发明授权
- 专利标题： Aryl substituted heterocycles
- 专利标题（中）： 芳基取代的杂环
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申请号： US228822申请日： 1994-04-18
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公开(公告)号： US5654299A公开(公告)日： 1997-08-05
- 发明人: Ashokkumar Bhikkappa Shenvi , Robert Toms Jacobs
- 申请人： Ashokkumar Bhikkappa Shenvi , Robert Toms Jacobs
- 申请人地址： GB2 London
- 专利权人： Zeneca Limited
- 当前专利权人： Zeneca Limited
- 当前专利权人地址： GB2 London
- 优先权： GBX9310713 19930524
- 主分类号： A61K31/445
- IPC分类号： A61K31/445 ; A61K31/4427 ; A61K31/443 ; A61K31/4433 ; A61K31/451 ; A61K31/452 ; A61K31/4523 ; A61K31/4525 ; A61K31/454 ; A61K31/4545 ; A61P11/00 ; A61P11/06 ; A61P11/08 ; A61P43/00 ; C07D20060101 ; C07D211/14 ; C07D211/20 ; C07D211/22 ; C07D211/24 ; C07D211/26 ; C07D211/32 ; C07D211/34 ; C07D211/42 ; C07D401/04 ; C07D405/04 ; C07D409/04 ; C07D413/04 ; C07D491/10 ; C07D491/107 ; A61K31/54 ; C07D211/06 ; C07D273/04
摘要：
The present invention concerns the novel use of aryl substituted heterocycles of formula I, set out below, which antagonize the pharmacological actions of one of ent endogenous neuropeptide tachykinins an the neurokinin 2 (NK2) receptor making them useful whenever such antagonism is desired, such as in the treatment of asthma and related conditions. The invention also provides pharmaceutical compositions containing the aryl substituted heterocycles for use in such treatment. Certain novel aryl substituted heterocycles of formula I and novel intermediates for their manufacture are also provided. ##STR1##
公开/授权文献
- US4878325A Two piece adjustable, reusable metal door frame 公开/授权日：1989-11-07