发明授权
- 专利标题： Peptide plasminogen activators
- 专利标题（中）： 肽纤溶酶原激活剂
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申请号： US381308申请日： 1995-01-31
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公开(公告)号： US5656269A公开(公告)日： 1997-08-12
- 发明人: Nancy L. Haigwood , Guy Mullenbach , Ernst-Guenter Afting , Eric Paul Paques
- 申请人： Nancy L. Haigwood , Guy Mullenbach , Ernst-Guenter Afting , Eric Paul Paques
- 申请人地址： CA Emeryville DEX Marburg-Lahn
- 专利权人： Chiron Corp.,Behringwerke AG
- 当前专利权人： Chiron Corp.,Behringwerke AG
- 当前专利权人地址： CA Emeryville DEX Marburg-Lahn
- 主分类号： C12N9/64
- IPC分类号： C12N9/64 ; A61K38/00 ; A61K38/46 ; A61K38/48 ; A61P7/02 ; C07H21/04 ; C07K14/745 ; C12N5/00 ; C12N5/10 ; C12N9/72 ; C12N15/00 ; C12N15/09 ; C12N15/10 ; C12N15/55 ; C12N15/58 ; C12P21/00 ; C12R1/91 ; A61K38/49 ; C12N15/63
摘要：
Novel polypeptide compositions based on the amino acid sequence of tissue plasminogen activator (tPA) are provided having improved properties over natural tissue plasminogen activator. Particularly, reduced fibrin stimulation of plasminogenolytic activity and/or enhanced affinity to fibrin surfaces are provided by modifying the C-terminus by deletions.
公开/授权文献
- US4954038A Two-tier storage rack for vehicles 公开/授权日：1990-09-04
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