发明授权
US5547935A Muteins of human epidermal growth factor exhibiting enhanced binding at
low PH
失效
在低PH下表现出增强的结合的人表皮生长因子的突变蛋白
- 专利标题: Muteins of human epidermal growth factor exhibiting enhanced binding at low PH
- 专利标题(中): 在低PH下表现出增强的结合的人表皮生长因子的突变蛋白
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申请号: US284923申请日: 1994-08-02
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公开(公告)号: US5547935A公开(公告)日: 1996-08-20
- 发明人: Guy T. Mullenbach , Jeffrey M. Blaney , Steven Rosenberg
- 申请人: Guy T. Mullenbach , Jeffrey M. Blaney , Steven Rosenberg
- 申请人地址: CA Emeryville
- 专利权人: Chiron Corporation
- 当前专利权人: Chiron Corporation
- 当前专利权人地址: CA Emeryville
- 主分类号: A61K38/00
- IPC分类号: A61K38/00 ; C07K14/485 ; C12N15/18 ; A61K38/18
摘要:
EGF muteins in which the histidine at position 16 is replaced with a neutral or acidic amino acid exhibit activity at pHs lower than obtainable with wild type EGF.
公开/授权文献
- US6135446A Aligning device 公开/授权日:2000-10-24
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