公开(公告)号：US20230132373A9

公开(公告)日：2023-04-27

申请号：US16404316

申请日：2019-05-06

申请人： THE GENERAL HOSPITAL CORPORATION

发明人： Falguni Asrani ,  William Farinelli ,  Ajay Shah ,  Vincent Liu ,  Richard R. Anderson

IPC分类号： A61B17/322 ,  A61F2/10

摘要： Methods and apparatus are provided for affecting an appearance of skin by harvesting small portions of tissue from a donor (first) site and applying them at a recipient (second) site. A plurality of micrografts can be formed from a piece of graft tissue and attached to a dressing material. The dressing material can then be expanded to increase a separation distance between the micrografts, and the dressing material having spaced-apart micrografts attached thereto can be applied to a prepared recipient site. An apparatus can be provided that expands the dressing material using a pressurized fluid. A further method can include providing a suspension of small portions of graft tissue in a solution. The solution can be injected into blisters formed at a recipient (second) site and the tissue portions allowed to attach and proliferate. A method and apparatus can also be provided for forming corresponding blisters at a donor site and at a recipient site. The raised (removed) portions of the blisters can be removed and attached to a dressing material, and the portions from the donor (first) site can be placed onto the exposed blister areas at the recipient site.

公开(公告)号：US11612410B2

公开(公告)日：2023-03-28

申请号：US15890046

申请日：2018-02-06

申请人： Edward Knowlton

发明人： Edward Knowlton

IPC分类号： A61B17/3211 ,  A61F2/10 ,  A61B17/322 ,  A61B90/00 ,  A61B17/3205 ,  A61B17/3209 ,  A61B17/3207 ,  A61B18/14 ,  A61B17/00 ,  A61B17/32 ,  A61B17/42 ,  A61B18/00 ,  A61M37/00 ,  A61B18/20 ,  A61N7/00 ,  A61B17/20 ,  A61B17/34 ,  A61B17/30

摘要： Systems, instruments, and methods for minimally invasive procedures including one or more of fractional resection, fractional lipectomy, fractional skin grafting, and/or fractional scar revision are described. Embodiments include instrumentation comprising a scalpet assembly coupled to a carrier, and the scalpet assembly includes a scalpet array. The scalpet array includes one or more scalpets configured for fractional resection, fractional lipectomy, fractional skin grafting, and/or fractional scar revision. The system includes a vacuum component coupled to the scalpet assembly and configured to evacuate tissue from the a site. The carrier is configured to control application of a rotational force and/or a vacuum force to the scalpet assembly.

公开(公告)号：US20230053327A9

公开(公告)日：2023-02-16

申请号：US17358463

申请日：2021-06-25

申请人： Washington University

发明人： Matthew R. MacEwan ,  Jingwei Xie ,  Zack Ray ,  Younan Xia

IPC分类号： A61F2/02 ,  B29C48/14 ,  D01D5/00 ,  D04H1/728 ,  D04H3/016 ,  D04H3/073 ,  A61F2/10 ,  A61L15/22 ,  A61L15/42 ,  A61F2/00 ,  A61L27/50 ,  B29C48/05 ,  A61L27/14 ,  C12M1/12

摘要： A multi-laminar electrospun nanofiber scaffold for use in repairing a defect in a tissue substrate is provided. The scaffold includes a first layer formed by a first plurality of electrospun polymeric fibers, and a second layer formed by a second plurality of electrospun polymeric fibers. The second layer is combined with the first layer. A first portion of the scaffold includes a higher density of fibers than a second portion of the scaffold, and the first portion has a higher tensile strength than the second portion. The scaffold is configured to degrade via hydrolysis after at least one of a predetermined time or an environmental condition. The scaffold is configured to be applied to the tissue substrate containing the defect, and is sufficiently flexible to facilitate application of the scaffold to uneven surfaces of the tissue substrate, and to enable movement of the scaffold by the tissue substrate.

公开(公告)号：US20220339324A1

公开(公告)日：2022-10-27

申请号：US17764523

申请日：2020-09-25

申请人： INDIAN INSTITUTUE OF TECHNOLOGY DELHI

发明人： Veena KOUL ,  Arani Varamuni PRASAD THANUSHA

IPC分类号： A61L27/60 ,  A61L27/56 ,  A61L27/22 ,  A61L27/20 ,  A61L27/54 ,  A61F2/10

摘要： The present invention relates to a novel acellular artificial skin substitute or scaffolds comprising biopolymer and bioactive components and the process of preparing said artificial skin substitute. The novel artificial foam-based skin substitute scaffold of the present invention addresses the problems in the prior art by providing a biocompatible, biodegradable, Non-immunogenic, non-irritant and a cost-effective scaffold.

公开(公告)号：US20220257282A1

公开(公告)日：2022-08-18

申请号：US17614858

申请日：2020-06-24

申请人： Doctor Biomed Co., Ltd.

发明人： Ki Won Kim

IPC分类号： A61B17/34 ,  A61B17/04 ,  A61F2/10

摘要： The present disclosure relates to a skin lifting thread inserting device and, more specifically, to a thread inserting device capable of enhancing a lifting effect by using a single cog thread connected to a plurality of needles. A thread inserting device for a skin lifting treatment according to one embodiment of the present disclosure comprises: first and second needles (10a, 10b); and first and second handles (20a, 20b), wherein the thread (100) extends from the opening (11a) formed at the distal end of the first needle (10a) to the opening (11b) formed at the distal end of the second needle (10b).

公开(公告)号：US20220226101A1

公开(公告)日：2022-07-21

申请号：US17433324

申请日：2020-02-28

申请人： Loria Products LLC

发明人： Victor LORIA

IPC分类号： A61F2/10

摘要： A hair implant suitable for subcutaneous implantation is provided having an anchor comprising an anchor body, and at least one collagen receiving structure selected from the group consisting of at least one tunnel disposed through the anchor body and an external surface feature of the anchor body. The anchor further comprises at least one hair strand projecting from a distal end of the anchor body, wherein the at least one collagen receiving structure is configured to support collagen ligature growth after subcutaneous implantation of the hair implant to anchor the anchor to a hair implant recipient, and the collagen receiving structure is free of hair. A fracture line in the anchor body allows the body to fragment, thereby releasing collagen ligatures and allowing the implant fragments to “release” and fall out of the skin. The at least one hair strand may comprise a primary hair element with emerging hair elements.

公开(公告)号：US11383007B2

公开(公告)日：2022-07-12

申请号：US16712535

申请日：2019-12-12

申请人： LifeCell Corporation

发明人： Alexander Ringo

IPC分类号： A61F2/10 ,  A61L27/60 ,  A61K35/36 ,  A61L27/50 ,  A61L27/36 ,  A61F2/00

摘要： The present disclosure relates to tissue matrix products. The products can includes tissue matrices that have holes or perforations located at certain positions to improve certain in vivo functions without substantial loss of strength or other important properties.

公开(公告)号：US20220170797A1

公开(公告)日：2022-06-02

申请号：US17109232

申请日：2020-12-02

申请人： POSTECH Research and Business Development Foundation ,  THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

发明人： Unyong JEONG ,  lnsang YOU ,  Zhenan BAO

IPC分类号： G01K1/26 ,  G01L1/22 ,  A61F2/10

摘要： A stretchable sensor, electronic skin, and a method of manufacturing the same are proposed. The stretchable sensor includes a first stretchable electrode including a first elastomer and a first conductor dispersed in the first elastomer, a stretchable active layer formed on the first stretchable electrode and including a third elastomer and an ion conductor dispersed in the third elastomer, and a second stretchable electrode formed on the stretchable active layer and including a second elastomer and a second conductor dispersed in the second elastomer. The stretchable sensor and the method of manufacturing the same are effectively capable of sensing a temperature without being affected by strain and recognizing strain without being affected by temperature.

公开(公告)号：US11278309B2

公开(公告)日：2022-03-22

申请号：US15890068

申请日：2018-02-06

申请人： SRGI HOLDINGS, LLC.

发明人： Edward Knowlton

IPC分类号： A61B17/3211 ,  A61B90/00 ,  A61B17/3205 ,  A61B17/3209 ,  A61B17/322 ,  A61B17/3207 ,  A61B18/14 ,  A61B17/00 ,  A61F2/10 ,  A61B17/32 ,  A61B17/42 ,  A61B18/00 ,  A61M37/00 ,  A61B18/20 ,  A61N7/00 ,  A61B17/20 ,  A61B17/34 ,  A61B17/30

摘要： Systems, instruments, and methods for minimally invasive procedures including one or more of fractional resection, fractional lipectomy, fractional skin grafting, and/or fractional scar revision are described. Embodiments include instrumentation comprising a scalpet assembly coupled to a carrier, and the scalpet assembly includes a scalpet array. The scalpet array includes one or more scalpets configured for fractional resection, fractional lipectomy, fractional skin grafting, and/or fractional scar revision. The system includes a vacuum component coupled to the scalpet assembly and configured to evacuate tissue from the a site. The carrier is configured to control application of a rotational force and/or a vacuum force to the scalpet assembly.

公开(公告)号：US11273235B2

公开(公告)日：2022-03-15

申请号：US15028391

申请日：2014-10-10

申请人： Fibralign Corporation

发明人： Catarina Hadamitzky ,  Tatiana Zaitseva ,  Michael V. Paukshto

IPC分类号： A61L27/24 ,  A61L27/54 ,  A61L27/58 ,  A61L27/60 ,  A61K38/18 ,  A61K35/26 ,  A61K35/16 ,  A61B18/20 ,  A61F2/10 ,  A61L27/36 ,  A61L27/50 ,  A61M5/142 ,  A61M25/01 ,  A61M27/00

摘要： Materials and methods are provided to direct the formation of new lymphatics and to reconnect the disrupted lymphatic network. These materials and methods enable to improve survival of lymph nodes and lymph node fragments and their integration into a lymphatic network, following lymph node and lymph node fragments transplantation. The treatment or prevention of lymphedema is also addressed. In certain embodiments, a bundle of fibers or fibrils presented in the composition is effective to stimulate and direct the formation of new lymphatic and blood vessels. The bundle of fibers or fibrils presented in the composition is effective to promote survival of the lymph node or lymph node fragments and integration of the lymph node or lymph node fragments into a lymphatic network in the mammalian subject, at the site of transfer or transplantation.