公开(公告)号：US5554386A

公开(公告)日：1996-09-10

申请号：US260551

申请日：1994-06-16

申请人： Ernest V. Groman ,  Edward T. Menz ,  Philip M. Enriquez ,  Chu Jung ,  Jerome M. Lewis ,  Lee Josephson

发明人： Ernest V. Groman ,  Edward T. Menz ,  Philip M. Enriquez ,  Chu Jung ,  Jerome M. Lewis ,  Lee Josephson

IPC分类号： A61K47/48 ,  A61K49/04 ,  A61K49/18 ,  C08G18/18 ,  C08G18/20 ,  C08G18/24 ,  C08G18/26 ,  C08J9/14 ,  G01R33/28 ,  A61K47/26 ,  A61K31/495 ,  A61K31/56 ,  A61K31/70 ,  A61K33/26 ,  A61K38/21 ,  A61K39/395

CPC分类号： A61K47/488 ,  A61K47/4823 ,  A61K47/48861 ,  A61K49/0442 ,  B82Y5/00 ,  C08G18/1808 ,  C08G18/1816 ,  C08G18/1825 ,  C08G18/2036 ,  C08G18/246 ,  C08G18/26 ,  C08J9/144 ,  G01R33/5601 ,  C08G2101/00 ,  C08J2375/04

摘要： This invention relates to a method of directing a therapeutic agent to selected cells, wherein a complex is formed between a polysaccharide capable of interacting with a cell receptor and a therapeutic agent. The resulting complex is administered to a subject, and permitted to be internalized into the selected cells through a process known as receptor mediated endocytosis (RME). The polysaccharide may be, for example, arabinogalactan, gum arabic, mannan or hydrolysis products thereof; the therapeutic agent may be, for example, an antiviral agent, a nucleic acid, hormone, steroid, antibody, chemoprotective or radioprotective agent. The cell receptor may be for example, the asialoglycoprotein receptor or the mannose receptor.

摘要翻译： 本发明涉及将治疗剂引导至所选细胞的方法，其中在能够与细胞受体相互作用的多糖和治疗剂之间形成复合物。 将所得复合物施用于受试者，并允许通过称为受体介导的内吞作用（RME）的过程将其内化入所选择的细胞。 多糖可以是例如阿拉伯半乳聚糖，阿拉伯胶，甘露聚糖或其水解产物; 治疗剂可以是例如抗病毒剂，核酸，激素，类固醇，抗体，化学保护剂或放射防护剂。 细胞受体可以是例如脱唾液酸糖蛋白受体或甘露糖受体。

公开(公告)号：US5336506A

公开(公告)日：1994-08-09

申请号：US936873

申请日：1992-08-27

申请人： Lee Josephson ,  Ernest V. Groman ,  Chu Jung ,  Jerome M. Lewis

发明人： Lee Josephson ,  Ernest V. Groman ,  Chu Jung ,  Jerome M. Lewis

IPC分类号： A61K47/48 ,  A61K49/04 ,  A61K49/18 ,  C08G18/18 ,  C08G18/20 ,  C08G18/24 ,  C08G18/26 ,  C08J9/14 ,  G01R33/28 ,  A01K31/715

CPC分类号： C08J9/144 ,  A61K47/48076 ,  A61K47/4823 ,  A61K47/48861 ,  A61K49/0442 ,  B82Y5/00 ,  C08G18/1808 ,  C08G18/1816 ,  C08G18/1825 ,  C08G18/2036 ,  C08G18/246 ,  C08G18/26 ,  C08G2101/00 ,  C08J2375/04

摘要： The invention relates to a method for the targeting of a therapeutic agent to a specific population of cells, wherein a complex is formed between the therapeutic agent and a polysaccharide capable of interacting with a cell receptor, and wherein the resulting complex is internalized into the cell by receptor mediated endocytosis (RME). In one embodiment of the invention, a complex of a therapeutic agent containing iron and the polysaccharide arabinogalactan may be formed and used to deliver iron specifically to hepatocytes by RME.

摘要翻译： 本发明涉及一种用于将治疗剂靶向特定细胞群的方法，其中在治疗剂和能够与细胞受体相互作用的多糖之间形成复合物，并且其中所得的复合物被内化到细胞中 通过受体介导的内吞作用（RME）。 在本发明的一个实施方案中，可以形成含铁和多糖阿拉伯半乳聚糖的治疗剂的复合物，并用于通过RME将铁特异性地递送至肝细胞。

公开(公告)号：US5219554A

公开(公告)日：1993-06-15

申请号：US863360

申请日：1992-03-31

申请人： Ernest V. Groman ,  Lee Josephson ,  Jerome M. Lewis

发明人： Ernest V. Groman ,  Lee Josephson ,  Jerome M. Lewis

IPC分类号： A61K49/18 ,  C08G18/18 ,  C08G18/20 ,  C08G18/24 ,  C08G18/26 ,  C08J9/14 ,  G01R33/28

CPC分类号： G01R33/5601 ,  A61K49/18 ,  A61K49/1836 ,  A61K49/1863 ,  B82Y5/00 ,  C08G18/1808 ,  C08G18/1816 ,  C08G18/1825 ,  C08G18/2036 ,  C08G18/246 ,  C08G18/26 ,  C08J9/144 ,  C08G2101/00 ,  C08J2375/04 ,  Y10T436/24

摘要： This invention relates to materials exhibiting certain magnetic and biological properties which make them uniquely suitable for use as magnetic resonance imaging (MRI) agents to enhance MR images of animal organs and tissues. More particularly, the invention relates to the in vivo use of biologically degradable and metabolizable superparamagnetic metal oxides as MR contrast agents. Depending on their preparation, these metal oxides are in the form of superparamagnetic particle dispersoids or superparamagnetic fluids where the suspending medium is a physiologically-acceptable carrier, and may be uncoated or surrounded by a polymeric coating to which biological molecules can be attached. These materials are administered to animals, including humans, by a variety of routes and the metal oxides therein collect in specific target organs to be imaged; in the case of coated particles, the biological molecules can be chosen to target specific organs or tissues. The biodistribution of the metal oxides in target organs or tissues results in a more detailed image of such organs or tissues because the metal oxides, due to their superparamagnetic properties, exert profound effects on the hydrogen nuclei responsible for the MR image. In addition, the dispersoids and fluids are quite stable and, in the case of the fluids, can even be subjected to autoclaving without impairing their utility. Furthermore, the materials are biodegradable and, in the case of iron oxide compounds, can eventually be incorporated into the subject's hemoglobin, making them useful in treating anemia. Thus, the materials are well-suited for in vivo use.

摘要翻译： 本发明涉及具有某些磁性和生物学特性的材料，使得它们独特地适用于磁共振成像（MRI）试剂以增强动物器官和组织的MR图像。 更具体地，本发明涉及生物可降解和代谢的超顺磁性金属氧化物作为MR造影剂的体内应用。 取决于它们的制备，这些金属氧化物是超顺磁性颗粒分散体或超顺磁性流体的形式，其中悬浮介质是生理上可接受的载体，并且可以是未涂覆的或被可附着生物分子的聚合物涂层包围。 这些材料通过各种途径施用于包括人在内的动物，并且其中的金属氧化物收集在要成像的特定靶器官中; 在涂覆颗粒的情况下，可以选择生物分子来靶向特定的器官或组织。 金属氧化物在靶器官或组织中的生物分布导致这种器官或组织的更详细的图像，因为金属氧化物由于其超顺磁性质对负责MR图像的氢原子发挥深远的作用。 此外，分散体和流体是相当稳定的，并且在流体的情况下，甚至可以进行高压灭菌而不损害它们的效用。 此外，材料是可生物降解的，并且在氧化铁化合物的情况下，最终可以并入受试者的血红蛋白中，使其可用于治疗贫血。 因此，这些材料非常适合于体内使用。

公开(公告)号：US4827945A

公开(公告)日：1989-05-09

申请号：US67586

申请日：1987-06-26

申请人： Ernest V. Groman ,  Lee Josephson ,  Jerome M. Lewis

发明人： Ernest V. Groman ,  Lee Josephson ,  Jerome M. Lewis

IPC分类号： A61K33/26 ,  A61K31/695 ,  A61K31/715 ,  A61K33/00 ,  A61K38/00 ,  A61K39/00 ,  A61K39/395 ,  A61K49/00 ,  A61K49/18 ,  A61P7/06 ,  C01G49/00 ,  C08G18/18 ,  C08G18/20 ,  C08G18/24 ,  C08G18/26 ,  C08J9/14 ,  G01R33/28

CPC分类号： B82Y5/00 ,  A61K49/18 ,  A61K49/1806 ,  A61K49/1863 ,  A61K49/1869 ,  C08G18/1808 ,  C08G18/1816 ,  C08G18/1825 ,  C08G18/2036 ,  C08G18/246 ,  C08G18/26 ,  C08J9/144 ,  G01R33/5601 ,  C08G2101/00 ,  C08J2375/04

摘要： This invention relates to materials exhibiting certain magnetic and biological properties which make them uniquely suitable for use as magnetic resonance imaging (MRI) agents to enhance MR images of animal organs and tissues. More particularly, the invention relates to the in vivo use of biologically degradable and metabolizable superparamagnetic metal oxides as MR contrast agents. Depending on their preparation, these metal oxides are in the form of superparamagnetic particle dispersoids or superparamagnetic fluids where the suspending medium is a physiologically-acceptable carrier, and may be uncoated or surrounded by a polymeric coating to which biological molecules can be attached. These materials are administered to animals, including humans, by a variety of routes and the metal oxides therein collect in specific target organs to be imaged; in the case of coated particles, the biological molecules can be chosen to target specific organs or tissues. The biodistribution of the metal oxides in target organs or tissues results in a more detailed image of such organs or tissues because the metal oxides, due to their superparamagnetic properties, exert profound effects on the hydrogen nuclei responsible for the MR image. In addition, the dispersoids and fluids are quite stable and, in the case of the fluids, can even be subjected to autoclaving without impairing their utility. Furthermore, the materials are biodegradable and, in the case of iron oxide compounds, can eventually be incorporated into the subject's hemoglobin, making them useful in treating anemia. Thus, the materials are well-suited for in vivo use.

摘要翻译： 本发明涉及具有某些磁性和生物学特性的材料，使得它们独特地适用于磁共振成像（MRI）试剂以增强动物器官和组织的MR图像。 更具体地，本发明涉及生物可降解和代谢的超顺磁性金属氧化物作为MR造影剂的体内应用。 取决于它们的制备，这些金属氧化物是超顺磁性颗粒分散体或超顺磁性流体的形式，其中悬浮介质是生理上可接受的载体，并且可以是未涂覆的或被可附着生物分子的聚合物涂层包围。 这些材料通过各种途径施用于包括人在内的动物，并且其中的金属氧化物收集在要成像的特定靶器官中; 在涂覆颗粒的情况下，可以选择生物分子来靶向特定的器官或组织。 金属氧化物在靶器官或组织中的生物分布导致这种器官或组织的更详细的图像，因为金属氧化物由于其超顺磁性质对负责MR图像的氢原子发挥深远的作用。 此外，分散体和流体是相当稳定的，并且在流体的情况下，甚至可以进行高压灭菌而不损害它们的效用。 此外，材料是可生物降解的，并且在氧化铁化合物的情况下，最终可以并入受试者的血红蛋白中，使其可用于治疗贫血。 因此，这些材料非常适合于体内使用。

公开(公告)号：US5314679A

公开(公告)日：1994-05-24

申请号：US995111

申请日：1992-12-22

申请人： Jerome M. Lewis ,  Edward T. Menz ,  Francis E. Kenny ,  Ernest V. Groman ,  Lee Josephson

发明人： Jerome M. Lewis ,  Edward T. Menz ,  Francis E. Kenny ,  Ernest V. Groman ,  Lee Josephson

IPC分类号： A61K49/18 ,  C08G18/18 ,  C08G18/20 ,  C08G18/24 ,  C08G18/26 ,  C08J9/14 ,  G01R33/28 ,  A61B5/055 ,  A61K31/715 ,  A61K33/26 ,  A61K37/14

CPC分类号： G01R33/5601 ,  A61K49/18 ,  A61K49/1863 ,  B82Y5/00 ,  C08G18/1808 ,  C08G18/1816 ,  C08G18/1825 ,  C08G18/2036 ,  C08G18/246 ,  C08G18/26 ,  C08J9/144 ,  C08G2101/00 ,  C08J2375/04 ,  Y10S436/806 ,  Y10T436/24

摘要： The preparation and isolation of biodegradable superparamagnetic MR imaging contrast agents for the vascular compartment is described. These aggregates are comprised of individual biodegradable superparamagnetic metal oxide crystals which aggregates have an overall mean diameter less than about 4000 angstroms. The preferred vascular imaging contrast agent is comprised of aggregates of iron oxide crystals having an overall mean diameter less than about 500 angstroms. These contrast agents may be associated with a macromolecular species, which assist, among other things, in the preparation of these extremely small materials, and may be dispersed or dissolved in a physiologically acceptable medium. Preferred media also stabilize the materials against further aggregation even under harsh sterilization conditions. The autoclaved biodegradable superparamagnetic iron oxides of the invention are ideally suited for a pharmaceutical preparation and enjoy several advantages over prior intravascular imaging contrast media including low osmolality, low effective dose requirements, high relaxivities, long blood lifetimes, rapid biodegradability, and versatility with respect to a wide range of applicable MR data acquisition parameters.

摘要翻译： 描述了用于血管隔室的可生物降解的超顺磁性MR成像造影剂的制备和分离。 这些聚集体由单个可生物降解的超顺磁金属氧化物晶体组成，其聚集体具有小于约4000埃的总平均直径。 优选的血管成像造影剂由总平均直径小于约500埃的氧化铁晶体的聚集体组成。 这些造影剂可以与大分子物质相关联，其特别有助于制备这些极小物质，并且可以分散或溶解在生理上可接受的介质中。 优选的介质甚至在恶劣的灭菌条件下也稳定材料以防止进一步聚集。 本发明的高压消毒的可生物降解的超顺磁铁氧化物理想地适用于药物制剂，并且比先前的血管内成像造影剂具有若干优点，包括低渗透压浓度，低有效剂量要求，高松弛度，长血液寿命，快速生物降解性和相对于 广泛的适用MR数据采集参数。

公开(公告)号：US5069216A

公开(公告)日：1991-12-03

申请号：US409384

申请日：1989-09-19

申请人： Ernest V. Groman ,  Lee Josephson ,  Jerome M. Lewis

发明人： Ernest V. Groman ,  Lee Josephson ,  Jerome M. Lewis

IPC分类号： A61K49/18 ,  C08G18/18 ,  C08G18/20 ,  C08G18/24 ,  C08G18/26 ,  C08J9/14 ,  G01R33/28

CPC分类号： G01R33/5601 ,  A61K49/18 ,  A61K49/1863 ,  A61K49/1869 ,  B82Y5/00 ,  C08G18/1808 ,  C08G18/1816 ,  C08G18/1825 ,  C08G18/2036 ,  C08G18/246 ,  C08G18/26 ,  C08J9/144 ,  C08G2101/00 ,  C08J2375/04

摘要： This invention relates to materials exhibiting certain magnetic and biological properties which make them uniquely suitable for use as magnetic resonance imaging (MRI) agents to enhance MR images of animal organs and tissues. More particularly, the invention relates to the in vivo use of biologically degradable and metabolizable superparamagnetic metal oxides as MR contrast agents. Depending on their preparation, these metal oxides are in the form of superparamagnetic particle dispersoids or superparamagnetic fluids where the suspending medium is a physiologically-acceptable carrier, and may be uncoated or surrounded by a polymeric coating to which biological molecules can be attached. These materials are administered to animals, including humans, by a variety of routes and the metal oxides therein collect in specific target organs to be imaged; in the case of coated particles, the biological molecules can be chosen to target specific organs or tissues. The biodistribution of the metal oxides in target organs or tissues results in a more detailed image of such organs or tissues because the metal oxides, due to their superparamagnetic properties, exert profound effects on the hydrogen nuclei responsible for the MR image. In addition, the dispersoids and fluids are quite stable and, in the case of the fluids, can even be subjected to autoclaving without impairing their utility. Furthermore, the materials are biodegradable and, in the case of iron oxide compounds, can eventually be incorporated into the subject's hemoglobin, making them useful in treating anemia. Thus, the materials are well-suited for in vivo use.

摘要翻译： 本发明涉及具有某些磁性和生物学特性的材料，使得它们独特地适用于磁共振成像（MRI）试剂以增强动物器官和组织的MR图像。 更具体地，本发明涉及生物可降解和代谢的超顺磁性金属氧化物作为MR造影剂的体内应用。 取决于它们的制备，这些金属氧化物是超顺磁性颗粒分散体或超顺磁性流体的形式，其中悬浮介质是生理上可接受的载体，并且可以是未涂覆的或被可附着生物分子的聚合物涂层包围。 这些材料通过各种途径施用于包括人在内的动物，并且其中的金属氧化物收集在要成像的特定靶器官中; 在涂覆颗粒的情况下，可以选择生物分子来靶向特定的器官或组织。 金属氧化物在靶器官或组织中的生物分布导致这种器官或组织的更详细的图像，因为金属氧化物由于其超顺磁性质对负责MR图像的氢原子发挥深远的作用。 此外，分散体和流体是相当稳定的，并且在流体的情况下，甚至可以进行高压灭菌而不损害它们的效用。 此外，材料是可生物降解的，并且在氧化铁化合物的情况下，最终可以并入受试者的血红蛋白中，使其可用于治疗贫血。 因此，这些材料非常适合于体内使用。

公开(公告)号：US5055288A

公开(公告)日：1991-10-08

申请号：US233177

申请日：1988-08-16

申请人： Jerome M. Lewis ,  Edward T. Menz ,  Francis E. Kenny ,  Ernest V. Groman ,  Lee Josephson

发明人： Jerome M. Lewis ,  Edward T. Menz ,  Francis E. Kenny ,  Ernest V. Groman ,  Lee Josephson

IPC分类号： A61K49/18 ,  C08G18/18 ,  C08G18/20 ,  C08G18/24 ,  C08G18/26 ,  C08J9/14 ,  G01R33/28

CPC分类号： G01R33/5601 ,  A61K49/18 ,  A61K49/1863 ,  A61K49/1887 ,  B82Y5/00 ,  C08G18/1808 ,  C08G18/1816 ,  C08G18/1825 ,  C08G18/2036 ,  C08G18/246 ,  C08G18/26 ,  C08J9/144 ,  C08G2101/00 ,  C08J2375/04 ,  Y10T436/24

摘要： The preparation and isolation of biodegradable superparamagnetic MR imaging contrast agents for the vascular compartment is described. These aggregates are comprised of individual biodegradable superparamagnetic metal oxide crystals which aggregates have an overall mean diameter less than about 4000 angstroms. The preferred vascular imaging contrast agent is comprised of aggregates of iron oxide crystals having an overall mean diameter less than about 500 angstroms. These contrast agents may be associated with a macromolecular species, which assist, among other things, in the preparation of these extremely small materials, and may be dispersed or dissolved in a physiologically acceptable medium. Preferred media also stabilize the materials against further aggregation even under harsh sterilization conditions. The autoclaved biodegradable superparamagnetic iron oxides of the invention are ideally suited for a pharmaceutical preparation and enjoy several advantages over prior intravascular imaging contrast media including low osmolality, low effective dose requirements, high relaxivities, long blood lifetimes, rapid biodegradability, and versatility with respect to a wide range of applicable MR data acquisition parameters.

摘要翻译： 描述了用于血管隔室的可生物降解的超顺磁性MR成像造影剂的制备和分离。 这些聚集体由单个可生物降解的超顺磁金属氧化物晶体组成，其聚集体具有小于约4000埃的总平均直径。 优选的血管成像造影剂由总平均直径小于约500埃的氧化铁晶体的聚集体组成。 这些造影剂可以与大分子物质相关联，其特别有助于制备这些极小物质，并且可以分散或溶解在生理上可接受的介质中。 优选的介质甚至在恶劣的灭菌条件下也稳定材料以防止进一步聚集。 本发明的高压消毒的可生物降解的超顺磁铁氧化物理想地适用于药物制剂，并且比先前的血管内成像造影剂具有若干优点，包括低渗透压浓度，低有效剂量要求，高松弛度，长血液寿命，快速生物降解性以及相对于 广泛的适用MR数据采集参数。

公开(公告)号：US4951675A

公开(公告)日：1990-08-28

申请号：US244432

申请日：1988-09-14

申请人： Ernest V. Groman ,  Lee Josephson ,  Jerome M. Lewis

发明人： Ernest V. Groman ,  Lee Josephson ,  Jerome M. Lewis

IPC分类号： A61K49/18 ,  C08G18/18 ,  C08G18/20 ,  C08G18/24 ,  C08G18/26 ,  C08J9/14 ,  G01R33/28

CPC分类号： B82Y5/00 ,  A61K49/18 ,  A61K49/1863 ,  C08G18/1808 ,  C08G18/1816 ,  C08G18/1825 ,  C08G18/2036 ,  C08G18/246 ,  C08G18/26 ,  C08J9/144 ,  G01R33/5601 ,  C08G2101/00 ,  C08J2375/04 ,  Y10T436/24

摘要： This invention relates to materials exhibiting certain magnetic and biological properties which make them uniquely suitable for use as magnetic resonance imaging (MRI) agents to enhance MR images of animal organs and tissues. More particularly, the invention relates to the in vivo use of biologically degradable and metabolizable superparamagnetic metal oxides as MR contrast agents. Depending on their preparation, these metal oxides are in the form of superparamagnetic particle dispersoids or superparamagnetic fluids where the suspending medium is a physiologically-acceptable carrier, and may be uncoated or surrounded by a polymeric coating to which biological molecules can be attached. These materials are administered to animals, including humans, by a variety of routes and the metal oxides therein collect in specific target organs to be imaged; in the case of coated particles, the biological molecules can be chosen to target specific organs or tissues. The biodistribution of the metal oxides in target organs or tissues results in a more detailed image of such organs or tissues because the metal oxides, due to their superparamagnetic properties, exert profound effects on the hydrogen nuclei responsible for the MR image. In addition, the dispersoids and fluids are quite stable and, in the case of the fluids, can even be subjected to autoclaving without impairing their utility. Furthermore, the materials are biodegradable and, in the case of iron oxide compounds, can eventually be incorporated into the subject's hemoglobin, making them useful in treating anemia. Thus, the materials are well-suited for in vivo use.

摘要翻译： 本发明涉及具有某些磁性和生物学特性的材料，使得它们独特地适用于磁共振成像（MRI）试剂以增强动物器官和组织的MR图像。 更具体地，本发明涉及生物可降解和代谢的超顺磁性金属氧化物作为MR造影剂的体内应用。 取决于它们的制备，这些金属氧化物是超顺磁性颗粒分散体或超顺磁性流体的形式，其中悬浮介质是生理上可接受的载体，并且可以是未涂覆的或被可附着生物分子的聚合物涂层包围。 这些材料通过各种途径施用于包括人在内的动物，并且其中的金属氧化物收集在要成像的特定靶器官中; 在涂覆颗粒的情况下，可以选择生物分子来靶向特定的器官或组织。 金属氧化物在靶器官或组织中的生物分布导致这种器官或组织的更详细的图像，因为金属氧化物由于其超顺磁性质对负责MR图像的氢原子发挥深远的作用。 此外，分散体和流体是相当稳定的，并且在流体的情况下，甚至可以进行高压灭菌而不损害它们的效用。 此外，材料是可生物降解的，并且在氧化铁化合物的情况下，最终可以并入受试者的血红蛋白中，使其可用于治疗贫血。 因此，这些材料非常适合于体内使用。

公开(公告)号：US5478576A

公开(公告)日：1995-12-26

申请号：US900686

申请日：1992-06-17

申请人： Chu Jung ,  Philip Enriquez ,  Stephen Palmacci ,  Lee Josephson ,  Jerome M. Lewis

发明人： Chu Jung ,  Philip Enriquez ,  Stephen Palmacci ,  Lee Josephson ,  Jerome M. Lewis

IPC分类号： A61K47/48 ,  A61K49/18 ,  C08G18/18 ,  C08G18/20 ,  C08G18/24 ,  C08G18/26 ,  C08J9/14 ,  G01R33/28 ,  C07K17/00 ,  A61K38/14

CPC分类号： C08J9/144 ,  A61K47/4823 ,  A61K49/18 ,  A61K49/1809 ,  A61K49/1863 ,  B82Y5/00 ,  C08G18/1808 ,  C08G18/1816 ,  C08G18/1825 ,  C08G18/2036 ,  C08G18/246 ,  C08G18/26 ,  C08G2101/00 ,  C08J2375/04 ,  Y10S530/813

摘要： A substantially purified arabinogalactan, its degradative products and selected modifications thereof have been found to act as carriers for delivering therapeutic agent to cell receptors capable of receptor mediated endocytosis (RME). The arabinogalactan and its degrative products once derivatived are capable of forming a complex between the therapeutic agent and the polysaccharide such that the complex retains the ability to recognize and bind to the RME receptor.

摘要翻译： 已经发现基本上纯化的阿拉伯半乳聚糖，其降解产物及其选择的修饰被用作将治疗剂递送至能够受体介导的内吞作用（RME）的细胞受体的载体。 衍生的阿拉伯半乳聚糖及其衍生产物能够在治疗剂和多糖之间形成复合物，使得复合物保留识别和结合RME受体的能力。

公开(公告)号：US07871597B2

公开(公告)日：2011-01-18

申请号：US10410527

申请日：2003-04-09

申请人： Ernest V. Groman ,  Kenneth G. Paul ,  Timothy B. Frigo ,  Howard Bengele ,  Jerome M. Lewis

发明人： Ernest V. Groman ,  Kenneth G. Paul ,  Timothy B. Frigo ,  Howard Bengele ,  Jerome M. Lewis

IPC分类号： A61B5/055 ,  A01N43/04 ,  A61K31/715

CPC分类号： A61K49/126 ,  A61K9/14 ,  A61K31/721 ,  A61K33/26 ,  A61K47/36 ,  A61K47/6923 ,  A61K47/6929 ,  A61K49/186 ,  A61K49/1863 ,  B82Y5/00

摘要： Pharmacological compositions, and methods for administration, of the type employing an iron oxide complex with a polyol or polyether. The methods of administration may comprise parenteral administration of an effective dose of the complex formulated in a biocompatible liquid delivered at a rate of from about 1 mL/sec to less than 1 mL/min and wherein upon administration the complex provides minimal detectable free iron in a subject, and minimal incidence of anaphylaxis. The pharmacological compositions are of the type employing a polyol or polyether iron oxide complex, which, upon parenteral administration to a subject, are substantially immunosilent, provide minimal anaphylaxis and minimal free iron, and undergo minimal dissolution in vivo.

摘要翻译： 使用氧化铁配合物与多元醇或聚醚的类型的药物组合物和给药方法。 给药方法可以包括肠胃外给药配制在以约1mL / sec至小于1mL / min的速率递送的生物相容性液体中的复合物，并且其中在给药时，复合物提供了最小可检测的游离铁 一个主题和最小的过敏反应发生率。 药物组合物是使用多元醇或聚醚氧化铁络合物的类型，其在对受试者的肠胃外给药时基本上是免疫安全的，提供最小的过敏反应和最小的游离铁，并且在体内经历最小的溶解。