发明授权
- 专利标题: Difluoroprostacyclins
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申请号: US741905申请日: 1996-10-31
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公开(公告)号: US5747531A公开(公告)日: 1998-05-05
- 发明人: Yasushi Matsumura , Takashi Nakano , Mayumi Makino , Yoshitomi Morizawa
- 申请人: Yasushi Matsumura , Takashi Nakano , Mayumi Makino , Yoshitomi Morizawa
- 申请人地址: JPX Tokyo
- 专利权人: Asahi Glass Company Ltd.
- 当前专利权人: Asahi Glass Company Ltd.
- 当前专利权人地址: JPX Tokyo
- 优先权: JPX6-20450 19940217; JPX6-46853 19940317; JPX6-71097 19940408; JPX6-71989 19940411; JPX6-80641 19940419; JPX6-283857 19941117
- 主分类号: C07D307/93
- IPC分类号: C07D307/93 ; C07D307/935 ; C07D307/937 ; C07D407/12 ; C07D493/08 ; C07F7/18 ; A01N43/08
摘要:
A difluoroprostacyclin of the following formula (V), its lower alkanol ester or its pharmaceutically acceptable salt: ##STR1## wherein A is an ethylene group, a vinylene group or an ethynylene group, R is a substituted or unsubstituted C.sub.1-10 alkyl group, a substituted or unsubstituted C.sub.1-10 alkenyl group, a substituted or unsubstituted C.sub.1-10 alkynyl group, a substituted or unsubstituted C.sub.3-8 cycloalkyl group, a substituted or unsubstituted aralkyl group, or a substituted or unsubstituted aryloxy group, Q is a substituted or unsubstituted C.sub.1-10 alkyl group, a substituted or unsubstituted C.sub.1-10 alkenyl group, a substituted or unsubstituted C.sub.1-10 alkynyl group, a substituted or unsubstituted C.sub.3-8 cycloalkyl group, a substituted or unsubstituted aralkyl group, or a substituted or unsubstituted aryl group.