发明授权
- 专利标题： Method for oligonucleotide analog synthesis
- 专利标题（中）： 寡核苷酸类似物合成方法
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申请号： US234452申请日： 1994-04-28
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公开(公告)号： US5646269A公开(公告)日： 1997-07-08
- 发明人: Mark D. Matteucci , Jiancun Zhang
- 申请人： Mark D. Matteucci , Jiancun Zhang
- 申请人地址： CA Foster City
- 专利权人： Gilead Sciences, Inc.
- 当前专利权人： Gilead Sciences, Inc.
- 当前专利权人地址： CA Foster City
- 主分类号： C07H19/04
- IPC分类号： C07H19/04 ; C07H19/10 ; C07H19/20 ; C07H21/00 ; C07H19/06 ; C07H19/16
摘要：
The present invention is directed to improved methods to synthesize oligonucleotide analogs having an acetal linkage, such as a 3',5'-formacetal (3' --O--CH.sub.2 --O-- 5'), 3',5'-thioformacetal (3' --S--CH.sub.2 --O-- 5') or an analogous 2',5' linkage between adjacent nucleoside analog residues. Compositions comprising 5', 3' and 2' phosphinate nucleoside analogs useful in the methods are also provided.
公开/授权文献
- US4813237A Apparatus for making up feed water for a power station 公开/授权日：1989-03-21
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