Invention Grant
US5565560A O-Aryl,O-alkyl,O-alkenyl and O-alkynylmacrolides having
immunosuppressive activity
失效
具有免疫抑制活性的O-芳基，O-烷基，O-烯基和O-炔基羟基丙烯酰胺
- Patent Title: O-Aryl,O-alkyl,O-alkenyl and O-alkynylmacrolides having immunosuppressive activity
- Patent Title (中): 具有免疫抑制活性的O-芳基，O-烷基，O-烯基和O-炔基羟基丙烯酰胺
-
Application No.: US132072Application Date: 1993-10-04
-
Publication No.: US5565560APublication Date: 1996-10-15
- Inventor: Mark Goulet , Helen M. Organ , William H. Parsons , Peter J. Sinclair , Frederick Wong , Matthew J. Wyvratt
- Applicant: Mark Goulet , Helen M. Organ , William H. Parsons , Peter J. Sinclair , Frederick Wong , Matthew J. Wyvratt
- Applicant Address: NJ Rahway
- Assignee: Merck & Co., Inc.
- Current Assignee: Merck & Co., Inc.
- Current Assignee Address: NJ Rahway
- Main IPC: A61K31/41
- IPC: A61K31/41 ; A61K31/40 ; A61K31/435 ; A61K31/445 ; A61P17/00 ; A61P29/00 ; A61P31/12 ; A61P37/06 ; C07D498/18 ; C07D491/16
Abstract:
O-Aryl, O-alkyl, O-alkenyl and O-alkynyl-macrolides of the general structural Formula I: ##STR1## have been prepared from suitable precursors by alkylation and/or arylation at C-3" and/or C-4" of the cyclohexyl ring. These macrolide immunosuppressants are useful in a mammalian host for the treatment of autoimmune diseases, infectious diseases and/or the prevention of rejection of foreign organ transplants and/or related afflictions, diseases and illnesses.
Public/Granted literature
- US4312282A Positioning apparatus Public/Granted day:1982-01-26
Information query
