公开(公告)号：US5686059A

公开(公告)日：1997-11-11

申请号：US462128

申请日：1995-06-05

Applicant: Paul F. Goetinck ,  Mehrdad Tondravi

Inventor： Paul F. Goetinck ,  Mehrdad Tondravi

IPC: C12N15/09 ,  A61K38/00 ,  A61K47/48 ,  A61K49/00 ,  A61K51/08 ,  A61P43/00 ,  C07K14/47 ,  C07K14/78 ,  C12N1/21 ,  C12N15/12 ,  C12P21/02 ,  C12R1/19 ,  A61K38/06 ,  A61K38/17 ,  C07K1/00

CPC classification number: A61K47/48292 ,  A61K47/48307 ,  C07K14/78 ,  A61K38/00 ,  C07K2319/00

Abstract: DNA constructs coding for a chimeric polypeptides containing fragments of cartilage matrix proteins that can bind collagen and their protein products are described. Also, the invention relates to purified chimeric polypeptides, and methods of their production and purification from transformed cells as well as their use as agents in therapeutics and clinical imaging. In addition, the invention disclosed a method for forming collagen fibrils using the chimeric polypeptide.

Abstract translation: 描述了编码含有可结合胶原及其蛋白质产物的软骨基质蛋白片段的嵌合多肽的DNA构建体。 此外，本发明涉及纯化的嵌合多肽，以及它们从转化细胞产生和纯化的方法以及它们作为治疗剂和临床成像中的试剂的用途。 此外，本发明公开了使用嵌合多肽形成胶原纤维的方法。

公开(公告)号：US5741670A

公开(公告)日：1998-04-21

申请号：US463180

申请日：1995-06-05

Applicant: Paul F. Goetinck ,  Mehrdad Tondravi

Inventor： Paul F. Goetinck ,  Mehrdad Tondravi

IPC: C12N15/09 ,  A61K38/00 ,  A61K47/48 ,  A61K49/00 ,  A61K51/08 ,  A61P43/00 ,  C07K14/47 ,  C07K14/78 ,  C12N1/21 ,  C12N15/12 ,  C12P21/02 ,  C12R1/19 ,  C12P21/06 ,  C12N1/20 ,  C07N21/04

CPC classification number: A61K47/48292 ,  A61K47/48307 ,  C07K14/78 ,  A61K38/00 ,  C07K2319/00

Abstract: DNA constructs coding for a chimeric polypeptides containing fragments of cartilage matrix proteins that can bind collagen and their protein products are described. Also, the invention relates to purified chimeric polypeptides, and methods of their production and purification from transformed cells as well as their use as agents in therapeutics and clinical imaging. In addition, the invention disclosed a method for forming collagen fibrils using the chimetic polypeptide.

Abstract translation: 描述了编码含有可结合胶原及其蛋白质产物的软骨基质蛋白片段的嵌合多肽的DNA构建体。 此外，本发明涉及纯化的嵌合多肽，以及它们从转化细胞产生和纯化的方法以及它们作为治疗剂和临床成像中的试剂的用途。 此外，本发明公开了使用该模拟多肽形成胶原纤维的方法。