发明授权
US5733911A Method for inducing death of neoplastic cells using piperazne derivatives
失效
使用哌嗪衍生物诱导肿瘤细胞死亡的方法
- 专利标题: Method for inducing death of neoplastic cells using piperazne derivatives
- 专利标题(中): 使用哌嗪衍生物诱导肿瘤细胞死亡的方法
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申请号: US592540申请日: 1996-01-26
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公开(公告)号: US5733911A公开(公告)日: 1998-03-31
- 发明人: Gabriel F. Eilon , John W. Jacobs
- 申请人: Gabriel F. Eilon , John W. Jacobs
- 申请人地址: JPX Tokyo CA Irvine JPX Tokyo
- 专利权人: Hitachi Chemical Co., Ltd.,Hitachi Chemical Research Center, Inc.,Nippon Chemiphar Co., Ltd.
- 当前专利权人: Hitachi Chemical Co., Ltd.,Hitachi Chemical Research Center, Inc.,Nippon Chemiphar Co., Ltd.
- 当前专利权人地址: JPX Tokyo CA Irvine JPX Tokyo
- 主分类号: C07D303/48
- IPC分类号: C07D303/48 ; A61K31/00 ; A61K31/443 ; A61K31/445 ; A61K31/4465 ; A61K31/452 ; A61K31/495 ; A61K31/496 ; A61K31/505 ; A61K31/506 ; A61P35/00 ; C07D405/12 ; C07D407/12 ; A61K31/50
摘要:
A method for inducing cell death in neoplastic cells, includes the step of administering a compound of formula I or a pharmaceutically acceptable salt thereof, as a primary chemotherapeutic agent or substantially contemporaneously with chemotherapy, to a patient having multidrug-resistant neoplastic cells, in an amount sufficient to induce cell death in the neoplastic cells: ##STR1## where R.sup.1 is hydroxyl, C1-4 alkoxyl, C1-4 alkylcarboxyloxymethoxyl, phenyl C1-2 alkylamino group, 2,5-pyrrolidinedione-1-alkoxyl (C1-4), or ##STR2## wherein X.sup.1 is a chemical bond or C1-2 alkylene, X.sup.2 is hydrogen or carboxyl forming a 5-membered ring with X.sup.1 when X.sup.2 is methylene, X.sup.3 is hydrogen or C1-2 alkyl, X.sup.4 is hydrogen or C1-2 alkyl, or X.sup.3 and X.sup.4 together form a 5-membered ring, in which at least one of X.sup.2, X.sup.3, and X.sup.4 is hydrogen, R.sup.2 is C3-4 alkyl, R.sup.3 is C1-4 alkyl, ##STR3## in which n is an integer of 0 to 3.
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