发明授权
US5403840A Inclusion complexes of N-ethoxycarbonyl 1-3-morpholino-sydnonimine or
salts formed with cyclodextrin-derivatives, preparation thereof and
pharmaceutical compositions containing the same
失效
N-乙氧基羰基-3-吗啉代 - 脱水亚胺或与环糊精衍生物形成的盐的包合物，其制备方法和含有它们的药物组合物
- 专利标题： Inclusion complexes of N-ethoxycarbonyl 1-3-morpholino-sydnonimine or salts formed with cyclodextrin-derivatives, preparation thereof and pharmaceutical compositions containing the same
- 专利标题（中）： N-乙氧基羰基-3-吗啉代 - 脱水亚胺或与环糊精衍生物形成的盐的包合物，其制备方法和含有它们的药物组合物
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申请号： US807852申请日： 1992-01-02
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公开(公告)号： US5403840A公开(公告)日： 1995-04-04
- 发明人: Maria Vikmon , Jozsef Szejtli , Jozsef Gaal , Istvan Hermecz , Agnes Horvath , Katalin Marmarosi , Gabor Horvath , Iren Munkacsi
- 申请人： Maria Vikmon , Jozsef Szejtli , Jozsef Gaal , Istvan Hermecz , Agnes Horvath , Katalin Marmarosi , Gabor Horvath , Iren Munkacsi
- 申请人地址： HUX Budapest
- 专利权人： Chinoin Gyogyszer-Es Vegyeszeti Termekek Gyar Rt.
- 当前专利权人： Chinoin Gyogyszer-Es Vegyeszeti Termekek Gyar Rt.
- 当前专利权人地址： HUX Budapest
- 优先权： HUX1868/90 19900328; HUX1868/90/MODIFI 19900627
- 主分类号： C07D413/04
- IPC分类号： C07D413/04 ; A61K31/41 ; A61K31/42 ; A61K31/4245 ; A61K31/535 ; A61K31/5375 ; A61K31/5377 ; A61K47/40 ; A61K47/48 ; A61P9/08 ; A61P9/10 ; C07D265/28 ; C07D271/04 ; C07D271/10 ; C08B37/00 ; C08B37/06 ; C08B37/16 ; C06B37/16
摘要：
The invention relates to inclusion complexes of N-ethoxycarbonyl-3-morpholino-sydnonimine or its salts formed with a cyclodextrin derivatives, preparation thereof and pharmaceutical compositions containing the same.The inclusion complex of N-ethoxycarbonyl-3-morpholino-sydnonimine or its salt formed with cyclodextrin derivative is prepared bya) reacting the N-ethoxycarbonyl-3-morpholino-sydnonimine or its salt and the cyclodextrin derivative in a solvent medium, and if desired recovering the complex from the solution by dehydration, orb) high energy milling of the N-ethoxycarbonyl-3-morpholino-sydnonimine or its salt and the cyclodextrin derivative.