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    Process and delivery container for lyophilizing active agent
    2.
    发明申请
    Process and delivery container for lyophilizing active agent 有权
    用于冻干活性剂的加工和输送容器

    公开(公告)号：US20010042317A1

    公开(公告)日：2001-11-22

    申请号：US09909671

    申请日：2001-07-20

    申请人： Atrix Laboratories, Inc.

    发明人： Cody L. Yarborough ,  Dominic Gregory Madril ,  Rajan Bawa

    IPC分类号： F26B005/06 ,  B01L003/14

    CPC分类号： F26B5/06 ,  A61M5/178

    摘要： A process for lyophilizing a solution of an active agent in a delivery container is provided. Solution of active agent is deposited into a delivery container, the container is covered with a covering plate and placed inside a lyophilizing apparatus. Lyophilization is conducted to dryness by radiation, convection or both. Also provided is a device made by this process, an active agent-plastic administration device such as a syringe containing an active agent in the form of lyophilized cake, and an array of such administration devices.

    摘要翻译： 提供了一种用于将活性剂溶液冻干在递送容器中的方法。 将活性剂的溶液沉积到输送容器中，将容器用覆盖板覆盖并置于冻干装置内。 通过辐射，对流或两者将冻干干燥。 还提供了通过该方法制造的装置，活性剂 - 塑料给药装置，例如含有冻干饼形式的活性剂的注射器，以及这种给药装置的阵列。

    Polymer formulation for prevention of surgical adhesions
    4.
    发明授权
    Polymer formulation for prevention of surgical adhesions 失效
    用于预防手术粘连的聚合物制剂

    公开(公告)号：US5962006A

    公开(公告)日：1999-10-05

    申请号：US877391

    申请日：1997-06-17

    申请人： Jeffrey L. Southard ,  Richard L. Dunn

    发明人： Jeffrey L. Southard ,  Richard L. Dunn

    IPC分类号： A61L31/06 ,  A61K9/08 ,  A61K47/22 ,  A61K47/34

    CPC分类号： A61L31/06

    摘要： The invention is directed to a polymer formulation in which a pharmaceutically acceptable, biocompatible, biodegradable and/or bioerodible, water-coagulable thermoplastic polymer or copolymer which is substantially insoluble in an aqueous medium is dissolved in .epsilon.-caprolactone, a pharmaceutically-acceptable, moderately water-soluble organic solvent. When brought in contact with an aqueous environment, such as body or tissue fluids, the .epsilon.-caprolactone slowly dissipates into the aqueous fluid. As the .epsilon.-caprolactone dissipates, the water-insoluble thermoplastic polymer coagulates to form a flexible matrix. Preferably, the thermoplastic polymer is a copolymer of caprolactone or methylene carbonate and lactide or glycolide monomers. More preferably, the thermoplastic polymer is poly(DL-lactide-co-caprolactone). The polymer formulation may also contain a biologically active agent and/or a rate modifying agents to control the rate of release of the biologically active agent. The invention is also directed to a method of making the pliable matrix and the pliable matrix itself.

    摘要翻译： 本发明涉及聚合物制剂，其中基本上不溶于水性介质的药学上可接受的，生物相容的，可生物降解的和/或可生物腐蚀的可水凝的热塑性聚合物或共聚物溶解在ε-己内酯中，其药学上可接受的，适度的 水溶性有机溶剂。 当与诸如身体或组织液体的水性环境接触时，ε-己内酯缓慢地散入到含水流体中。 当ε-己内酯消散时，水不溶性热塑性聚合物凝结形成柔性基质。 优选地，热塑性聚合物是己内酯或碳酸亚甲酯与丙交酯或乙交酯单体的共聚物。 更优选地，热塑性聚合物是聚（DL-丙交酯 - 共 - 己内酯）。 聚合物制剂还可含有生物活性剂和/或速率调节剂以控制生物活性剂的释放速率。 本发明还涉及一种制造柔韧性基质和柔韧性基体本身的方法。

    METHOD FOR LYOPHILIZING AN ACTIVE AGENT
    9.
    发明申请
    METHOD FOR LYOPHILIZING AN ACTIVE AGENT 有权
    用于将活性剂代谢的方法

    公开(公告)号：US20080244923A1

    公开(公告)日：2008-10-09

    申请号：US12140519

    申请日：2008-06-17

    申请人： Cody L. Yarborough ,  Dominic G. Madril ,  Rajan Bawa

    发明人： Cody L. Yarborough ,  Dominic G. Madril ,  Rajan Bawa

    IPC分类号： F26B5/06

    CPC分类号： A61J1/1412 ,  A61M5/002 ,  A61M5/008 ,  A61M5/178 ,  A61M5/1782 ,  A61M5/31 ,  A61M2202/06 ,  F26B5/06 ,  Y10T436/25 ,  Y10T436/25375

    摘要： A process for lyophilizing a solution of an active agent in a container is provided. Solution of active agent is deposited into a container, the container is covered with a covering plate and placed inside a lyophilizing apparatus. Lyophilization can be conducted to dryness by radiation, convection or both. Also provided is a device made by this process, an active agent-plastic administration device (e.g., a syringe), containing an active agent in the form of lyophilized cake, and an array of such administration devices.

    摘要翻译： 提供了将活性剂溶液冻结在容器中的方法。 将活性剂溶液沉积在容器中，将容器用覆盖板覆盖并置于冻干装置内。 可以通过辐射，对流或两者将冻干物质干燥。 还提供了通过该方法制造的装置，包含冻干饼形式的活性剂的活性剂 - 塑料给药装置（例如注射器）和这种给药装置的阵列。

    Biodegradable polymer composition
    10.
    发明申请
    Biodegradable polymer composition 有权
    可生物降解的聚合物组成

    公开(公告)号：US20020090398A1

    公开(公告)日：2002-07-11

    申请号：US10047483

    申请日：2002-01-14

    申请人： Atrix Laboratories, Inc.

    发明人： Richard L. Dunn ,  James P. English

    IPC分类号： A61K009/14

    CPC分类号： A61K9/0024

    摘要： A flowable composition containing a biocompatible, biodegradable, branched thermoplastic polymer is used to form solid matrices such as implants and controlled-release, drug-compositions in a body. The flowable composition with or without bioactive agent can be administered by syringe and needle to form in situ a solid matrix. Alternatively, the flowable composition can be used to form ex vivo solid biodegradable matrices such as articles, implants and devices. The articles implants and the like can then used as solid fasteners, prosthetic devices, and controlled drug compositions.

    摘要翻译： 使用包含生物相容性，可生物降解的支化热塑性聚合物的可流动组合物在体内形成固体基质，例如植入物和控制释放的药物组合物。 具有或不具有生物活性剂的可流动组合物可以通过注射器和针头施用以形成固体基质。 或者，可流动组合物可用于形成离体固体生物可降解基质，例如制品，植入物和装置。 然后，物品植入物等可用作固体紧固件，假体装置和受控药物组合物。