Invention Grant
- Patent Title: Cartilage matrix protein and methods for use
- Patent Title (中): 软骨基质蛋白及其使用方法
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Application No.: US462128Application Date: 1995-06-05
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Publication No.: US5686059APublication Date: 1997-11-11
- Inventor: Paul F. Goetinck , Mehrdad Tondravi
- Applicant: Paul F. Goetinck , Mehrdad Tondravi
- Applicant Address: MA Boston
- Assignee: The General Hospital Corporation
- Current Assignee: The General Hospital Corporation
- Current Assignee Address: MA Boston
- Main IPC: C12N15/09
- IPC: C12N15/09 ; A61K38/00 ; A61K47/48 ; A61K49/00 ; A61K51/08 ; A61P43/00 ; C07K14/47 ; C07K14/78 ; C12N1/21 ; C12N15/12 ; C12P21/02 ; C12R1/19 ; A61K38/06 ; A61K38/17 ; C07K1/00
Abstract:
DNA constructs coding for a chimeric polypeptides containing fragments of cartilage matrix proteins that can bind collagen and their protein products are described. Also, the invention relates to purified chimeric polypeptides, and methods of their production and purification from transformed cells as well as their use as agents in therapeutics and clinical imaging. In addition, the invention disclosed a method for forming collagen fibrils using the chimeric polypeptide.
Public/Granted literature
- US4995222A Ampoule sealing apparatus Public/Granted day:1991-02-26
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