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公开(公告)号：US20080124415A1
公开(公告)日：2008-05-29
申请号：US11630126
申请日：2005-06-29
申请人： Hiroaki Tanaka , Yoshinobu Kiso , Taeko Iino
发明人： Hiroaki Tanaka , Yoshinobu Kiso , Taeko Iino
CPC分类号： A61K31/352 , A23F3/163 , A23L33/105 , A61K31/353
摘要： The present invention provides a novel fat combustion accelerator which can promote lipid metabolism without changing the total consumption calories, characterized in that said fat combustion accelerator comprises proanthocyanidin as an active ingredient.
摘要翻译： 本发明提供了一种能够促进脂质代谢而不改变总消耗卡路里的新型脂肪燃烧促进剂，其特征在于所述脂肪燃烧促进剂包含原花色素作为活性成分。
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公开(公告)号：US20070099853A1
公开(公告)日：2007-05-03
申请号：US10561171
申请日：2004-05-14
申请人： Taeko Iino , Hiroaki Tanaka , Keisuke Sawaki , Natsue Koikawa , Yoshinobu Kiso
发明人： Taeko Iino , Hiroaki Tanaka , Keisuke Sawaki , Natsue Koikawa , Yoshinobu Kiso
IPC分类号： A61K31/7048 , A61K31/353
CPC分类号： A61K31/352 , A23L33/105
摘要： The present invention provides an agent for improving physiological motor functions which is characterized in containing proanthocyanidin as an effective ingredient. It is useful as an agent for preventing and improving the fatigue in which rise in lactic cid value upon physical exercise is suppressed whereby muscular fatigue is reduced and continuous exercise is made easy, and particularly as an agent for prevention and improvement of muscular fatigue, and as a health food for prevention and improvement of fatigue.
摘要翻译： 本发明提供一种改善生理运动功能的药剂，其特征在于含有原花色素作为有效成分。 作为用于预防和改善体育锻炼时乳酸值上升被抑制从而减轻肌肉疲劳并使连续运动变得容易的疲劳的作用剂，特别是作为预防和改善肌肉疲劳的药剂是有用的，以及 作为预防和改善疲劳的保健食品。
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3.发明授权Dipeptide derivative and prophylactic or therapeutic agent for bone diseases containing same as active ingredient 失效二肽衍生物和含有与活性成分相同的骨病的预防或治疗剂
公开(公告)号：US5399743A
公开(公告)日：1995-03-21
申请号：US121461
申请日：1993-09-16
IPC分类号： A61K31/16 , A61K31/27 , A61P3/00 , A61P3/14 , A61P19/10 , A61P43/00 , C07C237/22 , C07C271/22 , C07C261/00 , C07C233/00
CPC分类号： C07C271/22 , C07C237/22
摘要： A dipeptide derivative having the formula (I):R.sup.1 NH--CH(R.sup.2)--CO--NH--CH(R.sup.3)--COCH.sub.2 F (I)wherein, R.sup.1 is an aliphatic acyl group having 2 to 8 carbon atoms or a benzyloxycarbonyl group; andR.sup.2 and R.sup.3 are independently a hydrogen atom or a straight or branched alkyl group having 1 to 4 carbon atoms and a prophylactic or therapeutic agent containing the same as an active ingredient.
摘要翻译： 具有式（I）的二肽衍生物：R1NH-CH（R2）-CO-NH-CH（R3）-COCH2F（Ⅰ）其中，R1是碳原子数2〜8的脂肪族酰基或苄氧羰基; R2和R3独立地为氢原子或碳原子数为1〜4的直链或支链状的烷基以及含有该活性成分的预防或治疗剂。
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公开(公告)号：US20080260874A1
公开(公告)日：2008-10-23
申请号：US10594905
申请日：2005-03-31
摘要： The present invention provides a composition that can effectively improve peripheral blood flow to thereby ameliorate cold sensation, numbness, pains and other skin symptoms, as well as frostbites, chilblains and chaps and other skin disorders associated with disturbed peripheral blood flow. This composition has no side effects. Specifically, the peripheral blood flow-improving composition contains, as an active ingredient, a extract of a plant of the genus Lepidium of the family Cruciferae. More specifically, the composition contains as an active ingredient a extract of maca plant (Lepidium meyenii Walp). Food and beverage products, perfumes and cosmetics, and pharmaceutical products containing the peripheral blood flow-improving composition are also provided.
摘要翻译： 本发明提供一种组合物，其可以有效地改善外周血流量，从而改善冷感，麻木，疼痛和其它皮肤症状，以及与受干扰的外周血流相关的冻伤，冷冻和裂纹和其它皮肤病症。 该组合物没有副作用。 具体而言，外周血流量改善组合物含有十字花科植物的植物提取物作为活性成分。 更具体地，该组合物含有作为活性成分的马卡植物提取物（Lepidium meyenii Walp）。 还提供食品和饮料产品，香水和化妆品以及含有外周血液流动改善组合物的药物。
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公开(公告)号：US07001611B2
公开(公告)日：2006-02-21
申请号：US10030715
申请日：2001-05-15
申请人： Yoshinobu Kiso , Yoshiko Ono , Katsuya Nagai
发明人： Yoshinobu Kiso , Yoshiko Ono , Katsuya Nagai
IPC分类号： A61K47/00 , A61K31/405 , A61K31/12
CPC分类号： A61K31/122
摘要： The present invention provides a circadian rhythm normalizing composition containing astaxanthin and/or its ester as an active ingredient, and a composition having the action of enhancing the circadian rhythm normalizing action of melatonin by protecting melatonin. The composition can be in the form of a drug, a functional food, a food or a beverage.This composition has a circadian rhythm normalizing action, and has the action of preventing or alleviating sleep disorder and various diseases due to disturbance of the circadian rhythm.
摘要翻译： 本发明提供含有虾青素和/或其酯作为活性成分的昼夜节律标准化组合物，以及具有通过保护褪黑激素增强褪黑激素的昼夜节律正常化作用的作用的组合物。 组合物可以是药物，功能食品，食品或饮料的形式。
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公开(公告)号：US06852707B1
公开(公告)日：2005-02-08
申请号：US09857695
申请日：1999-12-09
申请人： Yoshinobu Kiso , Taeko Iino , Shinzo Kato
发明人： Yoshinobu Kiso , Taeko Iino , Shinzo Kato
IPC分类号： A61K31/00 , A61K31/70 , A61K31/7016 , A61K31/702 , A61P3/00 , A61P7/00 , A61P43/00 , C12N5/00
CPC分类号： A61K31/70 , A61K31/7016 , A61K31/702
摘要： By using xylobiose or xylooligosaccharide containing xylobiose as a main ingredient in place of lactulose, there is provided a blood ammonia lowering agent, a therapeutic agent of hyperammonemia or a therapeutic agent of hepatic encephalopathy that need be adminstered in smaller doses and which have no concern over side effects.Lactulose conventionally used as such drugs has to be administered in high doses and involves a safety problem when administered to patients with galactosemia or diabetes mellitus. The drug of the invention which contains xylobiose as a main ingredient solves these problems.
摘要翻译： 通过使用含有木二糖的木二糖或低聚木糖作为主要成分代替乳果糖，提供了血氨降解剂，高氨血症治疗剂或肝性脑病治疗剂，其需要以较小剂量施用且不关心 常规使用的乳糖苷必须以高剂量施用，并且当给予患有半乳糖血症或糖尿病的患者时涉及安全问题。 含有木二糖作为主要成分的本发明药物解决了这些问题。
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公开(公告)号：US06620424B1
公开(公告)日：2003-09-16
申请号：US09582425
申请日：2000-06-26
申请人： Yoshinobu Kiso , Aki Kusumoto , Eisuke Furuya
发明人： Yoshinobu Kiso , Aki Kusumoto , Eisuke Furuya
IPC分类号： A61K4700
CPC分类号： A61K31/194 , A23L33/10 , A23L33/20 , A23V2002/00 , A61K31/00 , A23V2250/1614 , A23V2250/16
摘要： A food or beverage containing an effective amount of a fructose-6-phosphate-2-kinase inhibitor which is safe and effective in vivo, such as itaconic acid, and a pharmaceutical composition containing the inhibitor as an active ingredient are disclosed. This food, beverage or pharmaceutical composition safely exerts an antiobesity, antidiabetic, and an antilipemic effect.
摘要翻译： 公开了含有有效量的体内安全有效的果糖-6-磷酸-2-激酶抑制剂如衣康酸的食品或饮料，以及含有抑制剂作为活性成分的药物组合物。 这种食品，饮料或药物组合物安全地发挥抗肥胖，抗糖尿病和抗血脂作用。
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8.发明授权
公开(公告)号：US5395824A
公开(公告)日：1995-03-07
申请号：US969453
申请日：1992-10-30
IPC分类号： A61K31/335 , A61K31/357 , A61K38/00 , A61P3/02 , A61P3/14 , A61P19/10 , A61P43/00 , C07C237/12 , C07C237/22 , C07C251/38 , C07C271/22 , C07C281/10 , C07C323/41 , C07D235/14 , C07D277/04 , C07D317/28 , C07D327/04 , C07D339/06 , C07D339/08 , A61K37/02
CPC分类号： C07D327/04 , C07C237/22 , C07C251/38 , C07C271/22 , C07C281/10 , C07C323/41 , C07D235/14 , C07D277/04 , C07D317/28 , C07D339/06 , C07D339/08
摘要： A prophylactic or therapeutic agent for malignant hypercalcemia, bone Paget's disease and osteoporosis is disclosed, which contains as an active ingredient a dipeptide derivative represented by formula:R.sup.1 NH--CH(R.sup.2)--CO--NH--CH(R.sup.3)--R.sup.4 (I)wherein R.sup.1 represents an aliphatic acyl group, a halogen-substituted aliphatic acyl group, or benzyloxycarbonyl group; R.sup.2 represents a lower alkyl group or an aralkyl group; R.sup.3 represents a lower alkyl group, an aralkyl group, or methylthioethyl group; R.sup.4 represents formyl group, an aliphatic acyl group, an aliphatic acyl group substituted with a halogen atom or a lower alkoxycarbonyl group, a di-lower alkoxymethyl group, a diacyloxymethyl group, a lower alkoxalyl group, a 1-hydroxy-2-lower alkoxycarbonylethyl group, a halogen-substituted 1-hydroxy-2-lower alkoxycarbonylethyl group, hydroxyiminomethyl group, ureidoiminomethyl group, benzimidazol-2-yl group, or a group: ##STR1## wherein A and B, which may be the same or different, each represents O, S, NH; and n represents 2 or 3; provided that R.sup.4 is not a formyl group when R.sup.3 is an n-butyl group.
摘要翻译： 公开了用于恶性高钙血症，骨佩吉特氏病和骨质疏松症的预防或治疗剂，其包含作为活性成分的由式：R1NH-CH（R2）-CO-NH-CH（R3）-R4（I）表示的二肽衍生物， 其中R1表示脂族酰基，卤素取代的脂族酰基或苄氧基羰基; R2表示低级烷基或芳烷基; R3表示低级烷基，芳烷基或甲硫基乙基; R4表示甲酰基，脂肪族酰基，被卤素原子或低级烷氧基羰基取代的脂族酰基，二低级烷氧基甲基，二酰氧基甲基，低级烷氧基，1-羟基-2-低级烷氧基羰基乙基 基团，卤素取代的1-羟基-2-低级烷氧基羰基乙基，羟基亚氨基甲基，脲基亚氨基甲基，苯并咪唑-2-基或基团：其中A和B各自可以相同或不同 表示O，S，NH; n表示2或3; 条件是当R 3为正丁基时，R 4不是甲酰基。
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公开(公告)号：US20080020067A1
公开(公告)日：2008-01-24
申请号：US10594900
申请日：2005-03-31
CPC分类号： A23G3/36 , A23C9/13 , A23C9/152 , A23G3/48 , A23L2/02 , A23L2/52 , A23L33/105 , A23V2002/00 , A61K8/97 , A61K36/31 , A61K2800/92 , A61Q19/007 , C12G3/04 , A23V2200/15 , A23V2200/044 , A23V2250/032 , A23V2250/606 , A23V2250/708 , A23V2250/21
摘要： The present invention provides an oral skin moisturizer that is readily available to those who are suffering from dry skin, has no side effects, and when orally ingested, enhances the moisture-retaining ability of the skin. The invention also provides food products or the like that contain the oral skin moisturizer. Specifically, the oral skin moisturizer contains, as an active ingredient, a extract of a plant of the genus Lepidium of the family Cruciferae. More specifically, the oral skin moisturizer contains as an active ingredient a extract of maca (Lepidium meyenii Walp). Food products, liquors, functional food products, and pharmaceutical products containing the oral skin moisturizer are also provided.
摘要翻译： 本发明提供一种口服皮肤保湿剂，其对于患有干性皮肤的患者容易获得，没有副作用，并且当口服摄取时，增强皮肤的保湿能力。 本发明还提供含有口腔保湿剂的食品等。 具体而言，口腔保湿剂含有十字花科植物的植物提取物作为活性成分。 更具体地，口腔保湿剂含有作为活性成分的马卡提取物（Lepidium meyenii Walp）。 还提供食品，酒，功能性食品和含有口腔保湿剂的药物。
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10.发明申请Composition having autonomic nerve modulating activity and method of use thereof 审中-公开具有自主神经调节活性的组合物及其使用方法公开(公告)号：US20060058376A1
公开(公告)日：2006-03-16
申请号：US10544490
申请日：2004-05-27
申请人： Toshio Moritani , Yoshinobu Kiso , Yoshiko Ono
发明人： Toshio Moritani , Yoshinobu Kiso , Yoshiko Ono
IPC分类号： A61K31/36
CPC分类号： A61K31/34
摘要： A composition having autonomic nerve function regulating action, comprising sesamin and/or episesamin as an active ingredient, is provided.
摘要翻译： 提供具有自主神经功能调节作用的组合物，其包含芝麻素和/或表芝麻素作为活性成分。
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