发明授权
US5691177A Recombinant retroviruses expressing a protein that converts a pro-drug
into a cytotoxic agent
失效
表达将前体药物转化成细胞毒性剂的蛋白质的重组逆转录病毒
- 专利标题： Recombinant retroviruses expressing a protein that converts a pro-drug into a cytotoxic agent
- 专利标题（中）： 表达将前体药物转化成细胞毒性剂的蛋白质的重组逆转录病毒
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申请号： US460996申请日： 1995-06-05
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公开(公告)号： US5691177A公开(公告)日： 1997-11-25
- 发明人: Harry E. Guber , Douglas J. Jolly , James G. Respess , Paul K. Laikind
- 申请人： Harry E. Guber , Douglas J. Jolly , James G. Respess , Paul K. Laikind
- 专利权人： Guber; Harry E.,Jolly; Douglas J.,Respess; James G.,Laikind; Paul K.
- 当前专利权人： Guber; Harry E.,Jolly; Douglas J.,Respess; James G.,Laikind; Paul K.
- 主分类号： A01K67/027
- IPC分类号： A01K67/027 ; A61K38/00 ; A61K38/19 ; A61K38/20 ; A61K38/21 ; A61K39/00 ; A61K39/21 ; A61K48/00 ; C07K14/155 ; C07K14/16 ; C07K14/73 ; C12N7/04 ; C12N9/12 ; C12N15/867 ; C12N5/08 ; C12N5/10
摘要：
Recombinant retroviruses carrying a vector construct capable of preventing, inhibiting, stabilizing or reversing infectious, cancerous or auto-immune diseases are disclosed. More specifically, the recombinant retroviruses of the present invention are useful for (a) stimulating a specific immune response to an antigen or a pathogenic antigen; (b) inhibiting a function of a pathogenic agent, such as a virus; and (c) inhibiting the interaction of an agent with a host cell receptor. In addition, eucaryotic cells infected with, and pharmaceutical compositions containing such a recombinant retrovirus are disclosed. Various methods for producing recombinant retroviruses having unique characteristics, and methods for producing transgenic packaging animals or insects are also disclosed.
公开/授权文献
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