发明授权
- 专利标题： PO438, a new calcium-regulated promoter
- 专利标题（中）： PO438，一种新的钙调节启动子
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申请号： US989363申请日： 1992-12-11
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公开(公告)号： US5385841A公开(公告)日： 1995-01-31
- 发明人: Jose D. Ortega , Jose A. Gil , Tomas V. Garcia , Juan F. Martin
- 申请人： Jose D. Ortega , Jose A. Gil , Tomas V. Garcia , Juan F. Martin
- 申请人地址： ESX Madrid
- 专利权人： Laboratorios Serono S.A.
- 当前专利权人： Laboratorios Serono S.A.
- 当前专利权人地址： ESX Madrid
- 优先权： ESX9102765 19911212
- 主分类号： C12N15/12
- IPC分类号： C12N15/12 ; C12N1/21 ; C12N9/02 ; C12N9/12 ; C12N15/09 ; C12N15/63 ; C12N15/76 ; C12P21/00 ; C12P21/02 ; C12R1/465 ; C12N15/00 ; C12N15/11
摘要：
There is disclosed a new calcium-regulated promoter to be used for increasing production of extracellular enzymes, or heterologous polypeptides, a recombinant vector that includes the DNA sequence of the promoter operatively linked to a DNA encoding said enzyme or polypeptide and a host organism transformed with the recombinant vector that includes the promoter operatively linked to the DNA encoding said enzyme or polypeptide. The present invention further relates to Streptomyces expression systems and methods for expressing foreign DNA sequences in Streptomyces and for secreting to the surrounding medium polypeptides and proteins coded for by those foreign DNA sequences.
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