发明授权
US5328470A Treatment of diseases by site-specific instillation of cells or
site-specific transformation of cells and kits therefor
失效
通过细胞的位点特异性滴注或细胞的位点特异性转化及其试剂盒来治疗疾病
- 专利标题： Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor
- 专利标题（中）： 通过细胞的位点特异性滴注或细胞的位点特异性转化及其试剂盒来治疗疾病
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申请号： US741244申请日： 1991-07-26
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公开(公告)号： US5328470A公开(公告)日： 1994-07-12
- 发明人: Elizabeth G. Nabel , Gary J. Nabel
- 申请人： Elizabeth G. Nabel , Gary J. Nabel
- 申请人地址： MI Ann Arbor
- 专利权人： The Regents of the University of Michigan
- 当前专利权人： The Regents of the University of Michigan
- 当前专利权人地址： MI Ann Arbor
- 主分类号： A61K31/70
- IPC分类号： A61K31/70 ; A61B17/22 ; A61K9/00 ; A61K9/08 ; A61K31/715 ; A61K35/14 ; A61K35/76 ; A61K38/00 ; A61K38/22 ; A61K38/27 ; A61K38/46 ; A61K39/00 ; A61K47/42 ; A61K47/48 ; A61K48/00 ; A61L29/16 ; A61M25/00 ; A61P3/08 ; A61P3/10 ; A61P7/02 ; A61P9/00 ; A61P9/10 ; A61P31/12 ; A61P31/18 ; A61P35/00 ; C12M1/00 ; C12N5/10 ; C12N15/09 ; C12R1/91 ; A61M29/00
摘要：
A method for the direct treatment towards the specific sites of a disease is disclosed. This method is based on the delivery of proteins by catheterization to discrete blood vessel segments using genetically modified or normal cells or other vector systems. Endothelial cells expressing recombinant therapeutic agent or diagnostic proteins are situated on the walls of the blood vessel or in the tissue perfused by the vessel in a patient. This technique, provides for the transfer of cells or vectors and expression of recombinant genes in vivo and allows the introduction of proteins of therapeutic or diagnostic value for the treatment of diseases.
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