发明授权
US5474770A Biological support for cell cultures constituted by plasma proteins
coagulated by thrombin, its use in the preparation of keratocyte
cultures, their recovery and their transport for therapeutic purposes
失效
由凝血酶凝结的血浆蛋白构成的细胞培养物的生物支持，其用于制备角化细胞培养物，其回收及其用于治疗目的的运输
- 专利标题： Biological support for cell cultures constituted by plasma proteins coagulated by thrombin, its use in the preparation of keratocyte cultures, their recovery and their transport for therapeutic purposes
- 专利标题（中）： 由凝血酶凝结的血浆蛋白构成的细胞培养物的生物支持，其用于制备角化细胞培养物，其回收及其用于治疗目的的运输
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申请号： US850260申请日： 1992-03-12
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公开(公告)号： US5474770A公开(公告)日： 1995-12-12
- 发明人: Herve Broly , Vincent Ronfard
- 申请人： Herve Broly , Vincent Ronfard
- 申请人地址： FRX Lille
- 专利权人： Centre Regional de Transfusion Sanguine de Lille
- 当前专利权人： Centre Regional de Transfusion Sanguine de Lille
- 当前专利权人地址： FRX Lille
- 优先权： FRX8815950 19881206
- 主分类号： A61L27/60
- IPC分类号： A61L27/60 ; C12N5/00 ; C12N5/08 ; A01N1/02 ; A61F2/10 ; C07K14/745
摘要：
The present invention relates to a biological support for cell cultures formed by the coagulated mixture of a concentrate of plasma proteins and thrombin.The protein concentrate is obtained by precipitating fresh plasma with ethanol and contains balanced proportions of fibrinogen, Factor XIII and fibronectin. The thrombin concentration is adjusted to obtain the desired consistency of the support coagulated in the form of a film.The biological support is preferably used for preparing a culture of keratinocytes, recovering them in the form of a reconstituted tissue and transporting same. The reconstituted tissue is thus particularly suitable for use as a graft.
公开/授权文献
- US4681212A Accumulating conveyor 公开/授权日：1987-07-21
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