发明授权
- 专利标题: Microbial process for preparing mevinolin by a strain of aspergillus
- 专利标题(中): 用曲霉菌制备美维林的微生物过程
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申请号: US77364申请日: 1993-06-17
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公开(公告)号: US5403728A公开(公告)日: 1995-04-04
- 发明人: Antonia Jekkel , Eva Ilkoy , Istvan M. Szabo , Gabor Ambrus , Attila Andor , Ilona Varga , Imre Moravcsik , Istvan Szabo , Janos Erdei , Kalman Polya , Andras Kiss , Laszlo Cseke , Karoly Nagy , Mihaly Kaszas , Lajos Kiss , Istvan Magyi , Edit Halasz , Gyorgy Santha
- 申请人: Antonia Jekkel , Eva Ilkoy , Istvan M. Szabo , Gabor Ambrus , Attila Andor , Ilona Varga , Imre Moravcsik , Istvan Szabo , Janos Erdei , Kalman Polya , Andras Kiss , Laszlo Cseke , Karoly Nagy , Mihaly Kaszas , Lajos Kiss , Istvan Magyi , Edit Halasz , Gyorgy Santha
- 申请人地址: HUX Debrecen
- 专利权人: BIOGAL Gyogyszergyar RT
- 当前专利权人: BIOGAL Gyogyszergyar RT
- 当前专利权人地址: HUX Debrecen
- 优先权: HUXP9202020 19920617
- 主分类号: C07D309/30
- IPC分类号: C07D309/30 ; C12P7/62 ; C12P17/06 ; C12P7/00 ; C12P7/02
摘要:
The invention refers to a new microbial process for preparing .beta.,.delta.-dihydroxy-7-[1,2,6,7,8,8a-hexahydro-2.6-dimethyl-8-(2-methyl-butyryloxy)-naphthalen-1-yl]-heptanoic acid .delta.-lactone of formula (I) and .beta.,.delta.-dihydroxy-7-[1,2,6,7,8,8a-hexahydro-2.6-dimethyl-8-(2-methylbutyryloxy)-naphtalen-1-yl]-heptanoic acid of formula (II), ##STR1## by the aerobic fermentation of the submerged culture of an imperfect fungus strain biosynthesizing the above compounds, in a nutrient medium containing utilizable carbon and nitrogen sources as well as mineral salts, and by isolating the product of formula (I), which comprises cultivating a strain of the new Aspergillus obscurus fungus species producing the above compound(s) of formulas (I) and/or (II), in a temperature range of 25.degree. to 30.degree. C. and, if desired, separating the product(s) formed from the fermentation broth, then isolating it in the lactone form of formula (I) and, if desired, purifying the same.
公开/授权文献
- USD395169S Paint brush 公开/授权日:1998-06-16
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