发明授权
US5374655A Methods for the synthesis of monofucosylated oligosaccharides
terminating in di-N-acetyllactosaminyl structures
失效
用于合成终止于二-N-乙酰乳糖胺基结构的单磷酸化寡糖的方法
- 专利标题： Methods for the synthesis of monofucosylated oligosaccharides terminating in di-N-acetyllactosaminyl structures
- 专利标题（中）： 用于合成终止于二-N-乙酰乳糖胺基结构的单磷酸化寡糖的方法
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申请号： US914172申请日： 1992-07-14
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公开(公告)号： US5374655A公开(公告)日： 1994-12-20
- 发明人: Mohammed Kashem , Andre P. Venot , Richard Smith
- 申请人： Mohammed Kashem , Andre P. Venot , Richard Smith
- 申请人地址： CAX Edmonton
- 专利权人： Alberta Research Council
- 当前专利权人： Alberta Research Council
- 当前专利权人地址： CAX Edmonton
- 优先权： WOXPCT/CA92/00251 19920610
- 主分类号： A61K31/70
- IPC分类号： A61K31/70 ; A61K39/00 ; C07H3/06 ; C07H15/04 ; C07H19/10 ; C07H19/20 ; C12P19/26 ; A01N37/12 ; A01N37/44 ; C12N7/06
摘要：
Disclosed are methods for the preparation of monofucosylated and sialylated derivatives of the compound .beta.Gal(1-4).beta.GlcNAc(1-3).beta.Gal(1-4).beta.GlcNAc-OR. In particular, the methods of this invention provide for a multi-step synthesis wherein selective monofucosylation is accomplished on the 3-hydroxy group on only one of the GlcNAc units found in the .beta.Gal(1-4) .beta.GlcNAc (1-3) .beta.Gal (1-4) .beta.GlcNAc-OR compound. In this step, monofucosylation is achieved by use of the .alpha.(1-3)fucosyltransferase.
公开/授权文献
- US4799156A Interactive market management system 公开/授权日：1989-01-17
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