发明授权
- 专利标题： Intermediates for the preparation of demethylepipodophyllotoxin
- 专利标题（中）： 制备去甲表鬼臼毒素的中间体
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申请号： US441210申请日： 1995-05-15
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公开(公告)号： US5688925A公开(公告)日： 1997-11-18
- 发明人: Pietro Allevi , Mario Anastasia , Ettore Bigatti , Peter MacDonald
- 申请人： Pietro Allevi , Mario Anastasia , Ettore Bigatti , Peter MacDonald
- 申请人地址： ITX Milan
- 专利权人： Societa Italiana Cortico-Steroidi S.p.A.
- 当前专利权人： Societa Italiana Cortico-Steroidi S.p.A.
- 当前专利权人地址： ITX Milan
- 主分类号： A61K31/70
- IPC分类号： A61K31/70 ; A61K31/7042 ; A61K31/7048 ; A61K31/7135 ; A61P35/00 ; C07H1/00 ; C07H13/04 ; C07H17/04 ; C07H23/00
摘要：
Demethylepipodophyllotoxin-.beta.-glucosides are prepared by allowing demethylepipodophyllotoxin to react with a 2,3-di-O-ester of a 1-O-trialkylsilyl-4,6-O-alkylidene-.beta.-D-glucose derivative in the presence of a Lewis acid. The 4,6-O-alkylidene group can be alkylidene, arylalkylidene, or heteroarylalkylidene and the 2,3-ester can be lower alkanoyl or haloacetyl. In a typical embodiment, demethylepipodophyllotoxin is allowed to react with 4,6-O-ethylidene-2,3-di-O-acetyl-1-O-trimethylsilyl-.beta.-D-glucose in the presence of boron trifluoride etherate to yield etoposide 2",3"-diacetate.
公开/授权文献
- USD280077S Bottle 公开/授权日：1985-08-13
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