公开(公告)号：US4257974A

公开(公告)日：1981-03-24

申请号：US85962

申请日：1979-10-18

申请人： Karl-Heinz Koenig ,  Heinz-Guenter Oeser ,  Karl-Heinz Feuerherd

发明人： Karl-Heinz Koenig ,  Heinz-Guenter Oeser ,  Karl-Heinz Feuerherd

IPC分类号： C07C265/02 ,  A01M20060101 ,  A61K20060101 ,  C07C20060101 ,  C07C67/00 ,  C07C241/00 ,  C07C263/16 ,  C07C265/04 ,  C09B20060101 ,  C07C119/042 ,  C07C119/045 ,  C07C119/048

CPC分类号： C07C263/16 ,  C07C2101/14

摘要： .alpha.,.beta.-Dihaloalkyl isocyanates and a process for the preparation of such compounds by reacting .alpha.,.beta.-unsaturated alkyl isocyanates with halogen in the presence of an organic solvent which is inert under the reaction conditions, at from -35.degree. to +90.degree. C. The .alpha.,.beta.-dihaloalkyl isocyanates thus obtainable correspond to the formula ##STR1## where R.sup.1, R.sup.2 and R.sup.3 are identical or different and each is hydrogen, a saturated aliphatic radical of 1 to 10 carbon atoms, a cycloaliphatic radical of 3 to 12 carbon atoms, an araliphatic radical of 7 to 11 carbon atoms or an aromatic radical of 6 to 10 carbon atoms, or R.sup.1 and R.sup.2 together with the carbon atom on which they are present as substituents are cycloalkyl of 3 to 7 ring members, and X is halogen. The compounds are valuable intermediates for the preparation of dyes, surface-coating intermediates, crop protection agents and drugs.

摘要翻译： α，β-二卤代烷基异氰酸酯和通过使α，β-不饱和烷基异氰酸酯与卤素在有效溶剂存在下反应来制备这些化合物的方法，所述有机溶剂在-35℃至+ 90℃的反应条件下是惰性的 C.由此获得的α，β-二卤代烷基异氰酸酯对应于式Ia，其中R 1，R 2和R 3相同或不同，各自为氢，1至10个碳原子的饱和脂族基团，3个脂环族基团 碳原子数为7〜11的芳脂族基团或6〜10个碳原子的芳香族基团，或者R1，R2与它们作为取代基存在的碳原子一起形成3〜7个环成员的环烷基， X为卤素。 这些化合物是制备染料，表面涂层中间体，作物保护剂和药物的有价值的中间体。

公开(公告)号：US07465774B1

公开(公告)日：2008-12-16

申请号：US08325219

申请日：1993-04-14

申请人： Christian Schade ,  Axel Sanner ,  Hans-Ulrich Wekel ,  Franz Frosch ,  Horst Westenfelder

发明人： Christian Schade ,  Axel Sanner ,  Hans-Ulrich Wekel ,  Franz Frosch ,  Horst Westenfelder

IPC分类号： C08F220/06

CPC分类号： A61K8/8164 ,  A61K47/32 ,  A61Q19/00 ,  C08F220/04 ,  C08F222/00

摘要： The use of copolymers obtainable by the radically initiated polymerization of A) 50 to 99.9 wt % of an olefinically unsaturated C3 to C5 monocarboxylic acid, an olefinically unsaturated C4 to C8 dicarboxylic acid or its anhydride, or a mixture of such carboxylic acids or carboxylic acid anhydrides with B) 0.1 to 50 wt % of one or more long-chained compounds with isolated multiple C—C bonds from the group (1) mono or polyunsaturated C8 to C30 monocarboxylic acids which may have additional hydroxyl groups and their alkaline metal and earth alkaline metal salts, alkyl esters, amides, sorbitane esters, glycerin esters and polyglycerin esters, (2) mono or polyunsaturated aliphatic Ca to C30 amines, (3) mono or polyunsaturated C8 to C30 alcohols and esters thereof with saturated Cl to C4 monocarboxylic acids, (4) to (C8 to C30 alkyl) vinyl ether which may incorporate up to 25 alkylene oxide units, and (5) final and medium-position Ci3 to C30 alkenes; C) 0 to 49.9 wt % of other copolymerizable monomers, and D) 0 to 10 wt % of one or more compounds with at least two olefinically unsaturated groups in the molecule as cross-linking agents, as thickening or dispersing agents, especially in cosmetic and pharmaceutical preparations.

摘要翻译： 通过自由基引发的A）50-99.9重量％的烯属不饱和C 3 -C 5单羧酸，烯属不饱和C 4 -C 8二羧酸或其酸酐，或这些羧酸或羧酸的混合物 酸酐与B）0.1至50重量％的一种或多种具有分离的多个CC键的长链化合物（1）可具有额外羟基的单或多不饱和C8至C30单羧酸及其碱金属和碱土金属 盐，烷基酯，酰胺，脱水山梨糖醇酯，甘油酯和聚甘油酯，（2）单或多不饱和脂肪族Ca至C30胺，（3）单或多不饱和C8至C30醇及其与饱和C1至C4单羧酸的酯（ 4）至（C8至C30烷基）乙烯基醚，其可以并入至多25个环氧烷单元，和（5）最终和中等位置的C 13至C 30烯烃; C）0〜49.9重量％的其它可共聚单体，D）0〜10重量％的一种或多种在分子中具有至少两个烯属不饱和基团的化合物作为交联剂，作为增稠剂或分散剂，特别是化妆品 和药物制剂。

公开(公告)号：US6096907A

公开(公告)日：2000-08-01

申请号：US395774

申请日：1999-09-14

申请人： Kai-Uwe Baldenius ,  Bernhard Bockstiegel ,  Hagen Jaedicke ,  Detlef Ruff ,  Carsten Siedenbiedel ,  Rainer Sturmer

发明人： Kai-Uwe Baldenius ,  Bernhard Bockstiegel ,  Hagen Jaedicke ,  Detlef Ruff ,  Carsten Siedenbiedel ,  Rainer Sturmer

IPC分类号： C07D311/70 ,  C07D311/72 ,  C07D311/76

CPC分类号： C07D311/72 ,  Y02P20/55

摘要： A process for preparing chromanol derivatives of the formula I ##STR1## where n is from 1 to 10,R.sup.1, R.sup.2,R.sup.3, R.sup.4 independently of one another are hydrogen or C.sub.1 -C.sub.4 alkyl,R.sup.5 is hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.6 -C.sub.10 aryl, C.sub.7 -C.sub.18 aralkyl, C.sub.7 -C.sub.18 alkylaryl, C.sub.1 -C.sub.22 acyl, or a group protecting the hydroxyl,by reduction of the corresponding 4-oxochromanol derivatives of the formula II ##STR2## comprises reacting the 4-oxochromanol derivatives of the formula II with metallic zinc in the presence of an acid or an acid mixture.Compounds of the formula I having C.sub.1 -C.sub.22 acyl as radical R.sup.5 can also be prepared by the above-described reduction of the compounds of the formula II with hydrogen as radical R.sup.5 and simultaneous or subsequent esterification.

摘要翻译： 一种制备式I的色原烷醇衍生物的方法，其中n为1至10，R 1，R 2，R 3，R 4彼此独立地为氢或C 1 -C 4烷基，R 5为氢，C 1 -C 4烷基，C 6 -C 10芳基 ，C 7 -C 18芳烷基，C 7 -C 18烷基芳基，C 1 -C 22酰基或保护羟基的基团，通过还原相应的式II的4-氧杂铬醇衍生物包括使式II的4-氧杂铬醇衍生物与金属锌 在酸或酸的混合物存在下进行。 具有作为自由基R5的C 1 -C 22酰基的式I化合物也可以通过上述将式II化合物以氢作为自由基R5还原并同时或随后进行酯化来制备。

公开(公告)号：US5442073A

公开(公告)日：1995-08-15

申请号：US182701

申请日：1994-01-13

申请人： Karl Eicken ,  Klaus Ditrich ,  Thomas Mueller ,  Oliver Wagner

发明人： Karl Eicken ,  Klaus Ditrich ,  Thomas Mueller ,  Oliver Wagner

IPC分类号： C07D277/20 ,  C07D277/34 ,  C07D277/56

CPC分类号： C07D277/56

摘要： A process for preparing alkyl 2-alkyl-4-fluoromethylthiazolecarboxylates of the formula I ##STR1## where R.sup.1 is alkyl,R.sup.2 is difluoromethyl or trifluoromethyl andR.sup.3 is alkyl,by reacting thiocarboxamides of the formula II ##STR2## where R.sup.1 has the abovementioned meaning, with alkyl 2-chloro-4-fluoroacetoacetamides of the formula III ##STR3## where R.sup.2 and R.sup.3 have the abovementioned meanings, in an aprotic solvent at below 100.degree. C. and reacting with a dehydrating agent, in the presence of a base, at below 80.degree. C. is described.

摘要翻译： 通过使式II的硫代甲酰胺反应，其中R 1具有式I的烷基，其中R 1是烷基，R 2是二氟甲基或三氟甲基，R 3是烷基，其中R 1是烷基， 具有式III III的2-氯-4-氟乙酰乙酸烷基酯，其中R 2和R 3具有上述含义，在低于100℃的非质子传递溶剂中，与脱水剂在脱水剂存在下反应， 描述了低于80℃的碱。