- 专利标题: Biodegradable in-situ forming implants and methods of producing the same
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申请号: US788159申请日: 1991-12-23
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公开(公告)号: US5278202A公开(公告)日: 1994-01-11
- 发明人: Richard L. Dunn , James P. English , Donald R. Cowsar , David D. Vanderbilt
- 申请人: Richard L. Dunn , James P. English , Donald R. Cowsar , David D. Vanderbilt
- 申请人地址: CO Fort Collins
- 专利权人: Atrix Laboratories, Inc.
- 当前专利权人: Atrix Laboratories, Inc.
- 当前专利权人地址: CO Fort Collins
- 主分类号: A61L27/00
- IPC分类号: A61L27/00 ; A61F2/00 ; A61F2/02 ; A61F2/30 ; A61K9/00 ; A61K9/22 ; A61K47/34 ; A61L15/44 ; A61L15/62 ; A61L24/00 ; A61L24/04 ; A61L24/06 ; A61L26/00 ; A61L27/16 ; A61L27/18 ; A61L27/26 ; A61L27/34 ; A61L27/50 ; A61L27/54 ; A61L27/58 ; C08L67/00 ; C08L69/00 ; C08L77/00
摘要:
A biodegradable polymer is provided for use in providing syringeable, in-situ forming, solid biodegradable implants for animals. The polymer is placed into the animal in liquid form and cures to form the implant in-situ. A thermoplastic system to form said implant comprises the steps of dissolving a non-reactive polymer in biocompatible solvent to form a liquid, placing the liquid within the animal, and allowing the solvent to dissipate to produce the implant. An alternative, thermosetting system comprises mixing together effective amounts of a liquid acrylic ester terminated, biodegradable prepolymer and a curing agent, placing the liquid mixture within an animal and allowing the prepolymer to cure to form the implant. Both systems provide a syringeable, solid biodegradable delivery system by the addition of an effective level of biologically active agent to the liquid before injection into the body.
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