发明授权
US5656634A N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl
coenzyme A: cholesterol acyl transferase (ACAT)
失效
N-芳基和N-杂芳基酰胺和脲衍生物作为酰基辅酶A的抑制剂：胆固醇酰基转移酶（ACAT）
- 专利标题： N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT)
- 专利标题（中）： N-芳基和N-杂芳基酰胺和脲衍生物作为酰基辅酶A的抑制剂：胆固醇酰基转移酶（ACAT）
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申请号： US251075申请日： 1994-05-31
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公开(公告)号： US5656634A公开(公告)日： 1997-08-12
- 发明人: George Chang , Ernest S. Hamanaka , Peter A. McCarthy , Thien V. Truong , Frederick J. Walker
- 申请人： George Chang , Ernest S. Hamanaka , Peter A. McCarthy , Thien V. Truong , Frederick J. Walker
- 申请人地址： NY New York
- 专利权人： Pfizer Inc.
- 当前专利权人： Pfizer Inc.
- 当前专利权人地址： NY New York
- 主分类号： C07C233/25
- IPC分类号： C07C233/25 ; C07C233/58 ; C07C233/59 ; C07C233/60 ; C07C235/24 ; C07C275/34 ; C07C317/44 ; C07C323/52 ; C07C323/60 ; C07D213/73 ; A61K31/44 ; C07D213/38 ; C07D239/42
摘要：
Compounds of the formula ##STR1## the pharmaceutically acceptable salts thereof, wherein Q and R.sup.1 are as defined below, and novel carboxylic acid and acid halide intermediates used in the synthesis of such compounds. The compounds of formula I are inhibitors of acyl coenzyme A: cholesterol acyltransferase (ACAT) and are useful as hypolipidemic and antiatherosclerosis agents.
公开/授权文献
- US4373254A Method of fabricating buried contacts 公开/授权日：1983-02-15
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