发明授权
- 专利标题： Targeting of therapeutic agents using polysaccharides
- 专利标题（中）： 使用多糖靶向治疗剂
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申请号： US936873申请日： 1992-08-27
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公开(公告)号： US5336506A公开(公告)日： 1994-08-09
- 发明人: Lee Josephson , Ernest V. Groman , Chu Jung , Jerome M. Lewis
- 申请人： Lee Josephson , Ernest V. Groman , Chu Jung , Jerome M. Lewis
- 申请人地址： MA Cambridge
- 专利权人： Advanced Magnetics Inc.
- 当前专利权人： Advanced Magnetics Inc.
- 当前专利权人地址： MA Cambridge
- 主分类号： A61K47/48
- IPC分类号： A61K47/48 ; A61K49/04 ; A61K49/18 ; C08G18/18 ; C08G18/20 ; C08G18/24 ; C08G18/26 ; C08J9/14 ; G01R33/28 ; A01K31/715
摘要：
The invention relates to a method for the targeting of a therapeutic agent to a specific population of cells, wherein a complex is formed between the therapeutic agent and a polysaccharide capable of interacting with a cell receptor, and wherein the resulting complex is internalized into the cell by receptor mediated endocytosis (RME). In one embodiment of the invention, a complex of a therapeutic agent containing iron and the polysaccharide arabinogalactan may be formed and used to deliver iron specifically to hepatocytes by RME.
公开/授权文献
- US5953809A Method of joining glass run channels to brackets 公开/授权日：1999-09-21
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