B1-B2-B3-B4-E2 (I), wherein E1 represents a group represented by the formula R1-; E2 represents a group represented by the formula -B7-R2; B4, B5, and B8 are identical or different, and each represents Tp; B1, B2, B3, and B12 are identical or different, and each represents Gp; B16 represents Cp; and B6, B10, B14, and B18 are identical or different, and each represents Ap, or a pharmacologically acceptable salt thereof for treating diseases in which telomerase is involved, such as cancer.

摘要翻译： 1.一种由式E1-B1-B2-B3-B4-E2（Ⅰ）表示的端粒酶抑制型ENA寡核苷酸化合物，其中，E1表示式R1-表示的基团。 E2表示由式-B7-R2表示的基团; B4，B5和B8是相同或不同的，并且各自表示T

P; B1，B2，B3和B12相同或不同，并且各自表示G < B16表示C p 和B6，B10，B14和B18相同或不同，并且各自表示用于治疗涉及端粒酶的疾病例如癌症的Aβ或其药理学上可接受的盐。

公开(公告)号：US20060155074A1

公开(公告)日：2006-07-13

申请号：US10530096

申请日：2003-10-03

申请人： Masashi Kudo ,  Kenichi Fujimoto ,  Atsushi Koga ,  Yoshifumi Kojima ,  Osamu Ando ,  Yoshiki Nakagawa

发明人： Masashi Kudo ,  Kenichi Fujimoto ,  Atsushi Koga ,  Yoshifumi Kojima ,  Osamu Ando ,  Yoshiki Nakagawa

IPC分类号： C09K3/10 ,  F16J15/10 ,  F02F7/00 ,  F02F11/00

CPC分类号： F16J15/102 ,  C08F220/18 ,  C08G77/12 ,  C08L33/14 ,  C08L57/04 ,  C08L83/04 ,  C09J133/08 ,  C09K3/10 ,  C09K2200/0208 ,  C09K2200/0625 ,  F01M2011/0091 ,  F16J15/14 ,  C08L2666/04 ,  C08F2220/285 ,  C08F236/02

摘要： A sealing material, which comprises a curing product of a composition comprising (A) an acrylic polymer having at least one alkenyl group capable of undergoing hydrosilylation reaction, (B) a hydrosilyl group-containing compound and (C) a hydrosilylation catalyst as essential components, is suitable for use as cam cover seals and oil pan seals for automobile engines, fuel cell cooling medium seals, automobile wire harnesses seals, HDD cover gasket or vibration-insulating HDD cover gasket seals, etc.

公开(公告)号：US5307155A

公开(公告)日：1994-04-26

申请号：US830364

申请日：1992-01-31

申请人： Osamu Ando ,  Katsumi Harada

发明人： Osamu Ando ,  Katsumi Harada

IPC分类号： G01J3/02 ,  G01N21/01 ,  G01N21/27 ,  G01N21/59 ,  G01N21/86

CPC分类号： G01N21/01 ,  G01N21/59 ,  G01N21/86

摘要： A spectro photometer deflects a measuring beam off its original axis to pass through a long sample, and returns the measuring beam to its final direction after passing through the sample. The sample is guided along a path which is clear of a reference beam of the spectro photometer. This arrangement permits double-beam measurement of long samples, with good signal-to-noise ratio. Deflection is accomplished using a plurality of mirrors.

摘要翻译： 光谱光度计将测量光束偏离其原始轴线，以通过长样品，并在通过样品后将测量光束返回到其最终方向。 样品沿着远离光谱光度计的参考光束的路径被引导。 这种布置允许长样品的双光束测量，具有良好的信噪比。 使用多个反射镜实现偏转。

公开(公告)号：USD329614S

公开(公告)日：1992-09-22

申请号：US571893

申请日：1990-08-24

申请人： Osamu Ando ,  Susumu Ogiwara

设计人： Osamu Ando ,  Susumu Ogiwara

公开(公告)号：US5019949A

公开(公告)日：1991-05-28

申请号：US493688

申请日：1990-03-15

申请人： Hironosuke Ikeda ,  Nobuhiro Furukawa ,  Koji Nishio ,  Masahisa Fujimoto ,  Hitoshi Ono ,  Osamu Ando

发明人： Hironosuke Ikeda ,  Nobuhiro Furukawa ,  Koji Nishio ,  Masahisa Fujimoto ,  Hitoshi Ono ,  Osamu Ando

IPC分类号： H01G9/00 ,  H01G9/02 ,  H01G9/025

CPC分类号： H01G9/0032 ,  H01G11/48 ,  H01G11/56 ,  H01G9/025 ,  Y02E60/13 ,  Y10T29/417

摘要： A solid electrolytic capacitor is disclosed wherein use is made of an electrode produced by simultaneously forming an oxide film layer and a conductive polymer layer through electrolytic oxidation or other chemical treatments on a metal subjected to a surface roughening treatment, or forming a conductive polymer layer through plasma polymerization or other chemical treatments on a metal successively subjected to surface roughening and anodic oxidation treatments.

公开(公告)号：US4668092A

公开(公告)日：1987-05-26

申请号：US801825

申请日：1985-11-26

申请人： Osamu Ando

发明人： Osamu Ando

IPC分类号： G01J3/06 ,  G01J3/18

CPC分类号： G01J3/06

摘要： A wavelength driving device for use in monochromators which comprises an optical element for dispersing light into different wavelengths, means for supporting the optical element for rotation about a first axis, a stepping motor, a first toothed pulley of a relatively small diameter connected to the output shaft of the stepping motor for simultaneous stepwise rotation therewith, a first gear of a relatively large diameter fixed to the supporting means for simultaneous rotation about the first axis, a second gear of a relatively small diameter mounted for rotation about a second axis and meshing with the first gear, a second toothed pulley of a relatively large diameter fixed to the second gear for simultaneous rotation about the second axis, a toothed belt connecting the first and second toothed pulleys, and circuit means for controlling the rotation of the stepping motor.

摘要翻译： 一种用于单色器的波长驱动装置，包括用于将光分散到不同波长的光学元件，用于支撑围绕第一轴旋转的光学元件的装置，步进电机，连接到输出端的相对小直径的第一齿形皮带轮 所述步进电机的轴与所述步进电动机同时逐步旋转，固定到所述支撑装置上以相对于所述第一轴线同时旋转的相对较大直径的第一齿轮，相对小直径的第二齿轮，其安装成绕第二轴线旋转并与 第一齿轮，固定到第二齿轮上的相对较大直径的第二齿形皮带轮，用于围绕第二轴线同时旋转，连接第一和第二齿形皮带轮的齿形带以及用于控制步进电动机旋转的电路装置。

公开(公告)号：USRE43858E1

公开(公告)日：2012-12-11

申请号：US13224745

申请日：2006-09-13

申请人： Tomio Kimura ,  Nobuyuki Ohkawa ,  Takayoshi Nagasaki ,  Atsuhiro Sugidachi ,  Osamu Ando

发明人： Tomio Kimura ,  Nobuyuki Ohkawa ,  Takayoshi Nagasaki ,  Atsuhiro Sugidachi ,  Osamu Ando

IPC分类号： A61K31/335 ,  C07D317/72

摘要： A compound of formula (I) Wherein X, Y, ring A, ring B, l, m, R1, R2, R4 and R5 are as defined herein, to supress intracellular signal transduction or cell activation induced by endotoxin and to suppress cell responses due to the intracellular signal transduction and cell activation such as an excess generation of inflammatory mediators such as TNF-α, pharmacologically acceptable salts therefor, a preparation method therefor, and a medicament containing the aforementioned substituted cycloalkene derivative as an active ingredient which is superior in prophylaxis and/or treatment of diseases such as sepsis (septic shock, disseminated intravascular coagulation, multiple organ failure and the like), that are associated with intracellular signal transduction or cell activation induced by endotoxin and to cell responses to the intracellular signal transduction and cell activation.

摘要翻译： 式（I）化合物其中X，Y，环A，环B，l，m，R 1，R 2，R 4和R 5如本文所定义，以抑制由内毒素诱导的细胞内信号转导或细胞活化并抑制细胞反应 由于细胞内信号转导和细胞活化，例如过量产生炎症介质如TNF-α，其药理学上可接受的盐，其制备方法，以及含有上述取代的环烯烃衍生物作为活性成分的药物，其优于 与细胞内信号转导或由内毒素诱导的细胞活化以及对细胞内信号转导和细胞的细胞反应相关的诸如败血症（败血症休克，弥散性血管内凝血，多器官功能衰竭等）的疾病的预防和/或治疗 激活。

公开(公告)号：US5290649A

公开(公告)日：1994-03-01

申请号：US246916

申请日：1988-09-16

申请人： Tetsumi Suzuki ,  Hitoshi Ono ,  Osamu Ando

发明人： Tetsumi Suzuki ,  Hitoshi Ono ,  Osamu Ando

IPC分类号： C09B26/02 ,  G03G5/06

CPC分类号： C09B26/02 ,  G03G5/0668

摘要： An electrophotographic photoreceptor is formed by a photosensitive layer containing a naphtylhydrazone compound of the formula: ##STR1## wherein X and Y are independently a hydrogen atom, lower alkyl group, lower alkoxy group, phenoxy group or arylalkoxy group; R.sup.1 is a naphtyl group; R.sup.2 is a hydrogen atom, lower alkyl group, allyl group, substituted or unsubstituted phenyl group, or aralkyl group; and l and m are 1 or 2. The photoreceptor thus formed is not only highly sensitive but resistant to ozone deterioration, which markedly improves the durability thereof.

摘要翻译： 电子照相感光体由含有下式的化合物（*化学结构*）的感光层形成，其中X和Y独立地为氢原子，低级烷基，低级烷氧基，苯氧基或芳基烷氧基; R1是萘基; R2是氢原子，低级烷基，烯丙基，取代或未取代的苯基或芳烷基; l和m为1或2.由此形成的感光体不仅高度敏感，而且耐臭氧劣化，这显着提高了其耐久性。