发明授权
- 专利标题: Preparation of alkyl 2-alkyl-4-fluoromethylthiazolecarboxylates
- 专利标题(中): 2-烷基-4-氟甲基噻唑羧酸烷基酯的制备
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申请号: US182701申请日: 1994-01-13
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公开(公告)号: US5442073A公开(公告)日: 1995-08-15
- 发明人: Karl Eicken , Klaus Ditrich , Thomas Mueller , Oliver Wagner
- 申请人: Karl Eicken , Klaus Ditrich , Thomas Mueller , Oliver Wagner
- 申请人地址: DEX Ludwigshafen
- 专利权人: BASF Aktiengesellscahft
- 当前专利权人: BASF Aktiengesellscahft
- 当前专利权人地址: DEX Ludwigshafen
- 优先权: DEX4301356.2 19930120
- 主分类号: C07D277/20
- IPC分类号: C07D277/20 ; C07D277/34 ; C07D277/56
摘要:
A process for preparing alkyl 2-alkyl-4-fluoromethylthiazolecarboxylates of the formula I ##STR1## where R.sup.1 is alkyl,R.sup.2 is difluoromethyl or trifluoromethyl andR.sup.3 is alkyl,by reacting thiocarboxamides of the formula II ##STR2## where R.sup.1 has the abovementioned meaning, with alkyl 2-chloro-4-fluoroacetoacetamides of the formula III ##STR3## where R.sup.2 and R.sup.3 have the abovementioned meanings, in an aprotic solvent at below 100.degree. C. and reacting with a dehydrating agent, in the presence of a base, at below 80.degree. C. is described.
公开/授权文献
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