发明授权
- 专利标题: Antimicrobial lactam-quinolones
- 专利标题(中): 抗菌内酰胺 - 喹诺酮类
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申请号: US692821申请日: 1991-04-26
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公开(公告)号: US5656623A公开(公告)日: 1997-08-12
- 发明人: Ronald Eugene White , Thomas Prosser Demuth, Jr.
- 申请人: Ronald Eugene White , Thomas Prosser Demuth, Jr.
- 申请人地址: OH Cincinnati
- 专利权人: The Procter & Gamble Company
- 当前专利权人: The Procter & Gamble Company
- 当前专利权人地址: OH Cincinnati
- 主分类号: C07D499/897
- IPC分类号: C07D499/897 ; A61K31/431 ; A61K31/47 ; A61K31/535 ; A61K31/545 ; A61K31/546 ; A61P31/04 ; A61P43/00 ; C07D215/56 ; C07D401/04 ; C07D401/12 ; C07D401/14 ; C07D409/12 ; C07D417/12 ; C07D417/14 ; C07D455/04 ; C07D463/00 ; C07D463/16 ; C07D471/04 ; C07D477/10 ; C07D477/14 ; C07D477/20 ; C07D487/04 ; C07D498/04 ; C07D498/06 ; C07D499/00 ; C07D499/04 ; C07D499/86 ; C07D499/87 ; C07D499/88 ; C07D501/00 ; C07D501/18 ; C07D501/20 ; C07D501/34 ; C07D503/00 ; C07D505/00 ; C07D513/04 ; C07D513/06 ; C07D513/16 ; C07D519/00 ; C07D519/06 ; C07D521/00 ; C07F9/6561
摘要:
Antimicrobial lactam-quinolone compounds comprising a lactam-containing moiety linked to a quinolone moiety, of the formula: ##STR1## wherein (1) A.sup.1, A.sup.2, A.sup.3, R.sup.1, R.sup.4 and R.sup.6 generally form any of a variety of quinolone, naphthyridine or related cyclic moieties known in the art to have antimicrobial activity; and(2) R.sup.1 or R.sup.3 contain a linking moiety, linking the quinolone moiety to a lactam-containing moiety having the formula: ##STR2## wherein (3) R.sup.10, R.sup.11, R.sup.12, R.sup.13, and R.sup.14, together with bonds "a" and "b", form any of a variety of lactam-containing moieties known in the art to have antimicrobial activity; and(4) the linking moiety includes (for example) carbamate, dithiocarbamate, urea, thiourea, isouronium, isothiouronium, guanidine, carbonate, trithiocarbonate, reversed carbamate, xanthate, reversed isouronium, reversed dithiocarbamate, reversed isothiouronium, amine, imine, ammonium, heteroarylium, ether, thioether, phosphono, phosphoramide, phosphate, sulfonamide, ester, thioester, amide, and hydrazide groups.
公开/授权文献
- US5716357A Spinal treatment and long bone fixation apparatus and method 公开/授权日:1998-02-10