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    Polyol and Polyether Iron Oxide Complexes as Pharmacological and/or MRI Contrast Agents
    1.
    发明申请
    Polyol and Polyether Iron Oxide Complexes as Pharmacological and/or MRI Contrast Agents 有权
    多元醇和聚醚氧化铁配合物作为药理和/或MRI对比剂

    公开(公告)号：US20110144054A1

    公开(公告)日：2011-06-16

    申请号：US12963308

    申请日：2010-12-08

    申请人： Ernest V. Groman ,  Kenneth G. Paul ,  Timothy B. Frigo ,  Howard Bengele ,  Jerome M. Lewis

    发明人： Ernest V. Groman ,  Kenneth G. Paul ,  Timothy B. Frigo ,  Howard Bengele ,  Jerome M. Lewis

    IPC分类号： A61K31/721 ,  A61K31/715

    CPC分类号： A61K49/126 ,  A61K9/14 ,  A61K31/721 ,  A61K33/26 ,  A61K47/36 ,  A61K47/6923 ,  A61K47/6929 ,  A61K49/186 ,  A61K49/1863 ,  B82Y5/00

    摘要： Pharmacological compositions, and methods for administration, of the type employing an iron oxide complex with a polyol or polyether. The methods of administration may comprise parenteral administration of an effective dose of the complex formulated in a biocompatible liquid delivered at a rate of from about 1 mL/sec to less than 1 mL/min and wherein upon administration the complex provides minimal detectable free iron in a subject, and minimal incidence of anaphylaxis. The pharmacological compositions are of the type employing a polyol or polyether iron oxide complex, which, upon parenteral administration to a subject, are substantially immunosilent, provide minimal anaphylaxis and minimal free iron, and undergo minimal dissolution in vivo.

    摘要翻译： 使用氧化铁配合物与多元醇或聚醚的类型的药物组合物和给药方法。 给药方法可以包括肠胃外给药配制在以约1mL / sec至小于1mL / min的速率递送的生物相容性液体中的复合物，并且其中在给药时，复合物提供了最小可检测的游离铁 一个主题和最小的过敏反应发生率。 药物组合物是使用多元醇或聚醚氧化铁络合物的类型，其在对受试者的肠胃外给药时基本上是免疫安全的，提供最小的过敏反应和最小的游离铁，并且在体内经历最小的溶解。

    Hydrated biodegradable superparamagnetic metal oxides
    6.
    发明授权
    Hydrated biodegradable superparamagnetic metal oxides 失效
    水合生物降解超顺磁金属氧化物

    公开(公告)号：US5219554A

    公开(公告)日：1993-06-15

    申请号：US863360

    申请日：1992-03-31

    申请人： Ernest V. Groman ,  Lee Josephson ,  Jerome M. Lewis

    发明人： Ernest V. Groman ,  Lee Josephson ,  Jerome M. Lewis

    IPC分类号： A61K49/18 ,  C08G18/18 ,  C08G18/20 ,  C08G18/24 ,  C08G18/26 ,  C08J9/14 ,  G01R33/28

    CPC分类号： G01R33/5601 ,  A61K49/18 ,  A61K49/1836 ,  A61K49/1863 ,  B82Y5/00 ,  C08G18/1808 ,  C08G18/1816 ,  C08G18/1825 ,  C08G18/2036 ,  C08G18/246 ,  C08G18/26 ,  C08J9/144 ,  C08G2101/00 ,  C08J2375/04 ,  Y10T436/24

    摘要： This invention relates to materials exhibiting certain magnetic and biological properties which make them uniquely suitable for use as magnetic resonance imaging (MRI) agents to enhance MR images of animal organs and tissues. More particularly, the invention relates to the in vivo use of biologically degradable and metabolizable superparamagnetic metal oxides as MR contrast agents. Depending on their preparation, these metal oxides are in the form of superparamagnetic particle dispersoids or superparamagnetic fluids where the suspending medium is a physiologically-acceptable carrier, and may be uncoated or surrounded by a polymeric coating to which biological molecules can be attached. These materials are administered to animals, including humans, by a variety of routes and the metal oxides therein collect in specific target organs to be imaged; in the case of coated particles, the biological molecules can be chosen to target specific organs or tissues. The biodistribution of the metal oxides in target organs or tissues results in a more detailed image of such organs or tissues because the metal oxides, due to their superparamagnetic properties, exert profound effects on the hydrogen nuclei responsible for the MR image. In addition, the dispersoids and fluids are quite stable and, in the case of the fluids, can even be subjected to autoclaving without impairing their utility. Furthermore, the materials are biodegradable and, in the case of iron oxide compounds, can eventually be incorporated into the subject's hemoglobin, making them useful in treating anemia. Thus, the materials are well-suited for in vivo use.

    摘要翻译： 本发明涉及具有某些磁性和生物学特性的材料，使得它们独特地适用于磁共振成像（MRI）试剂以增强动物器官和组织的MR图像。 更具体地，本发明涉及生物可降解和代谢的超顺磁性金属氧化物作为MR造影剂的体内应用。 取决于它们的制备，这些金属氧化物是超顺磁性颗粒分散体或超顺磁性流体的形式，其中悬浮介质是生理上可接受的载体，并且可以是未涂覆的或被可附着生物分子的聚合物涂层包围。 这些材料通过各种途径施用于包括人在内的动物，并且其中的金属氧化物收集在要成像的特定靶器官中; 在涂覆颗粒的情况下，可以选择生物分子来靶向特定的器官或组织。 金属氧化物在靶器官或组织中的生物分布导致这种器官或组织的更详细的图像，因为金属氧化物由于其超顺磁性质对负责MR图像的氢原子发挥深远的作用。 此外，分散体和流体是相当稳定的，并且在流体的情况下，甚至可以进行高压灭菌而不损害它们的效用。 此外，材料是可生物降解的，并且在氧化铁化合物的情况下，最终可以并入受试者的血红蛋白中，使其可用于治疗贫血。 因此，这些材料非常适合于体内使用。

    Biologically degradable superparamagnetic materials for use in clinical applications
    7.
    发明授权
    Biologically degradable superparamagnetic materials for use in clinical applications 失效
    用于临床应用的生物可降解超顺磁材料

    公开(公告)号：US4827945A

    公开(公告)日：1989-05-09

    申请号：US67586

    申请日：1987-06-26

    申请人： Ernest V. Groman ,  Lee Josephson ,  Jerome M. Lewis

    发明人： Ernest V. Groman ,  Lee Josephson ,  Jerome M. Lewis

    IPC分类号： A61K33/26 ,  A61K31/695 ,  A61K31/715 ,  A61K33/00 ,  A61K38/00 ,  A61K39/00 ,  A61K39/395 ,  A61K49/00 ,  A61K49/18 ,  A61P7/06 ,  C01G49/00 ,  C08G18/18 ,  C08G18/20 ,  C08G18/24 ,  C08G18/26 ,  C08J9/14 ,  G01R33/28

    CPC分类号： B82Y5/00 ,  A61K49/18 ,  A61K49/1806 ,  A61K49/1863 ,  A61K49/1869 ,  C08G18/1808 ,  C08G18/1816 ,  C08G18/1825 ,  C08G18/2036 ,  C08G18/246 ,  C08G18/26 ,  C08J9/144 ,  G01R33/5601 ,  C08G2101/00 ,  C08J2375/04

    摘要： This invention relates to materials exhibiting certain magnetic and biological properties which make them uniquely suitable for use as magnetic resonance imaging (MRI) agents to enhance MR images of animal organs and tissues. More particularly, the invention relates to the in vivo use of biologically degradable and metabolizable superparamagnetic metal oxides as MR contrast agents. Depending on their preparation, these metal oxides are in the form of superparamagnetic particle dispersoids or superparamagnetic fluids where the suspending medium is a physiologically-acceptable carrier, and may be uncoated or surrounded by a polymeric coating to which biological molecules can be attached. These materials are administered to animals, including humans, by a variety of routes and the metal oxides therein collect in specific target organs to be imaged; in the case of coated particles, the biological molecules can be chosen to target specific organs or tissues. The biodistribution of the metal oxides in target organs or tissues results in a more detailed image of such organs or tissues because the metal oxides, due to their superparamagnetic properties, exert profound effects on the hydrogen nuclei responsible for the MR image. In addition, the dispersoids and fluids are quite stable and, in the case of the fluids, can even be subjected to autoclaving without impairing their utility. Furthermore, the materials are biodegradable and, in the case of iron oxide compounds, can eventually be incorporated into the subject's hemoglobin, making them useful in treating anemia. Thus, the materials are well-suited for in vivo use.

    摘要翻译： 本发明涉及具有某些磁性和生物学特性的材料，使得它们独特地适用于磁共振成像（MRI）试剂以增强动物器官和组织的MR图像。 更具体地，本发明涉及生物可降解和代谢的超顺磁性金属氧化物作为MR造影剂的体内应用。 取决于它们的制备，这些金属氧化物是超顺磁性颗粒分散体或超顺磁性流体的形式，其中悬浮介质是生理上可接受的载体，并且可以是未涂覆的或被可附着生物分子的聚合物涂层包围。 这些材料通过各种途径施用于包括人在内的动物，并且其中的金属氧化物收集在要成像的特定靶器官中; 在涂覆颗粒的情况下，可以选择生物分子来靶向特定的器官或组织。 金属氧化物在靶器官或组织中的生物分布导致这种器官或组织的更详细的图像，因为金属氧化物由于其超顺磁性质对负责MR图像的氢原子发挥深远的作用。 此外，分散体和流体是相当稳定的，并且在流体的情况下，甚至可以进行高压灭菌而不损害它们的效用。 此外，材料是可生物降解的，并且在氧化铁化合物的情况下，最终可以并入受试者的血红蛋白中，使其可用于治疗贫血。 因此，这些材料非常适合于体内使用。

    Hydrophobically modified proteins
    10.
    发明授权
    Hydrophobically modified proteins 失效
    疏水改性蛋白

    公开(公告)号：US5212235A

    公开(公告)日：1993-05-18

    申请号：US634369

    申请日：1990-12-27

    申请人： Eirik Nestaas ,  Kevin R. Hrebenar ,  Jerome M. Lewis ,  George M. Whitesides

    发明人： Eirik Nestaas ,  Kevin R. Hrebenar ,  Jerome M. Lewis ,  George M. Whitesides

    IPC分类号： C07K1/107 ,  C07K14/47

    CPC分类号： C07K1/1077 ,  C07K14/4732

    摘要： This invention relates to the production of oil-in-water emulsifiers and emulsion stabilizers. More particularly, this invention relates to methods for the production of novel hydrophobically modified proteins which may be used as emulsifiers or to stabilize emulsions.This invention also relates to products incorporating these hydrophobically modified protein emulsifiers and emulsion stabilizers. These compounds may be used in many applications such as paints, dyes and cosmetics.

    摘要翻译： 本发明涉及水包油乳化剂和乳液稳定剂的生产。 更具体地说，本发明涉及生产可用作乳化剂或稳定乳剂的新的疏水改性蛋白质的方法。 本发明还涉及结合这些疏水改性的蛋白质乳化剂和乳液稳定剂的产品。 这些化合物可用于许多应用中，例如油漆，染料和化妆品。