发明授权
- 专利标题： Methods of determining chemicals that modulate transcriptionally expression of genes associated with cardiovascular disease
- 专利标题（中）： 确定调节与心血管疾病相关基因转录表达的化学物质的方法
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申请号： US832905申请日： 1992-02-07
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公开(公告)号： US5580722A公开(公告)日： 1996-12-03
- 发明人: J. Gordon Foulkes , Franz E. Liechtfried , Christian Pieler , John R. Stephenson , Casey C. Case
- 申请人： J. Gordon Foulkes , Franz E. Liechtfried , Christian Pieler , John R. Stephenson , Casey C. Case
- 申请人地址： NY Uniondale
- 专利权人： Oncogene Science, Inc.
- 当前专利权人： Oncogene Science, Inc.
- 当前专利权人地址： NY Uniondale
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A61K48/00 ; C07K14/535 ; C07K14/61 ; C07K14/775 ; C12N9/02 ; C12N15/00 ; C12N15/65 ; C12N15/81 ; C12N15/85 ; C12Q1/68 ; C12P19/34
摘要：
The invention provided for a method of directly and specifically transcriptionally modulating the expression of a gene encoding a protein of interest associated with treatment of one or more symptoms of a cardiovascular disease such as atherosclerosis, restenosis or hypertension.Further provided is a method of determining whether a molecule not previously known to be a modulator of protein biosynthesis is capable of directly and specifically transcriptionally modulating the expression of a gene encoding a protein of interest associated with treatment of one or more symptoms of a cardiovascular disease.Lastly, the invention provides a method of directly and specifically transcriptionally modulating in a human being the expression of a gene encoding a protein of interest associated with treatment of one or more symptoms of a cardiovascular disease, thus ameliorating the disease.
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