发明授权
- 专利标题： Recombinant mutants for inducing specific immune responses
- 专利标题（中）： 用于诱导特异性免疫应答的重组突变体
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申请号： US479400申请日： 1995-06-07
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公开(公告)号： US5679784A公开(公告)日： 1997-10-21
- 发明人: Daniel Ladant , Claude Leclerc , Peter Sebo , Agnes Ullmann
- 申请人： Daniel Ladant , Claude Leclerc , Peter Sebo , Agnes Ullmann
- 申请人地址： FRX Paris
- 专利权人： Institut Pasteur
- 当前专利权人： Institut Pasteur
- 当前专利权人地址： FRX Paris
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; C07K14/005 ; C07K14/105 ; C07K14/11 ; C07K14/16 ; C07K14/495 ; C07K14/54 ; C07K14/55 ; C12N9/88 ; C12N15/31 ; C07H21/04
摘要：
A recombinant plasmid comprises the cyaC and the cyaA genes of Bordetella which directs the expression of Bordetella, adenylate cyclase in a transformed host cell. A recombinant DNA molecule can comprise the Bordetella cyaA gene containing at least one insertion of a heterologous DNA sequence at at least one permissive site. In addition, a recombinant Bordetella adenylate cyclase comprises a heterologous epitope at a permissive site. Methods of inducing a specific B cell, helper T cell, and CTL cell immune response are provided.
公开/授权文献
- US4987759A Machine for manufacturing helically-seaming tubing 公开/授权日：1991-01-29
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