发明授权
US5411953A Oxazopinyl terminated alkylamino ethynyl alanine amino diol compounds
for treatment of hypertension
失效
用于治疗高血压的恶唑啉基封端的烷基氨基乙炔基丙氨酸氨基二醇化合物
- 专利标题: Oxazopinyl terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension
- 专利标题(中): 用于治疗高血压的恶唑啉基封端的烷基氨基乙炔基丙氨酸氨基二醇化合物
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申请号: US168561申请日: 1993-12-16
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公开(公告)号: US5411953A公开(公告)日: 1995-05-02
- 发明人: Gunnar J. Hanson , Robert E. Manning
- 申请人: Gunnar J. Hanson , Robert E. Manning
- 申请人地址: IL Chicago
- 专利权人: G. D. Searle & Co.
- 当前专利权人: G. D. Searle & Co.
- 当前专利权人地址: IL Chicago
- 主分类号: C07D295/12
- IPC分类号: C07D295/12 ; A61K31/395 ; A61K31/425 ; A61K31/535 ; A61K31/5375 ; A61K31/54 ; A61K31/55 ; A61P9/00 ; A61P9/12 ; A61P13/02 ; A61P15/00 ; A61P27/02 ; A61P27/06 ; A61P43/00 ; C07D265/06 ; C07D265/30 ; C07D265/32 ; C07D267/10 ; C07D277/04 ; C07D285/00 ; C07D295/13 ; C07D498/08
摘要:
Compounds characterized generally as oxazopinyl-terminated alkylamino ethynyl alanine amino diol derivatives are useful as renin inhibitors for the treatment of hypertension. Compounds of particular interest are those of Formula I ##STR1## wherein A is selected from CO and SO.sub.2 ; wherein X is selected from oxygen atom and methylene; wherein B is an oxazopinyl group; wherein R.sub.1 is selected from hydrido, methyl, ethyl, isopropyl and n-propyl; wherein R.sub.2 is phenylmethyl; wherein each of R.sub.3 and R.sub.5 is hydrido; wherein R.sub.4 is selected from--(CH.sub.2).sub.q --C.tbd.C-Vwherein V is selected from hydrido and methyl; wherein R.sub.6 is cyclohexylmethyl; wherein R.sub.7 is selected from isobutyl, cyclopropyl and cyclopropylmethyl; wherein q is a number selected from zero through three, inclusive; and wherein n is a number selected from zero through three, inclusive; or a pharmaceutically-acceptable salt thereof.
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