发明授权
- 专利标题: Dipeptide derivative and prophylactic and therapeutic agent for bone diseases containing the same
- 专利标题(中): 二肽衍生物及其含有骨病的预防和治疗剂
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申请号: US969453申请日: 1992-10-30
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公开(公告)号: US5395824A公开(公告)日: 1995-03-07
- 发明人: Naoki Higuchi , Masayuki Saitoh , Shinjiro Niwata , Yoshinobu Kiso , Yasuhiro Hayashi
- 申请人: Naoki Higuchi , Masayuki Saitoh , Shinjiro Niwata , Yoshinobu Kiso , Yasuhiro Hayashi
- 申请人地址: JPX Osaka
- 专利权人: Suntory Limited
- 当前专利权人: Suntory Limited
- 当前专利权人地址: JPX Osaka
- 优先权: JPX3-303351 19911119
- 主分类号: A61K31/335
- IPC分类号: A61K31/335 ; A61K31/357 ; A61K38/00 ; A61P3/02 ; A61P3/14 ; A61P19/10 ; A61P43/00 ; C07C237/12 ; C07C237/22 ; C07C251/38 ; C07C271/22 ; C07C281/10 ; C07C323/41 ; C07D235/14 ; C07D277/04 ; C07D317/28 ; C07D327/04 ; C07D339/06 ; C07D339/08 ; A61K37/02
摘要:
A prophylactic or therapeutic agent for malignant hypercalcemia, bone Paget's disease and osteoporosis is disclosed, which contains as an active ingredient a dipeptide derivative represented by formula:R.sup.1 NH--CH(R.sup.2)--CO--NH--CH(R.sup.3)--R.sup.4 (I)wherein R.sup.1 represents an aliphatic acyl group, a halogen-substituted aliphatic acyl group, or benzyloxycarbonyl group; R.sup.2 represents a lower alkyl group or an aralkyl group; R.sup.3 represents a lower alkyl group, an aralkyl group, or methylthioethyl group; R.sup.4 represents formyl group, an aliphatic acyl group, an aliphatic acyl group substituted with a halogen atom or a lower alkoxycarbonyl group, a di-lower alkoxymethyl group, a diacyloxymethyl group, a lower alkoxalyl group, a 1-hydroxy-2-lower alkoxycarbonylethyl group, a halogen-substituted 1-hydroxy-2-lower alkoxycarbonylethyl group, hydroxyiminomethyl group, ureidoiminomethyl group, benzimidazol-2-yl group, or a group: ##STR1## wherein A and B, which may be the same or different, each represents O, S, NH; and n represents 2 or 3; provided that R.sup.4 is not a formyl group when R.sup.3 is an n-butyl group.
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