发明授权
- 专利标题： Melatonergic agents
- 专利标题（中）： 褪黑激素药
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申请号： US572838申请日： 1995-12-14
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公开(公告)号： US5661185A公开(公告)日： 1997-08-26
- 发明人: Katherine S. Takaki , George N. Karageorge , Daniel J. Keavy , Michael F. Parker , Brett T. Watson
- 申请人： Katherine S. Takaki , George N. Karageorge , Daniel J. Keavy , Michael F. Parker , Brett T. Watson
- 申请人地址： NJ Princeton
- 专利权人： Bristol-Myers Squibb Co.
- 当前专利权人： Bristol-Myers Squibb Co.
- 当前专利权人地址： NJ Princeton
- 主分类号： C07C233/18
- IPC分类号： C07C233/18 ; C07C233/20 ; C07C233/60 ; C07C235/08 ; C07C275/24 ; A61K31/17 ; C07C275/06
摘要：
New melatonergic agents are phenyl alkanyl or phenyl alkyl substituted carboxamides and ureas of Formula I: ##STR1## wherein: R.sub.1 =C.sub.1-3 alkyl, allyl, C.sub.3-6 cycloalkyl substituted C.sub.1-4 alkyl;R.sub.2 =hydrogen, halogen or C.sub.1-4 alkoxy;R.sub.3 =hydrogen or C.sub.1-4 alkyl;R.sub.4 =C.sub.1-4 alkyl, C.sub.1-4 alkyl substituted amino, carboxylic acid substitutedC.sub.1-4 alkyl or C.sub.3-6 cycloalkyl, C.sub.3-6 cycloalkyl, or straight or branched chainC.sub.2-4 alkenyl;A=a linear C.sub.2-4 alkanediyl or alkenediyl chain, provided that A not be --CH.sub.2 CH.sub.2 -- when X is a bond; andX=a covalent bond or oxygen.
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