发明授权
US5389539A Purification of heparinase I, II, and III from Flavobacterium heparinum
失效
从肝素肝素中纯化肝素酶I，II和III
- 专利标题： Purification of heparinase I, II, and III from Flavobacterium heparinum
- 专利标题（中）： 从肝素肝素中纯化肝素酶I，II和III
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申请号： US983367申请日： 1992-11-30
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公开(公告)号： US5389539A公开(公告)日： 1995-02-14
- 发明人: Ramnath Sasisekharan , Daniel L. Lohse , Charles L. Cooney , Robert J. Linhardt , Robert S. Langer
- 申请人： Ramnath Sasisekharan , Daniel L. Lohse , Charles L. Cooney , Robert J. Linhardt , Robert S. Langer
- 申请人地址： MA Cambridge IA Iowa City
- 专利权人： Massachusetts Institute of Technology,University of Iowa Research Foundation
- 当前专利权人： Massachusetts Institute of Technology,University of Iowa Research Foundation
- 当前专利权人地址： MA Cambridge IA Iowa City
- 主分类号： G01N33/573
- IPC分类号： G01N33/573 ; C07K16/40 ; C12N9/88 ; C12P19/26 ; C12P21/08 ; C12R1/20 ; C12R1/91 ; C12N9/00 ; C12N1/20 ; C12N9/52
摘要：
A purified heparinase I, II and III free of lyase activity and each having a molecular weight of 42,800 84,100, 70,800, respectively, are produced by culturing Flavobacterium heparinum. The kinetic properties of the heparinases have been determined as well as the conditions to optimize their activity and stability.
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