发明授权
- 专利标题： Processes and intermediates for preparing macrocycles
- 专利标题（中）： 制备大环的方法和中间体
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申请号： US349413申请日： 1994-12-05
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公开(公告)号： US5621108A公开(公告)日： 1997-04-15
- 发明人: Amos B. Smith, III , Stephen M. Condon , Johnnie L. Leazer, Jr. , Robert E. Maleczka , John A. McCauley , James W. Leahy
- 申请人： Amos B. Smith, III , Stephen M. Condon , Johnnie L. Leazer, Jr. , Robert E. Maleczka , John A. McCauley , James W. Leahy
- 申请人地址： PA Philadelphia
- 专利权人： Trustees of the University of Pennsylvania
- 当前专利权人： Trustees of the University of Pennsylvania
- 当前专利权人地址： PA Philadelphia
- 主分类号： C07C35/17
- IPC分类号： C07C35/17 ; C07C49/11 ; C07C49/175 ; C07D303/14 ; C07D405/06 ; C07F7/18
摘要：
Novel processes for the preparation of lactam- and lactone-containing macrocyles are provided. In preferred embodiments, rapamycin and demethoxyrapamycin are prepared by a convergent synthesis regime. Intermediates useful in the synthetic processes are also provided.
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