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公开(公告)号：US20110217267A1
公开(公告)日：2011-09-08
申请号：US13072705
申请日：2011-03-26
IPC分类号： A61K35/76 , C12N9/78 , C12N15/85 , C12N15/86 , C12N15/867 , C12N5/10 , C12N7/01 , C07H21/00 , A61K48/00 , A61P35/00 , A61P19/02
CPC分类号： C12N7/00 , A61K2039/505 , C07K14/55 , C07K14/57 , C07K16/2818 , C07K2317/622 , C07K2319/00 , C12N9/1077 , C12N9/78 , C12N15/113 , C12N15/86 , C12N2310/141 , C12N2740/13043 , C12N2840/102 , C12N2840/203 , C12Y305/04001
摘要： This disclosure provides modified cytosine deaminases (CDs). The disclosure further relates to cells and vector expressing or comprising such modified CDs and methods of using such modified CDs in the treatment of disease and disorders.
摘要翻译： 本公开提供了修饰的胞嘧啶脱氨酶（CDs）。 本公开进一步涉及表达或包含此类修饰的CD的细胞和载体以及在治疗疾病和病症中使用这些修饰的CD的方法。
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公开(公告)号：US07977091B2
公开(公告)日：2011-07-12
申请号：US12538494
申请日：2009-08-10
申请人： Thomas W. Dubensky, Jr. , John M Polo , Carlos E Ibanez , Stephen M. W. Chang , Douglas J Jolly , David A Driver , Barbara A Belli
发明人： Thomas W. Dubensky, Jr. , John M Polo , Carlos E Ibanez , Stephen M. W. Chang , Douglas J Jolly , David A Driver , Barbara A Belli
CPC分类号： C12N15/113 , A61K38/00 , A61K48/00 , A61K2039/5256 , C07K14/005 , C07K14/47 , C07K14/705 , C07K14/755 , C07K14/82 , C12N9/2402 , C12N15/1131 , C12N15/86 , C12N2310/111 , C12N2310/122 , C12N2710/10322 , C12N2710/16722 , C12N2730/10122 , C12N2740/15022 , C12N2740/16222 , C12N2770/36122 , C12N2830/002 , C12N2830/42 , C12N2830/60 , C12N2840/20 , C12N2840/203 , C12N2840/206 , C12N2840/44 , C12N2840/85 , C12Y302/01045 , Y02A50/388 , Y02A50/396 , Y02A50/466 , Y10S977/773 , Y10S977/804 , Y10S977/808 , Y10S977/918 , Y10S977/92 , Y10S977/924
摘要： The present disclosure provides compositions and methods for utilizing recombinant alphavirus vectors. Also disclosed are compositions and methods for making and utilizing eukaryotic layered vector initiation systems.
摘要翻译： 本公开提供了利用重组甲病毒载体的组合物和方法。 还公开了用于制备和利用真核分层载体引发系统的组合物和方法。
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公开(公告)号：US07572628B2
公开(公告)日：2009-08-11
申请号：US10346880
申请日：2003-01-16
申请人： Thomas W. Dubensky, Jr. , John M. Polo , Carlos E. Ibanez , Stephen M. W. Chang , Douglas J. Jolly , David A. Driver , Barbara A. Belli
发明人： Thomas W. Dubensky, Jr. , John M. Polo , Carlos E. Ibanez , Stephen M. W. Chang , Douglas J. Jolly , David A. Driver , Barbara A. Belli
CPC分类号： C12N15/113 , A61K38/00 , A61K48/00 , A61K2039/5256 , C07K14/005 , C07K14/47 , C07K14/705 , C07K14/755 , C07K14/82 , C12N9/2402 , C12N15/1131 , C12N15/86 , C12N2310/111 , C12N2310/122 , C12N2710/10322 , C12N2710/16722 , C12N2730/10122 , C12N2740/15022 , C12N2740/16222 , C12N2770/36122 , C12N2830/002 , C12N2830/42 , C12N2830/60 , C12N2840/20 , C12N2840/203 , C12N2840/206 , C12N2840/44 , C12N2840/85 , C12Y302/01045 , Y02A50/388 , Y02A50/396 , Y02A50/466 , Y10S977/773 , Y10S977/804 , Y10S977/808 , Y10S977/918 , Y10S977/92 , Y10S977/924
摘要： The present invention provides compositions and methods for utilizing recombinant alphavirus vectors. Also disclosed are compositions and methods for making and utilizing eukaryotic layered vector initiation systems.
摘要翻译： 本发明提供了利用重组甲病毒载体的组合物和方法。 还公开了用于制备和利用真核分层载体引发系统的组合物和方法。
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公开(公告)号：US06241982B1
公开(公告)日：2001-06-05
申请号：US08468646
申请日：1995-06-06
IPC分类号： A61K4800
CPC分类号： A01K67/033 , A01K67/0275 , A01K2217/05 , A01K2217/30 , A01K2227/105 , A01K2267/03 , A61K35/13 , A61K38/2013 , A61K38/217 , A61K39/00 , A61K39/0011 , A61K48/00 , A61K2039/5256 , A61K2039/53 , A61K2039/57 , C07K14/005 , C07K14/70514 , C07K2319/00 , C12N7/00 , C12N9/1211 , C12N15/8509 , C12N15/86 , C12N2710/16622 , C12N2740/13022 , C12N2740/15022 , C12N2740/16023 , C12N2740/16043 , C12N2740/16052 , C12N2740/16322 , C12N2830/001 , C12N2830/60 , C12N2840/20
摘要： The present invention provides recombinant viral vectors carrying a vector construct which directs the expression of a gene product (e.g., HSVTK) that activates a compound with little or no cytotoxicity into a toxic product. Also provided are methods of destroying or inhibiting pathogenic agents in a warm blooded animal, comprising the step of administering to the animal a viral vector such as that described above, in order to inhibit or destroy the pathogenic agent.
摘要翻译： 本发明提供携带载体构建体的重组病毒载体，其引导将毒性产物激活具有很少或不具有细胞毒性的化合物的基因产物（例如HSVTK）的表达。 还提供了在温血动物中破坏或抑制病原体的方法，包括向动物施用如上所述的病毒载体以抑制或破坏病原体的步骤。
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5.发明授权Method for making reflection defective retroviral vectors for infecting human cells 失效复制用于感染人细胞的有缺陷的逆转录病毒载体的方法
公开(公告)号：US5856185A
公开(公告)日：1999-01-05
申请号：US472109
申请日：1995-06-07
申请人： Harry E. Gruber , Douglas J. Jolly , James G. Respess , Paul K. Laikind , Jack R. Barber , Daniel C. St. Louis , Sunil D. Chada , Stephen M. W. Chang , John F. Warner
发明人： Harry E. Gruber , Douglas J. Jolly , James G. Respess , Paul K. Laikind , Jack R. Barber , Daniel C. St. Louis , Sunil D. Chada , Stephen M. W. Chang , John F. Warner
IPC分类号： A01K67/027 , A01K67/033 , A61K38/00 , A61K38/20 , A61K38/21 , A61K39/00 , A61K39/21 , A61K48/00 , C07K14/15 , C07K14/155 , C07K14/16 , C07K14/73 , C12N5/10 , C12N7/04 , C12N9/12 , C12N15/85 , C12N15/867 , C07H21/04 , C12N15/48
CPC分类号： A01K67/033 , A61K38/2013 , A61K38/217 , A61K39/0011 , A61K39/12 , A61K39/21 , C07K14/005 , C07K14/70514 , C12N15/8509 , C12N15/86 , C12N7/00 , C12N9/1211 , A01K2217/05 , A01K2227/105 , A01K2267/01 , A01K2267/03 , A61K2039/5256 , A61K2039/53 , A61K2039/57 , A61K35/13 , A61K39/00 , A61K48/00 , C07K2319/00 , C12N2740/13023 , C12N2740/13032 , C12N2740/13043 , C12N2740/13052 , C12N2740/15022 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234
摘要： Recombinant retroviruses carrying a vector construct capable of preventing, inhibiting, stabilizing or reversing infectious, cancerous or auto-immune diseases are disclosed. More specifically, the recombinant retroviruses of the present invention are useful for (a) stimulating a specific immune response to an antigen or a pathogenic antigen; (b) inhibiting a function of a pathogenic agent, such as a virus; and (c) inhibiting the interaction of an agent with a host cell receptor. In addition, eucaryotic cells infected with, and pharmaceutical compositions containing such a recombinant retrovirus are disclosed. Various methods for producing recombinant retroviruses having unique characteristics, and methods for producing transgenic packaging animals or insects are also disclosed.
摘要翻译： 公开了携带能够预防，抑制，稳定或逆转感染性，癌性或自身免疫性疾病的载体构建体的重组逆转录病毒。 更具体地，本发明的重组逆转录病毒可用于（a）刺激对抗原或病原性抗原的特异性免疫应答; （b）抑制病原体如病毒的功能; 和（c）抑制药剂与宿主细胞受体的相互作用。 此外，公开了感染的真核细胞和含有这种重组逆转录病毒的药物组合物。 还公开了用于生产具有独特特征的重组逆转录病毒的各种方法，以及用于生产转基因包装动物或昆虫的方法。
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公开(公告)号：US5789245A
公开(公告)日：1998-08-04
申请号：US741881
申请日：1996-10-30
申请人： Thomas W. Dubensky, Jr. , John M. Polo , Carlos E. Ibanez , Stephen M. W. Chang , Douglas J. Jolly , David A. Driver
发明人： Thomas W. Dubensky, Jr. , John M. Polo , Carlos E. Ibanez , Stephen M. W. Chang , Douglas J. Jolly , David A. Driver
IPC分类号： A61K38/00 , A61K48/00 , C07K14/02 , C07K14/045 , C07K14/075 , C07K14/155 , C07K14/16 , C07K14/47 , C07K14/705 , C07K14/755 , C07K14/82 , C12N5/16 , C12N9/24 , C12N15/00 , C12N15/113 , C12N15/33 , C12N15/63 , C12N15/86 , C12N15/861 , C12P21/02 , C12N15/40 , C12N5/10
CPC分类号： C12N15/113 , C07K14/005 , C07K14/47 , C07K14/705 , C07K14/755 , C07K14/82 , C12N15/1131 , C12N15/86 , C12N9/2402 , C12Y302/01045 , A61K2039/5256 , A61K38/00 , A61K48/00 , C12N2310/111 , C12N2310/122 , C12N2710/10322 , C12N2710/16722 , C12N2730/10122 , C12N2740/15022 , C12N2740/16222 , C12N2770/36122 , C12N2830/002 , C12N2830/42 , C12N2830/60 , C12N2840/20 , C12N2840/203 , C12N2840/206 , C12N2840/44 , C12N2840/85 , Y10S977/773 , Y10S977/804 , Y10S977/808 , Y10S977/918 , Y10S977/92 , Y10S977/924
摘要： The present invention provides compositions and methods for utilizing recombinant alphavirus vectors. Also disclosed are compositions and methods for making and utilizing eukaryotic layered vector initiation systems.
摘要翻译： 本发明提供了利用重组甲病毒载体的组合物和方法。 还公开了用于制备和利用真核分层载体引发系统的组合物和方法。
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7.发明授权Recombinant retroviruses expressing a protein that converts a pro-drug into a cytotoxic agent 失效表达将前体药物转化成细胞毒性剂的蛋白质的重组逆转录病毒
公开(公告)号：US5691177A
公开(公告)日：1997-11-25
申请号：US460996
申请日：1995-06-05
IPC分类号： A01K67/027 , A61K38/00 , A61K38/19 , A61K38/20 , A61K38/21 , A61K39/00 , A61K39/21 , A61K48/00 , C07K14/155 , C07K14/16 , C07K14/73 , C12N7/04 , C12N9/12 , C12N15/867 , C12N5/08 , C12N5/10
CPC分类号： A01K67/0275 , A61K39/0011 , A61K39/12 , A61K39/21 , C07K14/005 , C07K14/70514 , C12N15/86 , C12N7/00 , C12N9/1211 , A01K2217/05 , A61K2039/5256 , A61K2039/53 , A61K2039/57 , A61K48/00 , C12N2740/13022 , C12N2740/13023 , C12N2740/13032 , C12N2740/13043 , C12N2740/13052 , C12N2740/15022 , C12N2740/16023 , C12N2740/16134 , C12N2740/16222
摘要： Recombinant retroviruses carrying a vector construct capable of preventing, inhibiting, stabilizing or reversing infectious, cancerous or auto-immune diseases are disclosed. More specifically, the recombinant retroviruses of the present invention are useful for (a) stimulating a specific immune response to an antigen or a pathogenic antigen; (b) inhibiting a function of a pathogenic agent, such as a virus; and (c) inhibiting the interaction of an agent with a host cell receptor. In addition, eucaryotic cells infected with, and pharmaceutical compositions containing such a recombinant retrovirus are disclosed. Various methods for producing recombinant retroviruses having unique characteristics, and methods for producing transgenic packaging animals or insects are also disclosed.
摘要翻译： 公开了携带能够预防，抑制，稳定或逆转感染性，癌性或自身免疫性疾病的载体构建体的重组逆转录病毒。 更具体地，本发明的重组逆转录病毒可用于（a）刺激对抗原或病原性抗原的特异性免疫应答; （b）抑制病原体如病毒的功能; 和（c）抑制药剂与宿主细胞受体的相互作用。 此外，公开了感染的真核细胞和含有这种重组逆转录病毒的药物组合物。 还公开了用于生产具有独特特征的重组逆转录病毒的各种方法，以及用于生产转基因包装动物或昆虫的方法。
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8.发明授权公开(公告)号：US09669049B2
公开(公告)日：2017-06-06
申请号：US13882487
申请日：2011-10-31
申请人： Harry E. Gruber , Douglas J. Jolly , Derek G. Ostertag , Ryan S. Burnett , Amy H. Lin , Tiffany Huang , Joan M. Robbins
发明人： Harry E. Gruber , Douglas J. Jolly , Derek G. Ostertag , Ryan S. Burnett , Amy H. Lin , Tiffany Huang , Joan M. Robbins
IPC分类号： A61K31/56 , A61K31/58 , A61K31/573 , A61K31/713 , A61K31/7088 , A61K39/21 , A61K39/395 , C12N15/867 , A61K35/768 , A61K9/127 , A61N5/10
CPC分类号： A61K31/7088 , A61K9/127 , A61K31/56 , A61K31/573 , A61K31/58 , A61K31/713 , A61K35/768 , A61K39/21 , A61K39/3955 , A61K39/39558 , A61N5/10 , C12N15/867 , C12N2740/13032 , A61K2300/00
摘要： This disclosure relates to replication competent viral vectors for treating cell proliferative disorders. The disclosure further relates to the use of such replication competent viral vectors for delivery and expression of a heterologous nucleic acid in normal and diseased tissues and methods and compositions that facilitate such delivery and expression to tissues in vivo and in vitro. The disclosure further relates to replication competent retroviral vectors for these uses and in conjunction with methods and compositions that facilitate in vivo therapeutics.
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公开(公告)号：US08829173B2
公开(公告)日：2014-09-09
申请号：US13072704
申请日：2011-03-26
IPC分类号： A61K48/00 , C07H21/00 , C12N15/867 , A61K35/76 , C12N15/63 , C12N9/78 , C12N15/86 , A61K38/22
CPC分类号： C12N7/00 , A61K31/513 , A61K38/2292 , A61K48/00 , C12N9/78 , C12N15/86 , C12N2740/13043 , C12N2760/16021 , C12N2760/16032 , C12N2760/16043
摘要： This disclosure provides recombinant replication competent retroviral vectors having increased stability. The disclosure further relates compositions and uses of such vectors in the treatment of disease and disorders.
摘要翻译： 本公开提供具有增加的稳定性的重组复制能力的逆转录病毒载体。 本公开进一步涉及这些载体在治疗疾病和病症中的组合物和用途。
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公开(公告)号：US07070994B2
公开(公告)日：2006-07-04
申请号：US10205179
申请日：2002-07-24
IPC分类号： C12N5/10 , C12N5/08 , C12N5/00 , C12N15/867 , C12N15/48
CPC分类号： C12N15/8509 , A01K67/033 , A01K2217/05 , A01K2267/01 , A61K35/13 , A61K38/2013 , A61K38/217 , A61K39/00 , A61K48/00 , A61K2039/5256 , A61K2039/53 , A61K2039/57 , C07K14/005 , C07K14/70514 , C07K2319/00 , C07K2319/32 , C12N7/00 , C12N9/1211 , C12N15/86 , C12N2740/13022 , C12N2740/13023 , C12N2740/13043 , C12N2740/13052 , C12N2740/15022 , C12N2740/16222
摘要： The invention described herein allows the production of recombinant retroviruses (retroviral vector particles) from producer cells which are safer and of higher titer than normal. In addition, methods are provided for making helper cells which, when a recombinant retrovirus genome is introduced to make a producer line, produce particles that are targeted toward particular cell types. Methods are also provided for making recombinant retrovirus systems adapted to infect a particular cell type, such as a tumor, by binding the retrovirus or recombinant retrovirus in the particular cell type. Methods are also provided for producing recombinant retroviruses which integrate in a specific small number of places in the host genome, and for producing recombinant retroviruses from transgenic animals.
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