发明授权
US5635488A Compounds having phosphorodithioate linkages of high chiral purity
失效
具有高手性纯度的二硫代磷酸酯键的化合物
- 专利标题: Compounds having phosphorodithioate linkages of high chiral purity
- 专利标题(中): 具有高手性纯度的二硫代磷酸酯键的化合物
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申请号: US470129申请日: 1995-06-06
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公开(公告)号: US5635488A公开(公告)日: 1997-06-03
- 发明人: Phillip D. Cook , Glenn Hoke
- 申请人: Phillip D. Cook , Glenn Hoke
- 申请人地址: CA Carlsbad
- 专利权人: Isis Pharmaceuticals, Inc.
- 当前专利权人: Isis Pharmaceuticals, Inc.
- 当前专利权人地址: CA Carlsbad
- 主分类号: C07H19/10
- IPC分类号: C07H19/10 ; C07H19/20 ; C07H21/00 ; C12N15/10 ; C12N15/113 ; C12P19/34 ; C12Q1/68 ; C12Q1/70 ; A61K31/70
摘要:
Sequence-specific phosphorothioate oligonucleotides comprising nucleoside units which are joined together by either substantially all Sp or substantially all Rp phosphorothioate intersugar linkages are provided. Such sequence-specific phosphorothioate oligonucleotides having substantially chirally pure intersugar linkages are prepared by enzymatic or chemical synthesis. Sequence-specific phosphorodithioate oligonucleotides are also provided. Such sequence-specific phosphorodithioate oligonucleotides are prepared by chemical synthesis. They are especially well suited as diagnostics, therapeutics and research reagents.
公开/授权文献
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